The value of Ca 125 in the evaluation of tuberculosis activity

Yılmaz, Adnan; Ece, Ferah; Bayramgürler, Birol; Akkaya, Esen; Baran, Reha

doi:10.1053/rmed.2001.1121

Cited by 51 publications

(43 citation statements)

References 18 publications

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“…A case-control study comparing patients with active tuberculosis with patients with cured tuberculosis confirmed a significant elevation of serum Ca 125 levels in patients with TB and a normalization of these levels during therapy [34]. Mean Ca 125 levels in patients with tuberculosis were significantly higher than that observed in patients with past tuberculosis, or healthy patients.…”

Section: Discussionmentioning

confidence: 98%

Ca-125: A Useful Marker to Distinguish Pulmonary Tuberculosis from Other Pulmonary Infections

Fortün¹,

Martín-Dávila²,

Méndez³

et al. 2009

TORMJ

130

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Introduction:Ca-125 is secreted by different celomic epitheliums. Serum levels may be increased in malignant diseases, like ovarian cancer but also in other medical conditions, such as pulmonary and extrapulmonary tuberculosis.Methods:From Jan-04 to Dec-06 a retrospective study analyzing Ca-125 levels in serum samples from patients with a diagnosis of pulmonary TB, was performed. These results were compared with those samples obtained from patients with non-TB pulmonary infections.Results:Eighty-nine patients were included in the study, thirty-five with pulmonary TB and 54 with other respiratory infections. In patients with TB, the mean Ca-125 value was 104.9 IU/ml (SD: ± 136.1). In the control group, mean value was 27.1 IU/ml (SD: ±19.7). The optimal cut-off for pulmonary tuberculosis was 32.5 IU/ml (sensitivity: 68.6%, specificity: 77.8%). Pulmonary TB was the only factor associated with a Ca-125 level >32.5. In 10 patients with TB, Ca-125 levels were available ≥ 2 months after starting TB therapy and a decrease during treatment was shown.Conclusions:Ca-125 values increase in patients with pulmonary TB and decline to normal values during treatment. Determination of Ca 125 may be usedin patients with a negative sputum AFB stain.

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Section: Discussionmentioning

confidence: 98%

Ca-125: A Useful Marker to Distinguish Pulmonary Tuberculosis from Other Pulmonary Infections

Fortün¹,

Martín-Dávila²,

Méndez³

et al. 2009

TORMJ

130

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“…[6][7][8] This lack of specificity has been widely investigated and CA125 has now been shown to be an effective marker for many diseases other than ovarian cancer. [9][10][11][12][13] At present, to the best of our knowledge, there are no guidelines produced by the Royal College of Pathologists or the Association of Clinical Biochemists to aid clinicians or laboratories in the most appropriate use of CA125.…”

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confidence: 99%

The role of CA125 in clinical practice

Moss

Hollingworth²,

Reynolds³

2005

J Clin Pathol

266

197

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Background: CA125 is a high molecular weight glycoprotein, which is expressed by a large proportion of epithelial ovarian cancers. The sensitivity and specificity of CA125 are poor and there are no guidelines produced by the Royal College of Pathologists or the Association of Clinical Biochemists to aid clinicians and laboratories in its most appropriate use. Aim: To identify the patient population having a CA125 measurement and to determine its contribution to individual patient management. Methods: A retrospective case note audit looking at patients who had a CA125 measurement performed between April 2000 and April 2002. Results: The study comprised 799 patients; 751 (94%) were female and 48 (6%) male; 221 (29%) females and 22 (46%) males had an abnormal result. CA125 was mainly used to investigate a wide range of signs and symptoms, and few tests were for follow up or screening of ovarian cancer. In female patients having a CA125 for suspicion of malignancy/ovarian cancer, only 39 (20%) of the abnormal results were caused by ovarian cancer. False positive results were largely caused by another malignancy (48 cases; 26%), benign ovarian disease (26 cases; 14%), and benign gynaecological conditions, particularly leiomyomas (18 cases; 9%). The specificity of CA125 for ovarian cancer increased with concentrations .1000 kU/ litre. Conclusions: These results confirm the high false positive rate and poor sensitivity and specificity associated with CA125. The substantial inappropriate usage of CA125 has led to results that are useless to the clinician, have cost implications, and add to patient anxiety and clinical uncertainty.

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“…Usually dry TB without ascites show endometrial involvement , adenexal masses, loculated fluid and adhesion. Patients improvement are evidenced by anti tubercular therapy evidenced by decrease in ascites, serum CA 125 level and resolution of abdominal distention and mass 22 .…”

Section: Discussionmentioning

confidence: 99%

Abdomino Pelvic Tuberculosis Versus Advanced Ovarian Malignancy : A Diagnostic Dilemma

Noor

Nahar

Bilkis

et al. 2015

Chatt Maa Shi Hosp Med Coll J

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Pelvic tuberculosis a common infectious cause of human death remains a global health problem, primarily in developing countries .Diagnosis of extra-pulmonary tuberculosis is challenging as it is rarely pinpointed by clinical symptoms, laboratory and radiological findings of low specificity. Pelvic tuberculosis should be considered in young women presented with pelvic mass, ascites and elevated serum CA 125. A series of fourteen cases between the 20 to 70 years are being reported having spectrum of clinical feature and creating diagnostic dilemma. The final diagnosis was made by histopathology after FNAC, laparoscopy or laparotomy are reviewed here. So the aim was formulation of high degree of suspicion aided by intensive investigation for timely diagnosis of genital tuberculosis, to see the response of antituberculer therapy and avoid unnecessary extended surgery.

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The value of Ca 125 in the evaluation of tuberculosis activity

Cited by 51 publications

References 18 publications

Ca-125: A Useful Marker to Distinguish Pulmonary Tuberculosis from Other Pulmonary Infections

Ca-125: A Useful Marker to Distinguish Pulmonary Tuberculosis from Other Pulmonary Infections

The role of CA125 in clinical practice

Abdomino Pelvic Tuberculosis Versus Advanced Ovarian Malignancy : A Diagnostic Dilemma

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