The Value of Magnetic Resonance Imaging in the Diagnosis of Suspected Penile Fracture with Atypical Clinical Findings

Fedel, Michael; Venz, Stephan; Andreessen, Rudiger; Sudhoff, Frank; Loening, Stefan A.

doi:10.1016/s0022-5347(01)66049-x

Cited by 97 publications

(20 citation statements)

References 11 publications

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“…Cavernosonography is invasive, involves injecting a dye into the cavernosa, and has been associated with side effects including allergic reactions and priapism [1]. Magnetic resonance imaging has been used recently with reasonable accuracy but is time consuming and not always available [6]. Ultrasound has been used increasingly, and there are some older case reports describing successful diagnosis in this setting [7,8].…”

Section: Discussionmentioning

confidence: 99%

Point-of-care ultrasound used to exclude penile fracture

2012

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This is a case report of a superficial penile hematoma that was difficult to distinguish clinically from a penile fracture. Such cases occur with relative frequency, and because definitive treatment is an urgent surgery, timely diagnosis is essential to avoid complications. Typical imaging modalities such as cavernosonography and magnetic resonance imaging can be invasive (cavernosonography) or time consuming (magnetic resonance imaging) and may not be readily available. Ultrasound has been used successfully in such cases, and, in this case, we used point-of-care ultrasound combined with a brief period of observation to exclude penile fracture.

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Section: Discussionmentioning

confidence: 99%

Point-of-care ultrasound used to exclude penile fracture

2012

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“…MRI and ICP are used to detect the change of penile tissue structure and erectile function in this study. VEGF promotes ECs to produce nitric oxide, which regulate the relaxation of cavernous smooth muscle [40]. Park et al.…”

Section: Discussionmentioning

confidence: 99%

The Therapeutic Role of VEGF-Expressing Muscle-Derived Stem Cells in Acute Penile Cavernosal Injury

Wei

et al. 2012

The Journal of Sexual Medicine

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Introduction Traumatic penile injury is one of the urological emergencies. Surgery and conservative management are major treatment methods but are always accompanied by many complications. Aim To investigate the feasibility of repairing cavernous tissues in acute rabbit penile cavernosal injury model with vascular endothelial growth factor (VEGF)-expressing muscle-derived stem cells (MDSCs). Methods MDSCs were isolated and transfected with hVEGF165 lentiviral gene vector in vitro. The expression of VEGF was confirmed using enzyme-linked immunosorbent assay (ELISA), Western blot, and real-time polymerase chain reaction (PCR) analyses. After animal models were constructed, animals were randomly divided into four groups, which were administrated with MDSCs/VEGF, MDSCs/vector, MDSCs, and normal saline, respectively. A month later, magnetic resonance imaging (MRI) and intracavernosal pressures (ICP) were performed on the animals. Then penile tissues were harvested and assayed with Western blot and immunohistochemistry. Main Outcome Measures Real-time PCR, Western blot, ELISA, immunohistochemistry, MRI, and ICP were performed in our experiments. Results The expression of VEGF significantly increased in the VEGF-expressing MDSCs group compared with those in the MDSCs/vector and MDSCs groups. VEGF protein expression in the injury sites of cavernous tissues were significantly higher in the MDSCs/VEGF group compared with those in other three groups. Immunohistochemical staining showed that α-smooth muscle actin-positive cells, von Willebrand factor-positive cells and capillary density markedly increased in the MDSCs/VEGF group. Animals receiving MDSCs/VEGF showed a significant improvement in cavernosal contractile function and structural repair. Conclusions The transplantation of VEGF-expressing MDSCs could repair the actuely injured cavernous tissue. We believed that it could be a novel therapeutic strategy for acute rabbit penile cavernosal injury.

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“…Ultrasonography and more recently magnetic resonance imaging (MRI) have been recommended when the diagnosis is uncertain. [67]…”

Section: Discussionmentioning

confidence: 99%

Penile abscess and necrotizing fasciitis secondary to neglected false penile fracture

2010

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The Value of Magnetic Resonance Imaging in the Diagnosis of Suspected Penile Fracture with Atypical Clinical Findings

Abstract: MRI is the most accurate imaging procedure when penile fracture is suspected but clinical findings are unusual.

Cited by 97 publications

References 11 publications

Point-of-care ultrasound used to exclude penile fracture

Point-of-care ultrasound used to exclude penile fracture

The Therapeutic Role of VEGF-Expressing Muscle-Derived Stem Cells in Acute Penile Cavernosal Injury

Penile abscess and necrotizing fasciitis secondary to neglected false penile fracture

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