The value of SCORAD and beyond. Towards a standardized evaluation of severity?

Abstract

The clinical scoring systems of atopic dermatitis were analysed and compared. Some biological parameters that can correlate with the clinical score were also reviewed. After the definition of the disease based on validated clinical criteria, the second necessity was the availability of reliable severity scores to allow clinicians to verify the course of the disease and the efficacy of treatments. After many proposals, the SCORAD (SCORing Atopic Dermatitis), that required more than three years of work, was the first one that was validated. SCORAD is freely available from an internet site and can be easily calculated using dedicated software. EASI (Eczema Area and Severity Index) score has also been validated but it has been modified twice. Simpler systems include SASSAD (Six Area, Six Sign Atopic Dermatitis) and TIS score (Three-Item Severity score). In parallel, biological parameters were investigated. Eosinophil cationic protein, circulating basophils, major basic protein, soluble E-selectin, antistaphylococcal enterotoxin B, immunoglobulin E titres and macrophage-derived chemokine, can correlate significantly with the clinical score. The clinicians will not benefit directly from laboratory techniques and will employ clinical scores.

The sensory profile of children with atopic dermatitis as determined by the sensory profile questionnaire

“…The severity of AD was assessed using the objective Severity Scoring of AD (SCORAD), a validated tool combining the extent and intensity of clinical signs with subjective symptoms. 27 Sensory modulation assessment. The sensory modulation profile was assessed using the SSP, 28 which is a reliable and valid parent-report measure of functional behaviors associated with abnormal responses to sensory stimuli.…”

The severity of atopic dermatitis and the relation to the level of total IgE, onset of atopic dermatitis and family history about atopy

“…The acronym SCORAD was proposed by Arnold Oranje, and stands for SCORing AD (European Task Force on Atopic Dermatitis, 1993). By using this instrument, different studies are more comparable in routine practice, as well as in observational or double-blind randomized clinical trials (Gelmetti & Colonna, 2004).…”

Correlation between Objective SCORAD and Three-Item Severity Score Used by Physicians and Objective PO-SCORAD Used by Parents/Patients in Children with Atopic Dermatitis

“…Besides HRQoL measurements, severity rating scales are used to determine the impact of AD at a given time and to provide better treatment. The Scoring Atopic Dermatitis (SCORAD) index was developed by the European Task Force on Atopic Dermatitis (ETFAD) and is the most widely used and validated severity rating scale in AD and comprises both subjective as well as objective items [7,8,9,10,11]. Since the SCORAD index appeared to be time-consuming and complicated for use in daily practice, the Three-Item Severity (TIS) score was developed.…”