2011
DOI: 10.1016/j.ejogrb.2010.10.008
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The value of serological markers in the diagnosis and prognosis of endometriosis: a prospective case–control study

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Cited by 56 publications
(31 citation statements)
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“…Increased serum IL-6 levels observed in patients with minimal-mild endometriosis in our study are in line with findings of some reports [18][19][20] but depart from others that found no value for serum IL-6 in the diagnosis of endometriosis at any stage [21,22] and from yet others that reported slightly elevated serum IL-6 levels in controls [23][24][25]. Additionally, it is worthwhile to note that serum IL-6 was the only marker that was constantly elevated in all our comparison groups (endometriosis group, minimalmild endometriosis group and moderate-severe endometriosis group).…”
Section: Discussionsupporting
confidence: 82%
See 1 more Smart Citation
“…Increased serum IL-6 levels observed in patients with minimal-mild endometriosis in our study are in line with findings of some reports [18][19][20] but depart from others that found no value for serum IL-6 in the diagnosis of endometriosis at any stage [21,22] and from yet others that reported slightly elevated serum IL-6 levels in controls [23][24][25]. Additionally, it is worthwhile to note that serum IL-6 was the only marker that was constantly elevated in all our comparison groups (endometriosis group, minimalmild endometriosis group and moderate-severe endometriosis group).…”
Section: Discussionsupporting
confidence: 82%
“…had increased plasma concentrations of inflammatory cytokines. Comparable TNF-α [20,[23][24][25]] levels were previously reported in women with and without endometriosis. However, other investigators reported elevated levels of TNF-α and Epo in endometriosis patients compared with controls [13,18,26].…”
Section: Discussionmentioning
confidence: 50%
“…[23][24][25] Although laparoscopy is the gold-standard diagnostic method, $66% of women who undergo laparoscopy are found to be free of the disease. Taken together with the potential risks and cost associated with laparoscopy, 26 the development of a noninvasive diagnostic method would have a huge impact on patients' health-related quality-of-life and reduce the number of unnecessary interventions. 27 The current meta-analysis found that the serum CA125 concentration was associated with endometriosis in Caucasian, Asian and overall populations, and with both early and advanced stage disease.…”
Section: Discussionmentioning
confidence: 99%
“…Two main classes of caspases were described: caspases-9, known as initiator caspases, and caspases-3, known as effector caspases. Apoptosis may be triggered by the interaction among Fas ligand (FasL/ CD95L) [16], tumor necrosis factor α (TNF-α) [23], transforming growth factor β (TGF-β), cytokines and overexpression or inappropriate expression of c-MYC and p53 [24].…”
Section: Discussionmentioning
confidence: 99%