The variability of hepatitis B envelope is associated with HBs antigen persistence in either chronic or acute HBV genotype A infection

Eschlimann, Marine; Malvé, Brice; Velay, Aurélie; Fenaux, Honorine; Berger, Sibel; Frippiat, Jean-Pol; Zoulim, Fabien; Bensenane, Mouni; Bronowicki, Jean–Pierre; Goehringer, François; May, Thierry; Jeulin, Hélène; Schvoerer, Évelyne

doi:10.1016/j.jcv.2017.08.001

Cited by 5 publications

(6 citation statements)

References 33 publications

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“…The mutation that occurred in aa123 was mainly associated with impaired secretion of HBsAg and led to occult HBV infection. sI110L sF161Y had been found in a previous study on immune escape mutations (30)(31)(32). However, both two mutations were only found in genotype C in the current study, and sI110L was only observed in genotype B in a previous study, whether it was crucial for immune escape, was unknown in genotype B.…”

Section: Discussioncontrasting

confidence: 44%

Deep Sequencing Reveals the Characteristics of Hepatitis B Virus (HBV) S Region in Vertical Transmission and the Influence of Mutations on Vaccination Failure

Zou

Peng

et al. 2019

Hepat Mon

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Background: Immune escape mutation is a major reason for vaccination failure in vertical transmission of hepatitis B virus (HBV). Objectives: The aim of the current study was to explore the characteristics of HBV S region gene in vertical transmission and the influence of mutations on vaccination failure in HBV S region gene. Methods: A total of nine mother-child pairs with chronic HBV were recruited in this study, and all of the children received the vaccine. Next-generation sequencing (NGS) was used to investigate the sequences of HBV S gene from the mother and children. Results: The analysis of the sequencing data showed that all mother-child pairs are genotype B and genotype C mixed infection and the dominant genotype did not change in vertical transmission, and the consensus sequences of mothers and children were highly similar. Furthermore, the diversity of most amino acid sites had a small difference between mothers and children, and the mutations shared by mothers and children made up a high proportion of children's mutations; the rate was 83.13% ± 8.45%. Also, the research found many mutations that could cause immune escape in major hydrophilic region. Especially in "a" determinant, sC137S or sC139Y, which had an important influence on the structure of "a" determinant, were observed in all mother-child pairs. Conclusions: All the above results indicated that HBV S gene was highly conserved in vertical transmission, and these immune escape mutations that pre-exist in mothers were transmitted to children and resulted in vaccination failure.

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Section: Discussioncontrasting

confidence: 44%

Deep Sequencing Reveals the Characteristics of Hepatitis B Virus (HBV) S Region in Vertical Transmission and the Influence of Mutations on Vaccination Failure

Zou

Peng

et al. 2019

Hepat Mon

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“…Analysis of HBV sequences from a family transmission network found the precore and middle region of the S gene to be hotspots for sequence diversity compared with the relative conservation of these regions between genotypes 112 . Opposing effects on HBV genetic diversity are presented in Table 2 43, 63, 64, 74, 102, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125Table 2Determinants of Diversity and Conservation Within HBVHBV attributeFactors associated with sequence conservationFactors associated with sequence diversityGenome structure and sequenceOverlapping ORFs and regulatory regions in viral genome (Figures 2 A and 3 B ) impose constraint on viral plasticity 102 because nonsynonymous mutations have to be accommodated within 2 different proteins to be viable; this makes most mutations disadvantageous, 113 an example of constrained evolution 114 .…”

Section: Virus Evolution and Diversitymentioning

confidence: 99%

“…Persistence and transmissionSuperior transmission potential of wild-type variants 118 Transmission bottlenecks limit diversity at onset of new infections 119, 120Long duration of infection can generate diverse quasispecies populations within hosts 119, 120, 121…”

Section: Virus Evolution and Diversitymentioning

confidence: 99%

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Insights From Deep Sequencing of the HBV Genome—Unique, Tiny, and Misunderstood

et al. 2019

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Hepatitis B virus (HBV) is a unique, tiny, partially double-stranded, reverse-transcribing DNA virus with proteins encoded by multiple overlapping reading frames. The substitution rate is surprisingly high for a DNA virus, but lower than that of other reverse transcribing organisms. More than 260 million people worldwide have chronic HBV infection, which causes 0.8 million deaths a year. Because of the high burden of disease, international health agencies have set the goal of eliminating HBV infection by 2030. Nonetheless, the intriguing HBV genome has not been well characterized. We summarize data on the HBV genome structure and replication cycle, explain and quantify diversity within and among infected individuals, and discuss advances that can be offered by application of next-generation sequencing technology. In-depth HBV genome analyses could increase our understanding of disease pathogenesis and allow us to better predict patient outcomes, optimize treatment, and develop new therapeutics.

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“…HBV envelope variability may play a role, because more frequent mutations in the major hydrophilic region have been observed in those who have lost HBsAg (such mutations may have a key role in immune recognition and antigenicity). 15 Patients with detectable basal core promoter/precore variants and higher viral diversity showed a lower probability of HBsAg loss during NUC therapy. 16 Increased natural killer cell functionality and HBV-specific T-cell responsiveness have been shown in patients experiencing HBsAg seroclearance after stopping NUC therapy.…”

mentioning

confidence: 97%

Hepatitis B Surface Antigen Loss: Too Little, Too Late and the Challenge for the Future

Dusheiko

Wang

2019

Gastroenterology

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Standardized long-term follow-up after endoscopic resection of large, nonpedunculated colorectal lesions: a prospective two-center study. Am J Gastroenterol 2014;109:183-189. 6. Moss A, Williams SJ, Hourigan LF, et al. Long-term adenoma recurrence following wide-field endoscopic mucosal resection (WF-EMR) for advanced colonic mucosal neoplasia is infrequent: results and risk factors in 1000 cases from the Australian Colonic EMR (

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The variability of hepatitis B envelope is associated with HBs antigen persistence in either chronic or acute HBV genotype A infection

Cited by 5 publications

References 33 publications

Deep Sequencing Reveals the Characteristics of Hepatitis B Virus (HBV) S Region in Vertical Transmission and the Influence of Mutations on Vaccination Failure

Deep Sequencing Reveals the Characteristics of Hepatitis B Virus (HBV) S Region in Vertical Transmission and the Influence of Mutations on Vaccination Failure

Insights From Deep Sequencing of the HBV Genome—Unique, Tiny, and Misunderstood

Hepatitis B Surface Antigen Loss: Too Little, Too Late and the Challenge for the Future

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