The Venous Clinic

Belcaro, Gianni; Nicolaides, Andrew; Stansby, Gerard

doi:10.1142/p041

Cited by 17 publications

(30 citation statements)

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“…The evaluation methods were previously reported in detail (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). In the included patients, venous reflux in the popliteal vein was shown by colour duplex ultrasonography.…”

Section: Discussionmentioning

confidence: 99%

“…In the included patients, venous reflux in the popliteal vein was shown by colour duplex ultrasonography. The increase in venous pressure was measured by AVP (10)(11)(12)(13)(14)(15)(16)(17)(18). High AVP was due to combined superficial and deep venous incompetence.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with severe CVI (intravenous ambulatory venous pressure [AVP] greater than 56 mmHg, refilling time shorter than 10 s and deep venous incompetence shown by colour duplex ultrasonography) who co-operated with the study protocol were included (10,12). Patients with severe CVI, and ankle or foot swelling (11,18), were included after a washout period of two weeks.…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…Subjects with recent venous thrombosis or arterial diseases (10,12) confirmed by ultrasound were excluded. Patients with a history of thrombosis in the previous 24 months were also excluded, as were patients with lymphatic disorders and patients whose body mass index (BMI) was greater than 26.…”

Section: Exclusion Criteriamentioning

confidence: 99%

“…Microcirculatory evaluation in CVI (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) may quantitate improvements in microangiopathy produced by HR in the distal lower limb (perimalleolar region) (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30).…”

mentioning

confidence: 99%

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Five-year treatment of chronic venous insufficiency with O-(β-hydroxyethyl)-rutosides: Safety aspects

Stuard¹,

Cesarone

Belcaro

et al. 2008

Int J Angiol

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Chronic venous insufficiency (CVI), and related signs and symptoms of venous and diabetic microangiopathy, can be effectively treated with O-(β-hydroxyethyl)-rutosides (HR). The aim of the present independent registry study was to evaluate HR in a long-term (five-year) period of administration that examined the tolerability and safety of HR. Patients with severe CVI and venous microangiopathy were included in the registry. Subjects who completed five years of treatment were considered in the analysis. Blood parameters, liver and renal function tests, microalbuminuria (in diabetic patients) and cholesterol levels were evaluated to assess the effects of HR treatment. Four groups were studied - group A (98 patients) received oral HR (1500 mg per day), group B (87 diabetic patients with CVI) was treated with 2 g of HR per day, group C (90 controls, including 42 diabetic patients) had no pharmacological treatment and group D (113 patients, including 48 diabetic patients) used elastic stockings. No significant negative changes in blood parameters were recorded at two and five years. Decreases in microalbuminuria and total cholesterol, and an increase in high-density lipoprotein cholesterol were observed in HR-treated patients, particularly in diabetic patients. Minimal (nonsignificant) variations were observed in the groups that did not use HR. In conclusion, HR treatment is safe, and some positive effects from HR on cholesterol levels and microalbuminuria (in diabetic patients) that were previously observed may suggest potential new clinical applications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Inclusion Criteriamentioning

confidence: 99%

Section: Exclusion Criteriamentioning

confidence: 99%

mentioning

confidence: 99%

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Five-year treatment of chronic venous insufficiency with O-(β-hydroxyethyl)-rutosides: Safety aspects

Stuard¹,

Cesarone

Belcaro

et al. 2008

Int J Angiol

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Photoplethysmograhic sensors, potential and limitations: Is it time for regulation? A comprehensive review

et al. 2023

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Effects of elastic compression stockings on wall shear stress in deep and superficial veins of the calf

Downie¹,

Raynor²,

Firmin³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

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The purpose of this study was to estimate wall shear stress (WSS) in individual vessels of the venous circulation of the calf and quantify the effects of elastic compression based on change of vessel geometry and velocity waveform. The great saphenous vein and either a peroneal or posterior tibial vein have been imaged in four healthy subjects using magnetic resonance imaging, with and without the presence of a grade 1 medical stocking. Flow through image-based reconstructed geometries was numerically simulated for both a range of steady flow rates and ultrasound-derived transient velocity waveforms, scaled to give a standardized time averaged flow rate. For steady flow, the stocking produced an average percentage increase in mean WSS of approximately 100% in the great saphenous vein across a range of 0.125-1.25 ml/s. The percentage increase in the peroneal/posterior tibial veins varied from 490 to 650% across a range of 0.5-5 ml/s. In addition, application of the stocking eliminated periods of very low or zero flow from the transient waveforms. The average minimum value of WSS in all vessels without the stocking was <0.1 Pa. With the stocking, this was increased to 0.7 Pa in the great saphenous and 0.9 Pa in the peroneal/posterior tibial veins. The pathophysiological effects of these changes are discussed. In conclusion, the flight stocking was effective in raising venous WSS levels in prone subjects, and this effect was much more pronounced in the deep vessels. The stocking also tended to prevent cessation of flow during periods of increased downstream pressure produced by respiration.

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The Venous Clinic

Cited by 17 publications

References 0 publications

Five-year treatment of chronic venous insufficiency with O-(β-hydroxyethyl)-rutosides: Safety aspects

Five-year treatment of chronic venous insufficiency with O-(β-hydroxyethyl)-rutosides: Safety aspects

Photoplethysmograhic sensors, potential and limitations: Is it time for regulation? A comprehensive review

Effects of elastic compression stockings on wall shear stress in deep and superficial veins of the calf

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