2020
DOI: 10.1101/2020.12.29.424736
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The β-Carotene-Oxygen Copolymer: its Relationship to Apocarotenoids and β-Carotene Function

Abstract: Abstractβ-Carotene spontaneously copolymerizes with molecular oxygen to form a β-carotene-oxygen copolymer compound (“copolymer”) as the main product, together with small amounts of many apocarotenoids. Both the addition and scission products are interpreted as being formed during progression through successive free radical β-carotene-oxygen adduct intermediates. The product mixture from full oxidation of β-carotene, lacking both vitamin A and β-carotene, has immunological activities, some of which derive from… Show more

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Cited by 2 publications
(12 citation statements)
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“…The in vivo mouse results strongly suggest that any potentially reactive compounds present in OxBC, such as peroxides, as have been measured in plant food items (Schaub et al, 2017), and reactive carbonyl compounds (Mogg and Burton, 2020), are safely metabolized.…”
Section: Discussionmentioning
confidence: 93%
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“…The in vivo mouse results strongly suggest that any potentially reactive compounds present in OxBC, such as peroxides, as have been measured in plant food items (Schaub et al, 2017), and reactive carbonyl compounds (Mogg and Burton, 2020), are safely metabolized.…”
Section: Discussionmentioning
confidence: 93%
“…For comparison the level of exposure in OxBC livestock feeding trials ranges from 2-8 ppm. As some of the small apocarotenoid compounds present in OxBC are potentially chemically reactive electrophiles and carbonyls (Burton et al, 2014; Mogg and Burton, 2020), it is not unexpected that some degree of mutagenicity is seen at higher concentrations. The higher threshold for mutagenicity seen with metabolic activation (i.e., > 500 μg/plate) supports the possibility that metabolism would at least partially mitigate the reactivity of OxBC’s reactive components.…”
Section: Discussionmentioning
confidence: 99%
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