Theoretical analysis of steady state recycling chromatography with solvent removal

Design of batch chromatography for separation of binary mixtures under reduced purity requirements

“…It is similar to that used by Golshan-Shirazi and Guiochon [2] for systems with Langmuir isotherm in a special case where only the second component is the target. A similar method was also used by Sainio and Kaspereit [14] to design mixed-recycle steady state recycling chromatography (MR-SSR), by Siitonen et al [16] to design MR-SSR with an integrated solvent removal unit, and by Siitonen et al [17] to design bypass chromatography. In this work, however, the approach is applied to batch separations where two product fractions without generation of waste or recycle fractions are desired.…”

Robustness of steady state recycling chromatography with an integrated solvent removal unit

“…Many potential chromatography-based hybrid concepts have been proposed such as coupling of chromatography with crystallization [1][2][3][4][5][6][7][8][9], chemical reactions [10][11][12][13][14][15][16][17], partial solvent removal [18][19][20][21][22], or combinations of them [23,24].…”

“…In this work, we will focus on analysing the robustness of a hybrid separation process where mixed-recycle SSR chromatography is integrated with a solvent removal unit (SSR-SR) [20]. In SSR-SR concept, the internal recycling stream of SSR unit is concentrated by removing part of the solvent, for example, with membrane filtration or evaporation.…”

“…In SSR-SR concept, the internal recycling stream of SSR unit is concentrated by removing part of the solvent, for example, with membrane filtration or evaporation. This leads to increased productivity and decreased eluent consumption as demonstrated in [20][21][22]. In earlier works [20,22], a method has been developed to calculate the optimal cut times as well as the range of feasible solvent removal capacity and the volume of the feed pulse that corresponds to arbitrary purity and solvent removal constraints by using the equilibrium theory of chromatography.…”

“…For this purpose, the Unified Design approach [32] is used to present the method developed earlier for the design of SSR-SR setup [20,22] in a form analogous to the triangle theory in order to analyse the robustness of the SSR-SR process. The effect of solvent removal capacity on the range of feasible cut times is of special interest.…”