Theoretical investigation of the potentialities of the use of a multidimensional column in chromatography

Guiochon, Georges; Beaver, Lois Ann; Gonnord, M. F.; Siouffi, A. M.; Zakaria, Mona

doi:10.1016/s0021-9673(01)88298-4

Cited by 120 publications

(64 citation statements)

References 25 publications

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“…However, the landmark publications demonstrating the feasibility of 2D separation in liquid chromatography came around 1980 with a pair of papersdone by Apffel et al (1981) and one by . These proof-of-concept papers, along with several influential papers from this period on the theory of 2D separation (Giddings, 1987(Giddings, , 1984Guiochon et al, 1983;Snyder et al, 1981) undoubtedly captured the imagination of a generation of chromatographers. The demonstration of heartcutting 2D-LC (LCeLC) by Majors et al led to the development of thousands of methods for quantitation of target compounds in complex mixtures, sometimes at the trace level.…”

Section: Figure 75mentioning

confidence: 99%

Theory and Practice of UHPLC and UHPLC–MS

Guillarme

Veuthey

2017

Handbook of Advanced Chromatography /Mass Spectrometry Techniques

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Section: Figure 75mentioning

confidence: 99%

Theory and Practice of UHPLC and UHPLC–MS

Guillarme

Veuthey

2017

Handbook of Advanced Chromatography /Mass Spectrometry Techniques

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“…Among them the most important ones are the integrated systems containing complementary dimensions, where different dimensions separate components on the basis of independent or orthogonal principles (Moore & Jorgenson, 1995;Lemmo & Jorgenson, 1993;Mohan & Lee, 2002). In such a multidimensional system, the peak capacity is the product of the peak capacities of each dimension (Guiochon et al, 1983). A key part in the instrumentation of the hyphenated techniques is an appropriate interface that enables to connect and disconnect two different stages (e.g.…”

Section: Advanced Single Column Techniquesmentioning

confidence: 99%

Column Coupling Electrophoresis in Biomedical Analysis

Mikuš¹,

Maráková²

2011

Biomedical Engineering - From Theory to Applications

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“…2-D systems are often designed in order to accomplish sample separation according to the distribution of different characteristic sample properties [19].…”

Section: Peak Capacity In Single-and 2-d Lcmentioning

confidence: 99%

Column selectivity for two‐dimensional liquid chromatography

Jandera¹

2006

J of Separation Science

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Selectivity of phase system is of primary concern when designing a 2-D separation, as it affects the 2-D system orthogonality and consequently the peak capacity controlling the number of peaks that can be separated in the available 2-D retention space limited by the time of analysis. Possibilities for characterization of LC phase system selectivity with respect to different polar and nonpolar structural units are compared, with special attention to multidimensional samples with various types of repeat groups, such as homopolymers, (co)polymers, fatty acid esters with various acyl lengths and number and position of double bonds, etc. Possibilities of the 2-D LC separations of these and other sample types, including pharmaceuticals, natural phenolic compounds, biopolymers, etc., using various combinations of separation modes are reviewed. Rules for design of comprehensive 2-D LC x LC systems are discussed, with respect to mobile phase compatibility in the two systems and modulation techniques suppressing band broadening connected with the sample fraction transfer from the first to the second dimension. Pitfalls connected with online connection of normal-phase and RP LC systems and their possible practical solutions are addressed and illustrated by practical examples.

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Theoretical investigation of the potentialities of the use of a multidimensional column in chromatography

Cited by 120 publications

References 25 publications

Theory and Practice of UHPLC and UHPLC–MS

Theory and Practice of UHPLC and UHPLC–MS

Column Coupling Electrophoresis in Biomedical Analysis

Column selectivity for two‐dimensional liquid chromatography

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