“Theory of mind” is impaired in Huntington's disease

Brüne, Martin; Blank, Karina; Witthaus, Henning; Saft, Carsten

doi:10.1002/mds.23494

Cited by 55 publications

(46 citation statements)

References 39 publications

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“…Although HD patients had no difficulty attributing an independent mental state to other individuals, they tended to make incorrect, and often unusual, conclusions about these individuals' beliefs or thoughts. Two subsequent studies reported significant ToM impairment in HD patients relative to healthy controls 129 130. However, the HD cohorts in both studies had significant executive impairment, which correlated with at least some of their ToM scores 129 130…”

Section: Social Cognition In Neurodegenerative Diseasesmentioning

confidence: 97%

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Social cognition in neurodegenerative disorders: a systematic review

Elamin

Pender

Hardiman

et al. 2012

J Neurol Neurosurg Psychiatry

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Social cognitive neuroscience is the study of the neurobiological systems underlying effective social behaviour. The neural processes supporting effective social interactions in everyday life and the consequences of dysfunction in these processes have been the focus of intense research over the last two decades. It is becoming increasingly apparent that the identification of social cognitive deficits in neurodegenerative conditions and their neural basis may provide a better understanding of the behavioural changes observed in these disorders. In addition, accumulating data suggest that detection of early impairment in social cognitive skills may aid in the early diagnosis of cognitive or behavioural impairment in some of these disorders, and may even play a role in the investigation of new therapeutic options. In this review, we outline the basic components of social cognitive processing, provide a systematic review of the literature pertaining to common neurodegenerative conditions, discuss current controversies and make recommendations for future research.

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Section: Social Cognition In Neurodegenerative Diseasesmentioning

confidence: 97%

“…Two subsequent studies reported significant ToM impairment in HD patients relative to healthy controls 129 130. However, the HD cohorts in both studies had significant executive impairment, which correlated with at least some of their ToM scores 129 130…”

Section: Social Cognition In Neurodegenerative Diseasesmentioning

confidence: 97%

Social cognition in neurodegenerative disorders: a systematic review

Elamin

Pender

Hardiman

et al. 2012

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

show abstract

“…ToM impairments have also recently been demonstrated in early PD [44], though their deficit has not yet been clearly characterized [45]. HD patients also show deficits on both cognitive and emotional ToM tests[12,46], though it remains unclear whether these deficits result from executive dysfunction [46] or remain after accounting for intellectual and executive functioning [47]. …”

Section: Higher-order Social Information Processingmentioning

confidence: 99%

Personality and social cognition in neurodegenerative disease

Shany‐Ur

Rankin

2011

Current Opinion in Neurology

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Purpose of review Neurodegenerative diseases often cause focal damage to brain structures mediating social cognition and personality, resulting in altered interpersonal communication and behavior. We review recent research describing this phenomenon in various aspects of social cognition. Recent findings Corresponding to their pervasive social-emotional deficits, patients with frontotemporal dementia perform poorly on lab-based tasks including recognizing emotions, attending to salient information that guides social behavior, representing social knowledge, comprehending others’ mental states, and maintaining insight to their own difficulties. Together with poor executive and regulation mechanisms, these social cognition deficits ultimately impact behavior. Patients with logopenic and nonfluent primary progressive aphasia have some deficits recognizing emotional prosody, while those with the semantic variant show more widespread deficits in social comprehension. While Alzheimer’s disease patients perform poorly on some social cognition tasks, this typically reflects general cognitive impairment, and their real-life social functioning is less affected than in diseases targeting frontotemporal structures. Studies in motor diseases such as Parkinson’s suggest some degradation of emotion recognition and social comprehension which should be investigated further. Summary We summarize recent findings concerning perception and evaluation of socioemotional information, social knowledge storage and access, advanced information processing mechanisms, and behavioral response selection and regulation across various neurodegenerative diseases.

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“…Accordingly, we aimed to study differences in activation between cognitive and affective ToM using an established cartoon‐based ToM paradigm [Brüne et al, ; Lissek et al, ; Saft et al, ]. In particular, we sought to present identical stimulus material for the cognitive, the affective, and the control (“physical”) condition.…”

Section: Introductionmentioning

confidence: 99%

Shared and nonshared neural networks of cognitive and affective theory-of-mind: A neuroimaging study using cartoon picture stories

et al. 2014

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Theory of mind (ToM) refers to the ability to represent one's own and others' cognitive and affective mental states. Recent imaging studies have aimed to disentangle the neural networks involved in cognitive as opposed to affective ToM, based on clinical observations that the two can functionally dissociate. Due to large differences in stimulus material and task complexity findings are, however, inconclusive. Here, we investigated the neural correlates of cognitive and affective ToM in psychologically healthy male participants (n = 39) using functional brain imaging, whereby the same set of stimuli was presented for all conditions (affective, cognitive and control), but associated with different questions prompting either a cognitive or affective ToM inference. Direct contrasts of cognitive versus affective ToM showed that cognitive ToM recruited the precuneus and cuneus, as well as regions in the temporal lobes bilaterally. Affective ToM, in contrast, involved a neural network comprising prefrontal cortical structures, as well as smaller regions in the posterior cingulate cortex and the basal ganglia. Notably, these results were complemented by a multivariate pattern analysis (leave one study subject out), yielding a classifier with an accuracy rate of more than 85% in distinguishing between the two ToM-conditions. The regions contributing most to successful classification corresponded to those found in the univariate analyses. The study contributes to the differentiation of neural patterns involved in the representation of cognitive and affective mental states of others.

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“Theory of mind” is impaired in Huntington's disease

Abstract: The present study shows that patients with HD have deficits in ToM similar to schizophrenia. The association of impaired ToM with function needs to be established in future studies using rating scales that more specifically address interpersonal problems.

Cited by 55 publications

References 39 publications

Social cognition in neurodegenerative disorders: a systematic review

Social cognition in neurodegenerative disorders: a systematic review

Personality and social cognition in neurodegenerative disease

Shared and nonshared neural networks of cognitive and affective theory-of-mind: A neuroimaging study using cartoon picture stories

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