Therapeutic applications of bacterial pigments: a review of current status and future opportunities

Numan, Muhammad; Bashir, Samina; Mumtaz, Roqayya; Tayyab, Sibgha; Rehman, Najeeb Ur; Khan, Abdul Latif; Shinwari, Zabta Khan; Al‐Harrasi, Ahmed

doi:10.1007/s13205-018-1227-x

Cited by 89 publications

(63 citation statements)

References 91 publications

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“…The worldwide concern recently has been to extend inclination towards the use of natural materials in place of artificial ones because of several advantages including concerns over environmentally-friendly sustenance [ 77 , 79 ]. Consequently, the uses of bacterial pigments have expanded much more than synthetic pigments [ 80 ]. Prodiginines (PGs), a family of red microbial pigments, have received much attention because of their considerable bioactivities [ 59 , 60 , 61 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 ,...…”

Section: Introductionmentioning

confidence: 99%

Production and Potential Applications of Bioconversion of Chitin and Protein-Containing Fishery Byproducts into Prodigiosin: A Review

et al. 2020

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The technology of microbial conversion provides a potential way to exploit compounds of biotechnological potential. The red pigment prodigiosin (PG) and other PG-like pigments from bacteria, majorly from Serratia marcescens, have been reported as bioactive secondary metabolites that can be used in the broad fields of agriculture, fine chemicals, and pharmacy. Increasing PG productivity by investigating the culture conditions especially the inexpensive carbon and nitrogen (C/N) sources has become an important factor for large-scale production. Investigations into the bioactivities and applications of PG and its related compounds have also been given increased attention. To save production cost, chitin and protein-containing fishery byproducts have recently been investigated as the sole C/N source for the production of PG and chitinolytic/proteolytic enzymes. This strategy provides an environmentally-friendly selection using inexpensive C/N sources to produce a high yield of PG together with chitinolytic and proteolytic enzymes by S. marcescens. The review article will provide effective references for production, bioactivity, and application of S. marcescens PG in various fields such as biocontrol agents and potential pharmaceutical drugs.

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Section: Introductionmentioning

confidence: 99%

Production and Potential Applications of Bioconversion of Chitin and Protein-Containing Fishery Byproducts into Prodigiosin: A Review

et al. 2020

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“…The pursuit of alternative sources as functional food (that serves the dual purpose of nutrition and diet) has led to the spurred market drive for carotenoid (Numan et al 2018a). Carotenoids reported from plant, algae, yeast and some bacteria possess high antioxidant property that circumvents cellular damages arising from oxidative stress (Freile-Pelegrín and Robledo 2013;Landete 2013).…”

Section: Introductionmentioning

confidence: 99%

Ameliorating process parameters for zeaxanthin yield in Arthrobacter gandavensis MTCC 25325

et al. 2020

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The present study aims to escalate the production of prophylactic agent zeaxanthin using a screened potential bacterial isolate. For this purpose, a freshwater bacterium capable of producing zeaxanthin was isolated from Bor Talav, Bhavnagar. The 16S rRNA sequence confirmed the isolate as Arthrobacter gandavensis. The bacterium was also submitted to Microbial Type Culture Collection, CSIR-Institute of Microbial Technology, Chandigarh, India, with the accession number MTCC 25325. The chemo-metric tools were employed to optimise the influencing factors such as pH, temperature, inoculum size, agitation speed, carbon source and harvest time on zeaxanthin yield. Thereafter, six parameters were narrowed down to three factors and were optimised using the central composite design (CCD) matrix. Maximum zeaxanthin (1.51 mg/g) was derived when A. gandavensis MTCC 25325 was grown under pH 6.0, 1.5% (w/v) glucose and 10% (v/v) inoculum size. A high regression coefficient (R 2 = 0.92) of the developed model indicated the accurateness of the tested parameters. To the best of our knowledge, this is the first report on tailoring the process parameters using chemo-metric optimisation for escalating the zeaxanthin production by A. gandavensis MTCC 25325.

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Section: Introductionmentioning

confidence: 99%

“…The antimicrobial activities of pigments could be used in development of antimicrobial drugs and may have various industrial, pharmaceutical and medical applications 4 . Pigmented secondary metabolites have been reported to possess potential clinical applications in treatment of human diseases 4 . The bacterial pigments demonstrated significant anti-inflammatory, antimalarial, anti-cancerous, immunosuppressive as well as antimicrobial activities 5 .…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Marine Bacterial Pigments Obtained from Arabian Sea Water Samples

Patel¹,

Dwivedi²,

Jadeja³

et al. 2020

J. Pure Appl. Microbiol.

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The Arabian Sea environment harbors numerous microorganisms that have developed unique metabolic abilities to ensure their survival in hostile habitats. The bacterial pigments are considered to be important metabolic product which is useful for bacteria and may exert specific biological properties including antibacterial activity. Moreover, there is an imperative need for exploring new antibacterial agents since; there are drug resistance issues with the existing antibiotics. Therefore, the present study was aimed to assess antibacterial activity of pigments extracted from marine bacteria of Arabian Sea water samples and to characterize the potent antibacterial pigment producing isolate. The water samples were obtained from Tithal (Valsad), Diu, Daman and Dandi beaches of India. Total 9 distinct pigmented bacteria were isolated. The pigments extracted from bacterial isolates were assessed for the antibacterial, antioxidant and anticancer activities. Four pigment producing isolates (NP5, NP6, NP8 & NP9) among the nine isolates showed good antibacterial activity against the different bacterial cultures. Among these four isolates, NP9 showed maximum antibacterial activity against all the test cultures. The pigment obtained from NP5 isolate exhibited higher antioxidant property as compared to NP6, NP8 and NP9. However, none of the pigments obtained from NP5, NP6 and NP9 exhibited anti-cancerous activity on MCF-7 cell line. The molecular identification by16srDNA sequencing revealed that NP9 belongs to Candidatus chryseobacterium massiliae (MK213063). Chryseobacterium has been known to produce yellow pigment; however, for the first time, the study suggests that Candidatus chryseobacterium massiliae strain produces red pigment with potent antibacterial activity. However, its antibacterial activity must be tested with more number of pathogens and study in disease animal model is needed to confirm the results of the study.

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Therapeutic applications of bacterial pigments: a review of current status and future opportunities

Cited by 89 publications

References 91 publications

Production and Potential Applications of Bioconversion of Chitin and Protein-Containing Fishery Byproducts into Prodigiosin: A Review

Production and Potential Applications of Bioconversion of Chitin and Protein-Containing Fishery Byproducts into Prodigiosin: A Review

Ameliorating process parameters for zeaxanthin yield in Arthrobacter gandavensis MTCC 25325

Antibacterial Activity of Marine Bacterial Pigments Obtained from Arabian Sea Water Samples

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