2021
DOI: 10.3390/ijms22168674
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Therapeutic Approaches Targeting Proteostasis in Kidney Disease and Fibrosis

Abstract: Pathological insults usually disturb the folding capacity of cellular proteins and lead to the accumulation of misfolded proteins in the endoplasmic reticulum (ER), which leads to so-called “ER stress”. Increasing evidence indicates that ER stress acts as a trigger factor for the development and progression of many kidney diseases. The unfolded protein responses (UPRs), a set of molecular signals that resume proteostasis under ER stress, are thought to restore the adaptive process in chronic kidney disease (CK… Show more

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Cited by 18 publications
(16 citation statements)
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References 144 publications
(158 reference statements)
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“…To test whether pharmacological interventions discovered during KSI can be transferred to NMP, we investigated drugs proposed to work against ER stress ( Gao et al, 2013 ; Chen et al, 2021 ; Xu et al, 2021 ): Salubrinal, Isoproterenol, Roflumilast, UDCA and β-Nicotinamide-adenine-dinucleotide. Surprisingly, salubrinal, isoproterenol, roflumilast, and UDCA did not show significant improvements in KSI ( Figure 3A ) ( Supplementary Table S1 ).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…To test whether pharmacological interventions discovered during KSI can be transferred to NMP, we investigated drugs proposed to work against ER stress ( Gao et al, 2013 ; Chen et al, 2021 ; Xu et al, 2021 ): Salubrinal, Isoproterenol, Roflumilast, UDCA and β-Nicotinamide-adenine-dinucleotide. Surprisingly, salubrinal, isoproterenol, roflumilast, and UDCA did not show significant improvements in KSI ( Figure 3A ) ( Supplementary Table S1 ).…”
Section: Resultsmentioning
confidence: 99%
“…To test whether pharmacological interventions discovered during KSI can be transferred to NMP, we investigated drugs proposed to work against ER stress (Gao et al, 2013;Chen et al, 2021;Xu et al, 2021): Salubrinal, Isoproterenol, Roflumilast, UDCA and β-Nicotinamide-adeninedinucleotide.…”
Section: Nadh Ameliorates Er Stress In Kidney Slice Incubator and Mou...mentioning
confidence: 99%
“…OTA treatment also induced p-eIF2α-mediated translational shut-down without CHOP activation (Figure 5). One of our recent works systemically reviewed the therapeutic approaches targeting proteostasis in kidney disease and fibrosis [32]. Therefore, several points deserve discussion with the aim of finding potential interventions in ER-mediated kidney injury under OTA exposure.…”
Section: Discussionmentioning
confidence: 99%
“…Although ER stress-mediated apoptosis that occurs after inflammation has been investigated in the brain, heart, and kidney tissues [ 8 , 15 , 16 ], its role in the cornea has not been studied. PubMed and Google Scholar were searched between January and May 2019.…”
Section: Introductionmentioning
confidence: 99%