Therapeutic effect of H. pylori nosode, a homeopathic preparation in healing of chronic H. pylori infected ulcers in laboratory animals

Gosavi, Tejas P.; Ghosh, Pranab; Kandhare, Amit D.; Kumar, V. Shiva; Adil, Malik M; Rajmane, Anuchandra Ramchandra; Bodhankar, Subhash L.

doi:10.1016/s2222-1808(12)60230-8

Cited by 36 publications

(14 citation statements)

References 31 publications

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“…63,64 It is considered that GSH act as cofactor for several protective enzymes that are important in defense mechanism of body from oxidative stress. 33,[65][66][67] There is association between the increase in blood pressure and the oxidative stress. Several clinical investigations showed that serum concentrations of MDA are high in the hypertensive patients than in normal individuals.…”

Section: Discussionmentioning

confidence: 99%

Flax lignan concentrate reverses alterations in blood pressure, left ventricular functions, lipid profile and antioxidant status in DOCA-salt induced renal hypertension in rats

Sawant

Bodhankar

2016

Renal Failure

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Context Earlier we reported cardioprotective, antihyperlipidemic, and in vitro antioxidant activity of flax lignan concentrate (FLC) obtained from the seeds of Linum usitatissimum L. (Linaceae). Objective To investigate the effect of FLC in deoxycorticosterone acetate (DOCA)-salt induced experimental renal hypertension in rats. Materials and methods Hypertension was induced in uninephrectomized (UNTZD) male Wistar rats (230-280 g) by injecting DOCA (25 mg/kg, subcutaneously, twice weekly) and supplementing 1% NaCl in drinking water for 5 weeks. The rats were divided in six groups. Captopril (30 mg/kg, p.o.) and FLC (200, 400 and 800 mg/kg, p.o.) were administered daily to the rats of groups III-VI, respectively, for 5 weeks. Various hemodynamic and biochemical parameters were investigated as well as histology of kidney and heart were carried out. Results In this study, the FLC (400 and 800 mg/kg) significantly (p50.01, p50.001) decreased the systolic blood pressure, diastolic blood pressure, and mean arterial blood pressure. It also significantly (p50.01, p50.001) decreased elevated end diastolic pressure (EDP), dP/dt max and dP/dt min, organs weights (kidney and heart) and activities of hepatic, renal and cardiac marker enzymes in the serum. Furthermore, FLC (400 and 800 mg/kg) significantly (p50.01, p50.001) restored altered antioxidant status, serum electrolyte level, lipid profile values, and histological abnormalities. Captopril (30 mg/kg) showed maximum antihypertensive effect but low dose of FLC (200 mg/kg) was not enough to show the antihypertensive activity. Conclusion FLC possessed antihypertensive effect via modulation of endogenous enzymes in DOCA-salt induced renal hypertension in rats.ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Flax lignan concentrate reverses alterations in blood pressure, left ventricular functions, lipid profile and antioxidant status in DOCA-salt induced renal hypertension in rats

Sawant

Bodhankar

2016

Renal Failure

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“…33,38 Nitric oxide (NO) has been implicated in an array of disorders including diabetes, cardiomyopathy, nephropathy, neuropathy, arthritis, etc. [80][81][82][83][84] Nitrite is hallmark of endogenous nitric oxide production, and their levels serve as the gold standard reflecting the increased oxidative stress resulting in cellular dysfunction. [85][86][87] It has been documented that administration of the substance with NO scavenging or NOS (nitric oxide synthase) inhibitory potential prevented EG-induced toxicity via inhibition of renal microvascular constriction to improve hemodynamic abnormality.…”

Section: Discussionmentioning

confidence: 99%

l-Arginine attenuates the ethylene glycol induced urolithiasis in ininephrectomized hypertensive rats: role of KIM-1, NGAL, and NOs

2015

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Background: Ethylene glycol (EG) exposure caused formation of calcium oxalate crystal that led to renal failure, which is associated with higher prevalence of hypertension. L-Arginine is known to have an antioxidant and nephro-protective potential. Objective: To evaluate the effect of L-arginine against EG-induced urolithiasis in uninephrectomized hypertensive rats. Material and methods: Uninephrectomized male Wistar rats (180-200 g) were used to induce urinary calculi through oral administration of EG (0.75%) in distilled water. Rats were treated with either distilled water (10 mg/kg, p.o.) or telmisartan (10 mg/kg, p.o.) or Cystone (500 mg/kg, p.o.) or L-arginine (250, 500, and 1000 mg/kg, p.o.) for 28 days. Various hemodynamic, biochemical, molecular, and histological parameters were assessed in kidney and heart. Results: Rats treated with L-arginine (500 and 1000 mg/kg) significantly restored altered relative organ weight, urine output, urine density, urinary pH, and water intake. EG-induced alterations in electrocardiographic (QRS interval, HR, and ST height) and hemodynamic (SBP, DBP, MABP, and LVEDP) abnormalities were significantly restored by L-arginine (500 and 1000 mg/kg) treatment. It also significantly restored alteration in serum and urine biochemical parameters induced by EG. The elevated oxido-nitrosative stress was also significantly decreased by L-arginine (500 and 1000 mg/kg) treatment. It also significantly down-regulated EG-induced up-regulated renal KIM-1, NGAL, eNOS, and iNOs mRNA expressions. Histological aberrations induced in the renal and cardiac tissues were also ameliorated by L-arginine treatment. Conclusion: L-Arginine exerts its nephro-and cardio-protective potential in EG-induced urolithiasis in uninephrectomized hypertensive rats via modulation of KIM-1, NGAL, eNOS, and iNOs mRNA expression.

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“…SOD is a primary enzyme since it is involved in the direct elimination of reactive oxygen species [55,56]. Reduced activity of SOD in the myocardial cells observed in cardiotoxicity may pose deleterious effects as the result of the accumulation of superoxide anion radicals and hydrogen peroxide [57,58].…”

Section: Discussionmentioning

confidence: 99%

Omega-3-fatty acid adds to the protective effect of flax lignan concentrate in pressure overload-induced myocardial hypertrophy in rats via modulation of oxidative stress and apoptosis

Ghule

Kandhare

Jadhav

et al. 2015

International Immunopharmacology

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Therapeutic effect of H. pylori nosode, a homeopathic preparation in healing of chronic H. pylori infected ulcers in laboratory animals

Cited by 36 publications

References 31 publications

Flax lignan concentrate reverses alterations in blood pressure, left ventricular functions, lipid profile and antioxidant status in DOCA-salt induced renal hypertension in rats

Flax lignan concentrate reverses alterations in blood pressure, left ventricular functions, lipid profile and antioxidant status in DOCA-salt induced renal hypertension in rats

l-Arginine attenuates the ethylene glycol induced urolithiasis in ininephrectomized hypertensive rats: role of KIM-1, NGAL, and NOs

Omega-3-fatty acid adds to the protective effect of flax lignan concentrate in pressure overload-induced myocardial hypertrophy in rats via modulation of oxidative stress and apoptosis

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