Therapeutic effects of bone marrow mesenchymal stem cells‐derived exosomes on osteoarthritis

Jin, Yi; Xu, Min; Zhu, Hai; Dong, Chen; Ji, Juan; Liu, Yake; Deng, Aidong; Gu, Zhifeng

doi:10.1111/jcmm.16860

Cited by 85 publications

(47 citation statements)

References 42 publications

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“…The authors also discovered that human umbilical cord Wharton’s jelly MSC-exos promoted macrophage polarization towards the M2 phenotype. Jin et al [ 77 ] demonstrated that BM–MSC-exosomes could keep chondrocytes alive by increasing COLII synthesis and inhibiting IL-1-induced senescence and apoptosis. Table 2 presents the chondrogenic markers related to exosome studies.…”

Section: Application Of 3d Spheroid Culture System To Chondrogenic Di...mentioning

confidence: 99%

3D Spheroid Cultures of Stem Cells and Exosome Applications for Cartilage Repair

Lee

2022

Life

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Cartilage is a connective tissue that constitutes the structure of the body and consists of chondrocytes that produce considerable collagenous extracellular matrix and plentiful ground substances, such as proteoglycan and elastin fibers. Self-repair is difficult when the cartilage is damaged because of insufficient blood supply, low cellularity, and limited progenitor cell numbers. Therefore, three-dimensional (3D) culture systems, including pellet culture, hanging droplets, liquid overlays, self-injury, and spinner culture, have attracted attention. In particular, 3D spheroid culture strategies can enhance the yield of exosome production of mesenchymal stem cells (MSCs) when compared to two-dimensional culture, and can improve cellular restorative function by enhancing the paracrine effects of MSCs. Exosomes are membrane-bound extracellular vesicles, which are intercellular communication systems that carry RNAs and proteins. Information transfer affects the phenotype of recipient cells. MSC-derived exosomes can facilitate cartilage repair by promoting chondrogenic differentiation and proliferation. In this article, we reviewed recent major advances in the application of 3D culture techniques, cartilage regeneration with stem cells using 3D spheroid culture system, the effect of exosomes on chondrogenic differentiation, and chondrogenic-specific markers related to stem cell derived exosomes. Furthermore, the utilization of MSC-derived exosomes to enhance chondrogenic differentiation for osteoarthritis is discussed. If more mechanistic studies at the molecular level are conducted, MSC-spheroid-derived exosomes will supply a better therapeutic option to improve osteoarthritis.

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Section: Application Of 3d Spheroid Culture System To Chondrogenic Di...mentioning

confidence: 99%

3D Spheroid Cultures of Stem Cells and Exosome Applications for Cartilage Repair

Lee

2022

Life

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“…He et al (2020) treated OA rats with BMSC-EVs, and the results indicated that BMSC-EVs improved chondrocyte phenotype and alleviated pain via ameliorating function of dorsal root ganglion (DRG). Moreover, BMSC-EVs were reported to regulate inflammation through restraining NF-κB pathway , controlling inflammation related factor Autotaxin-YAP , modulating macrophagocyte polarization (Zhang et al, 2020), and prevent chondrocyte apoptosis (Chen et al, 2020;Jin et al, 2021). Frontiers in Bioengineering and Biotechnology frontiersin.org…”

Section: The Therapeutic Role Of Different Mscderived Extracellular V...mentioning

confidence: 99%

“…The ability of MSC-EVs in converting ATP into pro-survival kinases make them potential in promoting cell proliferation for cartilage repair. Additionally, MSC-EVs are capable to inhibit apoptosis via mTOR pathway Jin et al, 2021;Lu et al, 2021;Zhou et al, 2022), and promote autophagy (Zhang and Jin, 2022) to improve cell performance of chondrocytes.…”

Section: Modulating Cell Fate Of Chondrocytementioning

confidence: 99%

The potential therapeutic role of extracellular vesicles in osteoarthritis

Jiang

Yuan

et al. 2022

Front. Bioeng. Biotechnol.

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Osteoarthritis (OA) is a worldwide and disabling disease, which cause severe pain and heavy socioeconomic burden. However, pharmacologic or surgical therapies cannot mitigate OA progression. Mesenchymal stem cells (MSCs) therapy has emerged as potential approach for OA treatment, while the immunogenicity and ethical audit of cell therapy are unavoidable. Compared with stem cell strategy, EVs induce less immunological rejection, and they are more stable for storage and in vivo application. MSC-EVs-based therapy possesses great potential in regulating inflammation and promoting cartilage matrix reconstruction in OA treatment. To enhance the therapeutic effect, delivery efficiency, tissue specificity and safety, EVs can be engineered via different modification strategies. Here, the application of MSC-EVs in OA treatment and the potential underlying mechanism were summarized. Moreover, EV modification strategies including indirect MSC modification and direct EV modification were reviewed.

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“…Exosomes derived from MSCs can inhibit early OA-induced cartilage damage by significantly inhibiting the expression of inflammatory genes, especially IL-1β (100,101). However, the repair mechanism of EVs or exosomes derived from MSCs on cartilage damage is not fully understood, and more research is needed in the future Another experiment demonstrated that BM-MSCs-exosomes could promote cartilage damage repair by promoting COL II synthesis and inhibiting catabolic markers including ADAMTS5 and MMP-13, while inhibiting IL-1β-induced senescence and apoptosis (102).…”

Section: Regeneration and Repair Signaling Mechanism Of Mscs In Damag...mentioning

confidence: 99%

Treatment and application of stem cells from different sources for cartilage injury: a literature review

Wang¹,

Zhang

Meng³

et al. 2022

Ann Transl Med

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Background and Objective: Cartilage defects and degeneration have a major impact on daily mobility and quality of life for millions of people worldwide. As the most effective seed cells for tissue engineering applications in regenerative medicine, mesenchymal stem cells (MSCs) are pluripotent cells with mesoderm and neural crest origin. The combination of biomaterial scaffolds with stem cells and drugs for cartilage damage repair has brought much hope to the medical field.Methods: We searched and compared the literature on cartilage damage repaired by stem cells through PubMed and Web of Science method, this review summarizes the research progress of mesenchymal stem cells from various tissue sources in repairing articular cartilage injury.

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Therapeutic effects of bone marrow mesenchymal stem cells‐derived exosomes on osteoarthritis

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 85 publications

References 42 publications

3D Spheroid Cultures of Stem Cells and Exosome Applications for Cartilage Repair

3D Spheroid Cultures of Stem Cells and Exosome Applications for Cartilage Repair

The potential therapeutic role of extracellular vesicles in osteoarthritis

Treatment and application of stem cells from different sources for cartilage injury: a literature review

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