Therapeutic efficacy of Albendazole and Mefloquine alone or in combination against early and late stages of Trichinella spiralis infection in mice

Abstract

Summary This study aimed to determine the effectiveness of mefl oquine alone or combined with albendazole in reduced doses against T. spiralis infection. One hundred and twenty albino mice were orally infected with 200 T. spiralis larvae/mouse. Drugs were administered during the enteral phase on days 1 to 3 and on the chronic phase on days 35 to 37 post-infection, and mice were sacrificed, respectively, at days 7 or 48 post-infection to count mature intestinal worms or encysted muscle larvae. The effect of the treatment on the histology of the target organs of each phase, intestine and diaphragm, was also evaluated. A signifi cant decrease in intestinal worms was found in all treated groups relative to the untreated control group at a peak of 93.7% in the combination albendazole-mefl oquine group. Results in all treated groups demonstrated a signifi cant decrease in muscle larvae relative to untreated control groups, achieving 86.2 % in the combined albendazole-mefl oquine group. There was a marked improvement in the intestinal and muscular architecture in all treated groups compared to the non-treated control group. Notably, the albendazole-mefl oquine group showed an almost complete recovery. The combined albendazole-mefl oquine low dose regimen had the highest effect on reducing parasite burden and restoring normal histological architecture.

Antihelminthic and antiangiogenic effects of zinc oxide nanoparticles on intestinal and muscular phases of trichinellosis

“…The albendazole effect was higher on T. spiralis adults than its effect on encapsulated larvae, with a percentage reduction of 99% and 68%, respectively. Similar results were obtained by Nada et al (2018) and Fahmy and Diab (2021), who detected more efficiency of albendazole against enteral stages of T. spiralis than parenteral ones. As noted, T. spiralis would become less vulnerable to albendazole when an infection becomes chronic, and its effectiveness against encapsulated muscle larvae is significantly diminished (Shalaby et al .…”

Potential therapeutic effect of platelet-rich plasma and albendazole on the muscular phase of experimental Trichinella spiralis infection

“…Therapeutic agents were administered 35 days post-inoculation during the chronic phase of the infection, according to Fahmy and Diab (2021) . The time of inoculation and therapeutic agent administration are shown in Table 1 .…”

Effect of Thymol Extract on Trichinellosis Compared to Albendazole Among Experimentally Infected Mice

“…Also, outbreaks were reported in other Mediterranean Countries, such as Greece, Italy, and Spain, during the few last years (Turiac et al, 2017). Trichinellosis belongs to encapsulated parasites and causes most human infections and deaths (Farid et al, 2019).…”