Therapeutic efficacy of long‐pulsed 755‐nm alexandrite laser for seborrheic keratoses

Abstract

The delivery of long-pulsed, high fluence laser energy to seborrheic keratoses with protection of the epidermis by an integrated dynamic cooling device is an effective treatment with low risk of side-effects, even in light-coloured lesions with few target pigments.

Sequential delivery of long‐pulsed 755‐nm alexandrite laser and long‐pulsed 1,064‐nm neodymium:yttrium‐aluminum‐garnet laser treatment for pigmented disorders

“…Accordingly, the use of a LP 755‐nm Alex laser would, theoretically, disintegrate tattoo particles more effectively and produce less vacuolar reactions to the surrounding tissues, compared to a LP 1064‐nm Nd:YAG laser. However, lightly pigmented lesions or deeply located lesions would require additional sessions of LP Alex laser treatment or combined treatment with ablative lasers . Thus, we presumed that a combined treatment with LP 755‐nm and LP 1064‐nm laser pulses would generate greater photoacoustic and photothermal effects on target pigment particles and surrounding tissue components, compared to treatment with a LP 755‐nm laser alone or a LP 1064‐nm laser alone.…”

“…However, high risks of recurrence and side effects, including prolonged post‐treatment erythema, post‐inflammatory hyperpigmentation, and hypertrophic or atrophic scarring, limit the use of ablative lasers, particularly in Asian patients with large pigmented nevus lesions. For these, non‐ablative long‐pulsed (LP) lasers at pulse durations of 1‐300 ms have been suggested as additional or alternative treatment modalities to theoretically destroy nests of nevi cells by selectively targeting pigment chromophores …”

“…Long‐pulsed lasers, including LP 532‐nm neodymium (Nd):YAG, LP 695‐nm ruby, and LP 755‐nm alexandrite (Alex) lasers, exhibit the advantages of high efficacy and a lower risk of side effects with short procedure times . The following parameters for LP 532‐nm Nd:YAG lasers for treating small acquired melanocytic nevi have been suggested a pulse duration of 20 ms, a spot size of 2 mm, and a fluence of 30‐50 J/cm 2 .…”

“…the advantages of high efficacy and a lower risk of side effects with short procedure times. 1,5 The following parameters for LP 532-nm Nd:YAG lasers for treating small acquired melanocytic nevi have been suggested a pulse duration of 20 ms, a spot size of 2 mm, and a fluence of 30-50 J/cm 2 . 1 Meanwhile, LP 755-nm Alex lasers have been used at a pulse duration of 3 ms, a spot size of 5-6 mm, and a fluence of 30-35 J/cm 2 .…”

Combination Treatments of 755 nm Alexandrite Laser with 1,064 nm Nd:YAG Laser Toning for Café Au Lait Macule

“…The 755 nm alexandrite laser has been widely used for CALM, due to it selectively destroys developed melanosomes with minimal injury to surrounding cellular structures. 4,5 And furthermore, the 1,064 nm Nd:YAG laser toning is proposed to cause the fragmentation of melanin granules and reduce the number of melanosomes without cellular destruction with a sub-photo-thermolytic fluence. 6 Recently, it has produced favorable outcomes, showing 50% to 74% response rates in many benign pigmented disorders, such as melasma and nevus of Ota.…”