Therapeutic Mechanism and Effect of Camptothecin on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice

Wang, Yizhuo; Liu, Kunjian; Zhou, Qi; Chen, Tong; Yu, Wei; Jiang, Yang; Li, Guofeng; Xiao, Huijie

doi:10.1155/2021/5556659

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…67 CPT inhibits the expressions of proinflammatory cytokines and improves ulcerative colitis induced by dextran sodium sulfate in terms of colon length and the disease activity index in rats. 68 In our experiment, we found that SCI induced downregulation of protein and mRNA expressions of Top-1, which may be result from SCI that rapidly leads to a large number of nerve cell death and immune microenvironment in early stage that inhibits cell proliferation and DNA replication in mice. Moreover, primary cultured neurons are difficult to proliferate, and OGD leads to obvious damage and death of primary cultured neurons.…”

Section: Discussionmentioning

confidence: 61%

“…CPT–bile acid conjugate alleviated sepsis‐induced liver injury by suppressing the NF‐κB signaling pathway 67 . CPT inhibits the expressions of proinflammatory cytokines and improves ulcerative colitis induced by dextran sodium sulfate in terms of colon length and the disease activity index in rats 68 . In our experiment, we found that SCI induced downregulation of protein and mRNA expressions of Top‐1, which may be result from SCI that rapidly leads to a large number of nerve cell death and immune microenvironment in early stage that inhibits cell proliferation and DNA replication in mice.…”

Section: Discussionmentioning

confidence: 99%

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Topoisomerase 1 inhibition modulates pyroptosis to improve recovery after spinal cord injury

Jiang

Ding

et al. 2022

The FASEB Journal

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Excessive neuroinflammation and neuronal loss contribute to mechanisms of spinal cord injury (SCI). Accumulating evidence has suggested that topoisomerase 1 (Top1) inhibition can suppress exacerbated immune responses and protect against lethal inflammation. Pyroptosis is a recently identified pro‐inflammatory programmed mode of cell death. However, the effects and underlying mechanisms of Top1 inhibition in SCI remains unclear. Locomotor functional recovery in mice was evaluated through Basso Mouse Scale (BMS). Neuronal loss was evaluated by immunochemistry staining of NeuN. Pyroptosis was determined by immunofluorescence staining, western blot, flow cytometry, cell viability, and cytotoxicity assays. In the present study, we estimated the effects of chemical inhibition of Top1 in an SCI model. Administration of Top1 inhibitor camptothecin (CPT) to mice significantly improved locomotor functional recovery after SCI. Moreover, CPT reduced Top1 level, inhibited nucleotide‐binding oligomerization domain‐like receptor 3 (NLRP3) inflammasome activation and pyroptosis, attenuated proinflammatory cytokines levels, diminished the number of neutrophil and neuronal loss in mice. Furthermore, CPT in oxygen‐glucose deprivation neurons down‐regulated Top1 level, attenuated NLRP3 inflammasome activation, and suppressed pyroptosis and inflammatory response. Together, our findings indicate that inhibition of Top1 with CPT can inhibit pyroptosis, control neuroinflammation, and improve functional recovery after SCI.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Topoisomerase 1 inhibition modulates pyroptosis to improve recovery after spinal cord injury

Jiang

Ding

et al. 2022

The FASEB Journal

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“…They can inhibit the expression of various cytokines, such as tumor necrosis factor (TNF)-α, IL-1β, IL-4, IL-6, IL-8, IL-12, IL-18, IL-22, and inducible nitric oxide synthase (iNOS) ( Zhao HM. et al, 2017 ; Li Y. et al, 2017 ; Zhao L. et al, 2017 ; Wang Y. et al, 2017 ; Huang et al, 2017 ; Sun et al, 2018 ; Wu et al, 2018 ; Lian et al, 2019 ; Ni et al, 2019 ; Yin et al, 2019 ; Liu et al, 2020 ; Wang Y. Z. et al, 2021 ; Yu et al, 2021 ).…”

Section: The Pathogenesis Of Ibdmentioning

confidence: 99%

Traditional Chinese Medicine and Natural Products: Potential Approaches for Inflammatory Bowel Disease

Yuan

et al. 2022

Front. Pharmacol.

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Inflammatory bowel disease (IBD) is a rare, recurrent, and intractable inflammation obstruction of the stomach tract, usually accompanied by inflammation of cell proliferation and inflammation of the colon and carries a particular cause of inflammation. The clinical use of drugs in western countries affects IBD treatment, but various adverse effects and high prices limit their application. For these reasons, Traditional Chinese Medicine (TCM) is more advantageous in treating IBD. This paper reviews the mechanism and research status of TCM and natural products in IBD treatment by analyzing the relevant literature to provide a scientific and theoretical basis for IBD treatment.

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“…Camptothecin, a quinoline alkaloid extracted from camptotheca acuminata , was also found to have therapeutic effects in mice with experimental IBD. Camptothecin may improve the expression of cellular inflammatory factors in mice with IBD by modulating clinical symptoms in IBD mice by modulating the expression of cellular inflammatory factors [ 210 ]. A recent review illustrated the great therapeutic potential of alkaloids of natural origin for UC [ 19 ].…”

Section: Nps With Ibd Therapeutic Activitymentioning

confidence: 99%

Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments

2023

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Inflammatory bowel disease (IBD) is a chronic, non-specific inflammatory disease of the intestine that can be classified as ulcerative colitis (UC) and Crohn’s disease (CD). Currently, the incidence of IBD is still increasing in developing countries. However, current treatments for IBD have limitations and do not fully meet the needs of patients. There is a growing demand for new, safe, and highly effective alternative drugs for IBD patients. Natural products (NPs) are used in drug development and disease treatment because of their broad biological activity, low toxicity, and low side effects. Numerous studies have shown that some NPs have strong therapeutic effects on IBD. In this paper, we first reviewed the pathogenesis of IBD as well as current therapeutic approaches and drugs. Further, we summarized the therapeutic effects of 170 different sources of NPs on IBD and generalized their modes of action and therapeutic effects. Finally, we analyzed the potential mechanisms of NPs for the treatment of IBD. The aim of our review is to provide a systematic and credible summary, thus supporting the research on NPs for the treatment of IBD and providing a theoretical basis for the development and application of NPs in drugs and functional foods.

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Therapeutic Mechanism and Effect of Camptothecin on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice

Cited by 8 publications

References 24 publications

Topoisomerase 1 inhibition modulates pyroptosis to improve recovery after spinal cord injury

Topoisomerase 1 inhibition modulates pyroptosis to improve recovery after spinal cord injury

Traditional Chinese Medicine and Natural Products: Potential Approaches for Inflammatory Bowel Disease

Treatment Effects of Natural Products on Inflammatory Bowel Disease In Vivo and Their Mechanisms: Based on Animal Experiments

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