Therapeutic potential and pharmacological activities of β‐eudesmol

Acharya, Bishwanath; Chai่jaroenkul, Wanna; Na‐Bangchang, Kesara

doi:10.1111/cbdd.13823

Cited by 42 publications

(25 citation statements)

References 55 publications

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“…Eudesmol possesses multiple positive bioactivities such as antiangiogenic, anticancer, anti-inflammatory activities which might therefore have played a role in the health improvement of diabetic and/or aflatoxicated rats fed BM. 44 LDH is a crucial enzyme in the anaerobic metabolic pathway which catalyzes the conversion of lactate to pyruvate-reducing NADþ to NADH. 45 LDH overexpression in some forms of type 2 diabetes hinders normal glucose metabolism and insulin secretion from beta-cells in islets of Langerhans leading to insulin secretory defects.…”

Section: Discussionmentioning

confidence: 99%

Barley microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis in rats

Mohamed¹,

Abdel-Rahim

Aly³

et al. 2021

Exp Biol Med (Maywood)

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Increased environmental pollution and unhealthy lifestyle are blamed for escalated chronic diseases. Exposure to aflatoxins was recently suggested to have a role in the increased incidence of type 2 diabetes mellitus. Diet modification and consumption of different functional food are now gaining attention, especially in diabetes management. This study investigates the effect of a diet containing barley microgreen against diabetes induced by streptozotocin with or without aflatoxin administration in rats. Barley microgreen was rich in 3′-Benzyloxy-5,6,7,4′-tetramethoxyflavone (48.8% of total) followed by 5β,7βH,10α-Eudesm-11-en-1α-ol (18.46%). Streptozotocin injection and/or aflatoxin administration significantly elevated glucose level, decreased insulin level, decreased β-cell function, deteriorated liver and kidney function parameters, and induced oxidative stress in the liver. Histopathology revealed irregular small-sized islets and decreased area % of insulin-positive beta cells in the pancreas, hepatic degeneration, nephropathy, and neuropathy in diabetic and/or aflatoxin administered rats compared to control. Barley microgreen diet fed to diabetic rats with or without aflatoxin alleviated all evaluated parameters. Barley microgreen diet also ameliorated the toxic effect of aflatoxin. In conclusion, exposure to aflatoxin aggravated diabetes and its complication. The incorporation of barley microgreen in the diet was able to control type 2 diabetes mellitus and the improved outcomes observed with barley microgreen treatments involved or occurred in conjunction with improved biomarkers of oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Barley microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis in rats

Mohamed¹,

Abdel-Rahim

Aly³

et al. 2021

Exp Biol Med (Maywood)

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“…However, Honokiol and Magnolol were verified as two major active components in MC using high pressure liquid chromatography (HPLC, approximately 0.8% and 2.1% in MC respectively), and related literature confirmed that they showed protective effects in an experimental sarcopenia animal model [ 9 ]. In addition, beta-Eudesmol is one of the most studied and major bioactive sesquiterpenes, showed therapeutic potential and pharmacological activities in a series of diseases [ 33 ]. Therefore, they were also included although they did not meet the ADME criteria.…”

Section: Resultsmentioning

confidence: 99%

“…The main active components were then filtered according to the optimal toxicokinetic ADME rules [oral bioavailability (OB) ≥ 30%, drug-like (DL) ≥ 0.18] [ 32 ]. If the component did not meet the filtering criteria, they were included if they were reported as effective against sarcopenia in relevant literatures [ 9 , 33 ]. The molecular structure of components was obtained from the PubChem ( https://pubchem.ncbi.nlm.nih.gov/ ) or Pharmgkb ( https://www.pharmgkb.org/ ).…”

Section: Methodsmentioning

confidence: 99%

Mechanisms of magnoliae cortex on treating sarcopenia explored by GEO gene sequencing data combined with network pharmacology and molecular docking

et al. 2022

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Background Administration of Magnoliae Cortex (MC) could induce remission of cisplatin-induced sarcopenia in mice, however, whether it is effective on sarcopenia patients and the underlying mechanisms remain unclear. Methods Sarcopenia related differentially expressed genes were analysed based on three Gene Expression Omnibus (GEO) transcriptome profiling datasets, which was merged and de duplicated with disease databases to obtain sarcopenia related pathogenic genes. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were than performed to analyse the role of proteins encoded by sarcopenia related pathogenic genes and the signal regulatory pathways involved in. The main active components and target proteins of MC were obtained by searching traditional Chinese medicine network databases (TCMSP and BATMAN-TCM). MC and sarcopenia related pathogenic genes shared target proteins were identified by matching the two. A protein–protein interaction network was constructed subsequently, and the core proteins were filtered according to the topological structure. GO and KEGG analysis were performed again to analyse the key target proteins and pathways of MC in the treatment of sarcopenia, and build the herbs-components-targets network, as well as core targets-signal pathways network. Molecular docking technology was used to verify the main compounds-targets. Results Sarcopenia related gene products primarily involve in aging and inflammation related signal pathways. Seven main active components (Anonaine, Eucalyptol, Neohesperidin, Obovatol, Honokiol, Magnolol, and beta-Eudesmol) and 26 target proteins of MC-sarcopenia, of which 4 were core proteins (AKT1, EGFR, INS, and PIK3CA), were identified. The therapeutic effect of MC on sarcopenia may associate with PI3K-Akt signaling pathway, EGFR tyrosine kinase inhibitor resistance, longevity regulating pathway, and other cellular and innate immune signaling pathways. Conclusion MC contains potential anti-sarcopenia active compounds. These compounds play a role by regulating the proteins implicated in regulating aging and inflammation related signaling pathways, which are crucial in pathogenesis of sarcopenia. Our study provides new insights into the development of a natural therapy for the prevention and treatment of sarcopenia.

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“…α-Eudesmol and β-eudesmol, two major SO compounds, showed higher values in white flower buds (2.04% and 3.66%, respectively) than in violet flower buds (0.43% and 0.91%, respectively). Previous studies have demonstrated that β-eudesmol has diverse pharmacological activities, such as anticancer and anti-inflammatory effects, as well as effects on the nervous system [ 27 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

Profiles of Essential Oils and Correlations with Phenolic Acids and Primary Metabolites in Flower Buds of Magnolia heptapeta and Magnolia denudata var. purpurascens

Hyeon

Hyun

et al. 2021

Molecules

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Magnolia flower buds are a source of herbal medicines with various active compounds. In this study, differences in the distribution and abundance of major essential oils, phenolic acids, and primary metabolites between white flower buds of Magnolia heptapeta and violet flower buds of Magnolia denudata var. purpurascens were characterised. A multivariate analysis revealed clear separation between the white and violet flower buds with respect to primary and secondary metabolites closely related to metabolic systems. White flower buds contained large amounts of monoterpene hydrocarbons (MH), phenolic acids, aromatic amino acids, and monosaccharides, related to the production of isoprenes, as MH precursors, and the activity of MH synthase. However, concentrations of β-myrcene, a major MH compound, were higher in violet flower buds than in white flower buds, possibly due to higher threonine levels and low acidic conditions induced by comparatively low levels of some organic acids. Moreover, levels of stress-related metabolites, such as oxygenated monoterpenes, proline, and glutamic acid, were higher in violet flower buds than in white flower buds. Our results support the feasibility of metabolic profiling for the identification of phytochemical differences and improve our understanding of the correlated biological pathways for primary and secondary metabolites.

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Therapeutic potential and pharmacological activities of β‐eudesmol

Cited by 42 publications

References 55 publications

Barley microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis in rats

Barley microgreen incorporation in diet-controlled diabetes and counteracted aflatoxicosis in rats

Mechanisms of magnoliae cortex on treating sarcopenia explored by GEO gene sequencing data combined with network pharmacology and molecular docking

Profiles of Essential Oils and Correlations with Phenolic Acids and Primary Metabolites in Flower Buds of Magnolia heptapeta and Magnolia denudata var. purpurascens

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