Therapeutic Potential of Plantamajoside

Goyal, Ahsas; Kushwah, Prashant Singh; Agrawal, Neetu

doi:10.1007/s43450-022-00252-y

Cited by 4 publications

(4 citation statements)

References 66 publications

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“…Natural compounds can be extracted using DESs through various methods, including assistance by ultrasound or microwaves or subcritical extraction techniques. These techniques are considered to be more effective than traditional stirring with heating because the plant cell walls can be more easily disrupted, which translates into a more efficient release of bioactive compounds. , It also decreases the time needed for extraction. ,, Unfortunately, microwave-assisted extraction can sometimes cause the degradation of sensitive metabolites. ,, …”

Section: Effect Of Type Of Des and Process Conditions For Extraction ...mentioning

confidence: 99%

“…269,270 It also decreases the time needed for extraction. 74,153,190 Unfortunately, microwaveassisted extraction can sometimes cause the degradation of sensitive metabolites. 194,271,272 Considering the influence of the temperature of extraction, most of the processes are performed in the range 40−70 °C.…”

Section: The Most Interesting Bioactive Compounds Extracted With Dess...mentioning

confidence: 99%

“…Phenolics such as chlorogenic acid, gallic acid, caffeic acid, and rosmarinic acid are secondary metabolites in plants . Because of their antioxidant and anti-inflammatory properties, they can be used as active ingredients in the cosmetic, food, and pharmaceutical industries. − Table presents the newest findings in the bioactivities and possible future applications of the chosen phenolic compounds extracted from plants. − Based on the information presented in Table , it is clear that current research focuses mostly on the medical application of phenolics in anticancer preparations. It is worth mentioning that phenolics have shown activities in the treatment of other civilization and neurodegenerative diseases.…”

Section: The Most Interesting Bioactive Compounds Extracted With Dess...mentioning

confidence: 99%

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The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

Wawoczny

Gillner

2023

J. Agric. Food Chem.

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There is growing interest in reducing the number of synthetic products or additives and replacing them with natural ones. The pharmaceutical, cosmetic, and food industries are especially focused on natural and bioactive chemicals isolated from plants or microorganisms. The main challenge here is to develop efficient and ecological methods for their isolation. According to the strategies and rules of sustainable development and green chemistry, green solvents and environmentally friendly technologies must be used. The application of deep eutectic solvents as efficient and biodegradable solvents seems to be a promising alternative to traditional methods. They are classified as being green and ecological but, most importantly, very efficient extraction media compared to organic solvents. The aim of this review is to present the recent findings on green extraction, as well as the biological activities and the possible applications of natural plant ingredients, namely, phenolics, flavonoids, terpenes, saponins, and some others. This paper thoroughly reviews modern, ecological, and efficient extraction methods with the use of deep eutectic solvents (DESs). The newest findings, as well as the factors influencing the efficiency of extraction, such as water content, and hydrogen bond donor and acceptor types, as well as the extraction systems, are also discussed. New solutions to the major problem of separating DESs from the extract and for solvent recycling are also presented.

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Section: Effect Of Type Of Des and Process Conditions For Extraction ...mentioning

confidence: 99%

Section: The Most Interesting Bioactive Compounds Extracted With Dess...mentioning

confidence: 99%

Section: The Most Interesting Bioactive Compounds Extracted With Dess...mentioning

confidence: 99%

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The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

Wawoczny

Gillner

2023

J. Agric. Food Chem.

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“…This phenylethanoid occurs mainly in the Plantaginaceae family (30 species) and particularly in the Plantago genus (20 species) [ 14 ]. It is a rarer and less-studied compound that exhibits multiple biological and pharmacological properties: Anti-inflammatory, diuretic, wound-healing, antiasthmatic, hepatoprotective, antiaging, antibiotic, antifungal, enzyme-inhibitory and neuroprotective, and anticancer [ 14 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Effect of Phenylethanoid Glycosides Isolated from Plantago lanceolata L.

Budzianowska

Totoń

Romaniuk-Drapała

et al. 2023

Life

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The aim of the study is to investigate whether the bioactive compounds isolated from P. lanceolata inflorescences, namely, phenylethanoid glucosides, acteoside, plantamajoside, and a flavonoid, isorhamnetin-3-O-rutinoside-4′-O-glucoside, possessed cytotoxic activity against the selected cancer cell lines. The potential antitumor effects of two phenylethanoid glycosides and one flavonoid were evaluated via MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on seven human carcinoma cell lines (MCF-7, MDA-MB-231, Caco-2, HepG2, OVCAR-3, U138-MG, U251-MG) and one nontumorigenic mammary epithelial cell line (MCF-12A). For the first time, acteoside was studied in ovarian cancer cell line OVCAR-3, and plantamajoside in all cell lines except breast adenocarcinoma MDA-MB-281 and hepatocarcinoma HepG2. The phenylethanoid glycosides showed stronger cytotoxic activity than that of the glycoside flavonoid. Acteoside and plantamajoside, at concentrations of 200 and 300 μM, respectively, had a highly toxic effect on the selected two cancer cell lines of breast adenocarcinoma MDA-MB-231 and MCF-7, ovarian cancer cell line OVCAR-3, glioblastoma cell line U138-MG, and hepatocarcinoma cell line HepG2. Both glycosides were significantly less cytotoxic towards nontumorigenic cell line MCF-12A; the effect appeared at a concentration of 400 μM. For the first time, the activity of acteoside and plantamajoside was compared in one parallel investigation. The results are discussed against a broad background of existing knowledge on biological effects, their mechanisms, and structure–activity relationships. Phenylethanoids may be potential compounds with cytotoxic activity against the selected cancer types.

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Anti-inflammatory effects and mechanism of Plantago asiatica L. and Lonicera japonica Thunb. extracts based on canine and feline kidney cell models

Liu,

Bai,

Wang

et al. 2025

Journal of Ethnopharmacology

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Therapeutic Potential of Plantamajoside

Cited by 4 publications

References 66 publications

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents

Cytotoxic Effect of Phenylethanoid Glycosides Isolated from Plantago lanceolata L.

Anti-inflammatory effects and mechanism of Plantago asiatica L. and Lonicera japonica Thunb. extracts based on canine and feline kidney cell models

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