2014
DOI: 10.1371/journal.pone.0086724
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Therapeutic Role of Ursolic Acid on Ameliorating Hepatic Steatosis and Improving Metabolic Disorders in High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Rats

Abstract: BackgroundNon-alcoholic fatty liver disease (NAFLD) is one of the most prevalent liver diseases around the world, and is closely associated with obesity, diabetes, and insulin resistance. Ursolic acid (UA), an ubiquitous triterpenoid with multifold biological roles, is distributed in various plants. This study was conducted to investigate the therapeutic effect and potential mechanisms of UA against hepatic steatosis in a high-fat diet (HFD)-induced obese non-alcoholic fatty liver disease (NAFLD) rat model.Met… Show more

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Cited by 126 publications
(107 citation statements)
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“…Fat accumulation in the liver plays a critical role in the initiation and progression of NAFLD [22].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Fat accumulation in the liver plays a critical role in the initiation and progression of NAFLD [22].…”
Section: Discussionmentioning
confidence: 99%
“…Many researchers studied the effect of high-fat diet (HFD), high-fructose diet (HFruD) and high-fructose high-fat diet (HFHF) on the liver [21,22,39]. The missing data are the comparison effect of these groups i.e.…”
Section: Introductionmentioning
confidence: 99%
“…According to previous reports [53,54,55], human liver cell line HL7702 and HepG2 were selected for NASH research and purchased from Shanghai Cell bank (Chinese Academy of Science, Shanghai, China), and cultured in DMEM with 25 mM glucose, 5 mM glutamine, 10% fetal bovine serum (FBS), 100 μg/mL penicillin and 100 μg/mL streptomycin at 37 °C under a 5% CO 2 environment. The cell concentrations were adjusted to 1 × 10 5 /mL and 200 μL was added to each cell in a 96-cell plate.…”
Section: Methodsmentioning
confidence: 99%
“…Ursolic acid (UA) is a pentacyclic triterpene natural compound found in the leaves, flowers and fruits of medicinal herbs such as Rosmarinus officinalis (rosemary), Ocimum basilicum (basil), Eriobotrya japonica (medlar), Eugenia jambolana (jamelão), Origanum vulgare (oregano) leaves, Eucalyptus globulus (eucalyptus) leaves and bark, Coffea arabica (coffee) leaves and Pyrus malus (apple peel) . Some of the proven biological effects of UA are anti‐inflammatory actions , antioxidant effects , anti‐carcinogenic effects , attenuation of muscle mass atrophy and muscle synthesis , thermogenesis activation and anti‐obesity effects . The main mechanisms of action of UA involve the following: the activation of uncoupling protein 1 (UCP1) and adenosine monophosphate ratio (AMP)‐activated protein kinase (AMPK) in adipose tissue, the reduction of the atrogin and muscle ring‐finger protein‐1 (MuRF1) in skeletal muscle, and a greater release of growth hormone and insulin‐like factor 1 (IGF‐1) into the bloodstream, as well as increased muscle protein kinase B (PKB/Akt) and mammalian target of rapamycin (mTOR).…”
Section: Introductionmentioning
confidence: 99%