Therapeutic Success of Vitamin D Replacement in Oral Pemphigus Vulgaris: a Case Report

Arantes, Diego Antônio Costa; Guimarães, Júlia Pitanga da Silva; Batista, Aline Carvalho

doi:10.1016/j.oooo.2018.02.085

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 Hanya satu laporan kasus yang melaporkan keberhasilan pemberian vitamin D pada PV oral memberikan remisi klinis lesi dan tidak ada relaps setelah 6 bulan follow-up. 8 Berdasarkan hasil pencarian jurnal, didapatkan satu artikel yang sesuai dengan pertanyaan klinis dan dilakukan telaah kritis. Penelitian Moravvej, dkk.…”

Section: Pertanyaan Klinisunclassified

Hubungan Defisiensi Vitamin D dengan Keparahan Pemfigus Vulgaris

Chandra

Oentari

2022

CDK

View full text Add to dashboard Cite

Latar Belakang: Pemfigus vulgaris (PV) merupakan penyakit bulosa autoimun kulit dan membran mukosa yang jarang, disebabkan oleh IgG-autoantibodi yang secara langsung menyerang desmoglein dan menyebabkan akantolisis. Rendahnya kadar vitamin D telah dikaitkan dengan keparahan penyakit pemfigus. Peran vitamin D pada perkembangan PV karena efek regulasi sistem imun dengan menekan fungsi sel Th1 dan menginduksi aktivitas sel Th2, sehingga meningkatkan sitokin yang berhubungan dengannya. Selain itu, vitamin D juga dapat meningkatkan populasi sel Treg yang berperan menekan sistem imun dan mencegah penyakit autoimun. Evidence-based case report ini bertujuan untuk mengetahui hubungan defisiensi vitamin D dengan keparahan penyakit PV. Metode: Penelusuran artikel dilakukan di Pubmed dan Cochrane berdasarkan pertanyaan klinis dan pemilihan artikel sesuai kriteria inklusi dan eksklusi. Artikel yang terpilih ditelaah kritis berdasarkan aspek validity, importance, dan applicability. Hasil: Didapatkan 1 artikel cross-sectional oleh Moravvej, et al, yang melaporkan defisiensi vitamin D berhubungan dengan PAAS kutaneus yang lebih tinggi (OR 1,36 (1,11-1,66); p<0,01) dan total PAAS kutaneus yang lebih tinggi (OR 1,24 (1,08-1,41); p<0,01). Studi ini dinyatakan sahih, penting, dan dapat diterapkan pada pasien kami. Simpulan: Defisiensi vitamin D berhubungan dengan keparahan PV. Background: Pemphigus vulgaris (PV) is a rare autoimmune bullous disease of the skin and mucous membranes, caused by IgG-autoantibodies that directly attack desmoglein, causing acantholysis. Low vitamin D level has been associated with PV’s severity. The role of vitamin D in the development of PV is due to its regulatory effect on the immune system by suppressing Th1-cells function and inducing Th2-cell activity, thereby increasing the associated cytokines. Vitamin D can also increase the population of Treg-cells that play a role in suppressing the immune system and preventing autoimmune diseases. This evidence-based case report aims to determine the relationship of vitamin D deficiency with the severity of PV. Method: Relevant articles were searched through Pubmed and Cochrane based on clinical questions and selected according to inclusion and exclusion criteria. Selected articles were analyzed critically based on validity, importance, and applicability. Results: One cross-sectional article by Moravvej, et al, reported vitamin D deficiency was associated with higher cutaneous PAAS (OR 1.36 (1.11-1.66); p<0.01) and total cutaneous PAAS (OR 1.24 (1.08-1.41); p<0.01). This study was valid, important, and applicable to our patients. Conclusion: Vitamin D deficiency is associated with the severity of PV.

show abstract

Section: Pertanyaan Klinisunclassified

Hubungan Defisiensi Vitamin D dengan Keparahan Pemfigus Vulgaris

Chandra

Oentari

2022

CDK

View full text Add to dashboard Cite

show abstract

Nutrition and bullous diseases

Stoj

2022

Clinics in Dermatology

View full text Add to dashboard Cite

Skin Barrier and Autoimmunity—Mechanisms and Novel Therapeutic Approaches for Autoimmune Blistering Diseases of the Skin

2019

View full text Add to dashboard Cite

One of the most important functions of the skin besides regulating internal body temperature includes formation of the barrier between the organism and the external environment, hence protecting against pathogen invasion, chemical and physical assaults and unregulated loss of water and solutes. Disruption of the protective barrier is observed clinically in blisters and erosions of the skin that form in autoimmune blistering diseases where the body produces autoantibodies against structural proteins of the epidermis or the epidermal-dermal junction. Although there is no cure for autoimmune skin blistering diseases, immune suppressive therapies currently available offer opportunities for disease management. In cases where no treatment is sought, these disorders can lead to life threatening complications and current research efforts have focused on developing therapies that target autoantibodies which contribute to disease symptoms. This review will outline the involvement of the skin barrier in main skin-specific autoimmune blistering diseases by describing the mechanisms underpinning skin autoimmunity and review current progress in development of novel therapeutic approaches targeting the underlying causes of autoimmune skin blistering diseases.

show abstract

Therapeutic Success of Vitamin D Replacement in Oral Pemphigus Vulgaris: a Case Report

Cited by 4 publications

References 0 publications

Hubungan Defisiensi Vitamin D dengan Keparahan Pemfigus Vulgaris

Hubungan Defisiensi Vitamin D dengan Keparahan Pemfigus Vulgaris

Nutrition and bullous diseases

Skin Barrier and Autoimmunity—Mechanisms and Novel Therapeutic Approaches for Autoimmune Blistering Diseases of the Skin

Contact Info

Product

Resources

About