Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits

Kim, Han-Sem; Lee, Jung Hwan; Mandakhbayar, Nandin; Jin, Guang‐Zhen; Kim, Sungjin; Yoon, Ji‐Young; Jo, Seung Bin; Park, Jeong-Hui; Singh, Rajendra K.; Jang, Jun‐Hyeog; Shin, Ueon Sang; Knowles, Jonathan C.

doi:10.1016/j.biomaterials.2021.120857

Cited by 25 publications

(12 citation statements)

References 64 publications

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“…S4). These innate hydrophilic properties of Chit and PM, as well as the highly nano-rough surface topological features of the nanocomposites, might influence the increased hydrophilicity [ 26 ]. The nanocomposites also exhibited a level of water-uptake capacity, which allowed for the rapid appearance of adhesion and reactivity with humidity.…”

Section: Resultsmentioning

confidence: 99%

“…c AFM surface images of CNT@CPM, exhibiting a highly rough nanoto-pographical surface, d with a roughness ranged from 32.1 nm to 98.2 nm as the ratio of PM increased, and contact angles; hydrophilicity varies depending on concentration of PM. e XPS scanned revealing that the self-assembled CNT@CPM had clear shift of binding energy properties of Chit and PM, as well as the highly nanorough surface topological features of the nanocomposites, might influence the increased hydrophilicity [26]. The nanocomposites also exhibited a level of wateruptake capacity, which allowed for the rapid appearance of adhesion and reactivity with humidity.…”

Section: Resultsmentioning

confidence: 99%

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Wearable CNTs-based humidity sensors with high sensitivity and flexibility for real-time multiple respiratory monitoring

et al. 2022

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Sensors, such as optical, chemical, and electrical sensors, play an important role in our lives. While these sensors already have widespread applications, such as humidity sensors, most are generally incompatible with flexible/inactive substrates and rely on conventional hard materials and complex manufacturing processes. To overcome this, we develop a CNT-based, low-resistance, and flexible humidity sensor. The core–shell structured CNT@CPM is prepared with Chit and PAMAM to achieve reliability, accuracy, consistency, and durability, resulting in a highly sensitive humidity sensor. The average response/recovery time of optimized sensor is only less than 20 s, with high sensitivity, consistent responsiveness, good linearity according to humidity rates, and low hysteresis (− 0.29 to 0.30 %RH). Moreover, it is highly reliable for long-term (at least 1 month), repeated bending (over 15,000 times), and provides accurate humidity measurement results. We apply the sensor to smart-wear, such as masks, that could conduct multi-respiratory monitoring in real-time through automatic ventilation systems. Several multi-respiratory monitoring results demonstrate its high responsiveness (less than 1.2 s) and consistent performance, indicating highly desirable for healthcare monitoring. Finally, these automatic ventilation systems paired with flexible sensors and applied to smart-wear can not only provide comfort but also enable stable and accurate healthcare in all environments.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Wearable CNTs-based humidity sensors with high sensitivity and flexibility for real-time multiple respiratory monitoring

et al. 2022

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“…Only one (2% of total) article was sorted in this category [ 87 ], as the element of focus was a tri-molecule dexamethasone-FGF2-phenamil loading in a chitosan/bioglass-coated PCL scaffold. Silicon was associated to the coated bioglass on the PCL scaffold, and was one ingredient out of a vast association of doping agents.…”

Section: Resultsmentioning

confidence: 99%

In Vivo Application of Silica-Derived Inks for Bone Tissue Engineering: A 10-Year Systematic Review

et al. 2022

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As the need for efficient, sustainable, customizable, handy and affordable substitute materials for bone repair is critical, this systematic review aimed to assess the use and outcomes of silica-derived inks to promote in vivo bone regeneration. An algorithmic selection of articles was performed following the PRISMA guidelines and PICO method. After the initial selection, 51 articles were included. Silicon in ink formulations was mostly found to be in either the native material, but associated with a secondary role, or to be a crucial additive element used to dope an existing material. The inks and materials presented here were essentially extrusion-based 3D-printed (80%), and, overall, the most investigated animal model was the rabbit (65%) with a femoral defect (51%). Quality (ARRIVE 2.0) and risk of bias (SYRCLE) assessments outlined that although a large majority of ARRIVE items were “reported”, most risks of bias were left “unclear” due to a lack of precise information. Almost all studies, despite a broad range of strategies and formulations, reported their silica-derived material to improve bone regeneration. The rising number of publications over the past few years highlights Si as a leverage element for bone tissue engineering to closely consider in the future.

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“…The integrin family may play a crucial role in this interaction as the major cellular receptors responsible for sensing and manipulating the ECM with integrated topographical and biochemical signals [ 10 ]. Kim et al reported that a nHAP composited material with nano-roughened surface can accelerate the cellular responses through integrin-triggered focal adhesions [ 11 ]. The activation of integrin α5 has been shown to play a key role in osteogenesis [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Free or fixed state of nHAP differentially regulates hBMSC morphology and osteogenesis through the valve role of ITGA7

Bao

Liu

et al. 2022

Bioactive Materials

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Therapeutic tissue regenerative nanohybrids self-assembled from bioactive inorganic core / chitosan shell nanounits

Cited by 25 publications

References 64 publications

Wearable CNTs-based humidity sensors with high sensitivity and flexibility for real-time multiple respiratory monitoring

Wearable CNTs-based humidity sensors with high sensitivity and flexibility for real-time multiple respiratory monitoring

In Vivo Application of Silica-Derived Inks for Bone Tissue Engineering: A 10-Year Systematic Review

Free or fixed state of nHAP differentially regulates hBMSC morphology and osteogenesis through the valve role of ITGA7

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