There is no influence of a temperature rise on in vivo adsorption of UV filters into the stratum corneum

Clarys, Peter; Gabard, B.; Lambrecht, Renzo; Barel, Alain; Bieli, E.; Shi, Ludi

doi:10.1016/s0923-1811(01)00100-1

Cited by 14 publications

(8 citation statements)

References 10 publications

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“…13 Temperature can also play a role in absorption with UV filters, but the study by Clarys et al showed no such relation. 14 Other compounds such as dihydrotestosterone showed a positive relation between temperature and skin penetration. 15 Most of the BZ-3 excreted in urine was in the conjugated form; this is consistent with previous studies showing that BZ-3 undergoes extensive conjugation in the body.…”

Section: Discussionsupporting

confidence: 92%

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Percutaneous absorption of the sunscreen benzophenone-3 after repeated whole-body applications, with and without ultraviolet irradiation

Gonzalez

Farbrot

Larkö

et al. 2005

British Journal of Dermatology

149

107

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Section: Discussionsupporting

confidence: 92%

“…Temperature can also play a role in absorption with UV filters, but the study by Clarys et al . showed no such relation 14 . Other compounds such as dihydrotestosterone showed a positive relation between temperature and skin penetration 15 …”

Section: Discussionmentioning

confidence: 97%

Percutaneous absorption of the sunscreen benzophenone-3 after repeated whole-body applications, with and without ultraviolet irradiation

Gonzalez

Farbrot

Larkö

et al. 2005

British Journal of Dermatology

149

107

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show abstract

“…This was similar in patterns to our earlier results of oxybenzone with PDMS membrane (Gu et al, 2004). Clarys et al (2001) have found from an in vivo study in humans that temperature did not significantly alter the adsorption of sunscreens into stratum corneum. In vitro diffusion study might demonstrate slightly different permeation properties than in vivo experiment regarding temperature, as living skin exposed to high environmental temperature will increase blood circulation and sweating, which would consequently facilitate transport of medications from the absorption site.…”

Section: Resultssupporting

confidence: 92%

In Vitro Permeation Characterization of the Analgesic Ibuprofen and the Sunscreen Oxybenzone

Gu¹,

Dannefaer²,

Collins³

2008

Drug Development and Industrial Pharmacy

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Ibuprofen, one of the mostly prescribed nonsteroidal antiinflammatory drugs (NSAIDs), has been proposed as a topical medication for secondary prevention against skin damage induced by sunburn. The objective of this study was to characterize transmembrane permeation of ibuprofen and sunscreen oxybenzone across poly(dimethyl siloxane) (PDMS) membrane. In vitro diffusion studies were carried out at 37° and 45°C, using a series of ibuprofen and oxybenzone samples, either individually or in combination. Concentrations of ibuprofen and oxybenzone in the receptor compartment for up to 6 h were measured using a high-performance liquid chromatography (HPLC) assay. Ibuprofen and oxybenzone permeated across the PDMS membrane in all diffusion studies. When applied individually, permeation percentages of ibuprofen and oxybenzone ranged from 1.0 to 4.1% and from 13.2 to 25.8%, respectively. When applied in combination, permeation percentages of ibuprofen and oxybenzone were 0.3-1.4% and 7.8-24.3%, respectively. Transmembrane permeation was significantly suppressed when both compounds were present concurrently. High temperature promoted the diffusion process of oxybenzone; a linear correlation was also observed between oxybenzone concentration and its permeation. The proposed permeation enhancement between ibuprofen and oxybenzone was not observed from this study. The potential transdermal interaction and systemic absorption from concurrent application of topical analgesics and sunscreens thus requires further systematic evaluation.

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“…However, statistical analysis of the data between the two temperatures did not reveal statistically significant differences in the overall permeation percentage of DEET and oxybenzone. Clarys et al (2001) have recently concluded from an in-vivo human study that temperature does not significantly alter the adsorption of sunscreen into the stratum corneum. The study was conducted at 31 and 40¯C, and only the penetration patterns of sunscreen into the stratum corneum were measured through skin stripping.…”

Section: Discussionmentioning

confidence: 99%

In-vitro permeation of the Insect repellent N,N-diethyl-m-toluamide (DEET) and the sunscreen oxybenzone

Kasichayanula

Fediuk

et al. 2004

Journal of Pharmacy and Pharmacology

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The permeation behaviours of the insect repellent N,N-diethyl-m-toluamide (DEET) and the sunscreen oxybenzone were assessed in a series of in-vitro diffusion studies, using piglet skin and poly (dimethylsiloxane) (PDMS) membrane. The transmembrane permeability of DEET and oxybenzone across piglet skin and PDMS membrane was dependent on dissolving vehicles and test concentrations. An enhanced permeation increase across piglet skin was found for DEET and oxybenzone when both compounds were present in the same medium (DEET: 289% in propylene glycol, 243% in ethanol and 112% in poly(ethylene glycol) (PEG-400); oxybenzone: 139% in PEG-400, 120% in propylene glycol and 112% in ethanol). Permeation enhancement was also observed in PDMS membrane (DEET: 207% in ethanol, 124% in PEG-400 and 107% in propylene glycol; oxybenzone: 254% in PEG-400, 154% in ethanol and 105% in propylene glycol). PDMS membrane was found to be a suitable candidate for in-vitro diffusion evaluations. This study shows that the permeations of the insect repellent DEET and the sunscreen oxybenzone were synergistically enhanced when they were applied simultaneously.

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There is no influence of a temperature rise on in vivo adsorption of UV filters into the stratum corneum

Cited by 14 publications

References 10 publications

Percutaneous absorption of the sunscreen benzophenone-3 after repeated whole-body applications, with and without ultraviolet irradiation

Percutaneous absorption of the sunscreen benzophenone-3 after repeated whole-body applications, with and without ultraviolet irradiation

In Vitro Permeation Characterization of the Analgesic Ibuprofen and the Sunscreen Oxybenzone

In-vitro permeation of the Insect repellent N,N-diethyl-m-toluamide (DEET) and the sunscreen oxybenzone

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