Thermal and mechanical characteristics of poly(l-lactic acid) nanocomposite scaffold

Lee, Jong Hoon; Park, Tae Gwan; Park, Ho Sik; Lee, Sang Soo; Lee, Youngkwan; Yoon, Sung Chul; Nam, Jae‐Do

doi:10.1016/s0142-9612(03)00080-2

Cited by 259 publications

(153 citation statements)

References 27 publications

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“…It is inferred that if better interactions between the phase are achieved, an increase in T g could be expected due to the diminution of flexibility and motility of the polymer chains, their intermolecular interactions with the ORMOGLASS, and the steric effect applied by the ORMOGLASS. 45 It is thus believed that T g remained quasi-unchanged, not only because the fibers are a class-I hybrid material, but also because the phases are not homogeneously blended. Even though considered as not significant, the very slight decreases of T g observed after incorporation of the ORMOGLASS may suggest that the presence of the ORMOGLASS however affected T g to a very low extent.…”

mentioning

confidence: 99%

Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment

Sachot¹,

Roguska²,

Planell³

et al. 2017

IJN

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The success of scaffold implantation in acellular tissue engineering approaches relies on the ability of the material to interact properly with the biological environment. This behavior mainly depends on the design of the graft surface and, more precisely, on its capacity to biodegrade in a well-defined manner (nature of ions released, surface-to-volume ratio, dissolution profile of this release, rate of material resorption, and preservation of mechanical properties). The assessment of the biological behavior of temporary templates is therefore very important in tissue engineering, especially for composites, which usually exhibit complicated degradation behavior. Here, blended polylactic acid (PLA) calcium phosphate ORMOGLASS (organically modified glass) nanofibrous mats have been incubated up to 4 weeks in physiological simulated conditions, and their morphological, topographical, and chemical changes have been investigated. The results showed that a significant loss of inorganic phase occurred at the beginning of the immersion and the ORMOGLASS maintained a stable composition afterward throughout the degradation period. As a whole, the nanostructured scaffolds underwent fast and heterogeneous degradation. This study reveals that an angiogenic calcium-rich environment can be achieved through fast-degrading ORMOGLASS/PLA blended fibers, which seems to be an excellent alternative for guided bone regeneration.

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mentioning

confidence: 99%

Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment

Sachot¹,

Roguska²,

Planell³

et al. 2017

IJN

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“…This suggested that the incorporation of PLLA in higher quantities resulted in the increase in the crystallinity of the scaffolds. [29,30] The peak at 18.5° 2θ was present in all the scaffolds. The d-spacing, crystallite size (D), and lattice strain (Table 2) were calculated using the peak details at 18.5° 2θ.…”

Section: Mechanical Analysismentioning

confidence: 89%

Evaluation of poly(L-lactide) and chitosan composite scaffolds for cartilage tissue regeneration

Mallick

Pal

Rastogi

et al. 2016

Designed Monomers and Polymers

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The present study delineates the development of chitosan and poly(L-lactide) (PLLA) scaffolds cross-linked using a mixture of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), n-hydroxysuccinimide (NHS), and chondroitin sulfate (CS) for cartilage tissue engineering applications. Chitosan and PLLA were varied in concentration for developing scaffolds and prepared by freeze-drying method. The various scaffolds were studied using scanning electron microscopy (SEM), porosity by mercury intrusion porosimeter, and the molecular interactions among polymers using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) studies. Differential scanning calorimetry (DSC) was used to predict the thermal properties of the scaffolds. The mechanical properties of the scaffolds were studied using static mechanical tester. The ability of the scaffolds to support chondrocyte proliferation was also studied. The microscopy suggests that the pore size of the scaffolds varied with the composition in the range of 38-172 μm and the porosities in the range of 73-93%. The XRD and the FTIR studies suggested that an alternation in the composition of the scaffolds altered the molecular interactions among the scaffold components. An increase in the chitosan content enhanced the swelling property. The degradation of the scaffolds was least when the proportion of chitosan and PLLA was in the ratio of 70:30. The in vitro cell proliferation study suggested that the developed scaffolds were able to support chondrogenesis, the glycosaminoglycan (GAG) content of the mature chondrocyte was 40 μg/ml and the viability was approximately 90%. Hence, the so designed scaffolds may be tried for cartilage tissue engineering applications.

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“…It is well documented that the properties of porous BioPUs can be improved by introducing nanoparticles or nanoclay into the PU matrix. The addition of nanoparticles into the PU matrix can slow down a steep reduction in mechanical properties during biodegradation [223,224]. Thus, the moduli of PU nanocomposites increase from 3 to 7 MPa (133 %) and epoxy nanocomposites from 1.1 to 2.3 GPa (109 %) by the addition of 2-8 wt.…”

Section: Biopu-based Nanocompositesmentioning

confidence: 99%

“…It has been reported that the storage modulus of PLA/layered silicate nanocomposites is increased from 1.63 to 2.32 GPa (42 %), and the biodegradation rate of the obtained nanocomposite is significantly accelerated in comparison to pristine polymer in terms of the weight loss and molecular weight [227]. Also, incorporation of small amounts of MMT into PLLA can increase the mechanical stiffness of PLLA porous scaffolds [224]. However, the possible toxicity of nanoparticles and other nanocomponents including carbon nanotubes and metal nanoparticles (such as Ag and Au nanoparticles) should be mentioned [228,229].…”

Section: Biopu-based Nanocompositesmentioning

confidence: 99%

Synthesis and structure-property relationships of biodegradable polyurethanes

Pergal¹,

Blaban²

2017

Biodegradable Polymers: Recent Developments and New Perspectives

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Thermal and mechanical characteristics of poly(l-lactic acid) nanocomposite scaffold

Cited by 259 publications

References 27 publications

Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment

Fast-degrading PLA/ORMOGLASS fibrous composite scaffold leads to a calcium-rich angiogenic environment

Evaluation of poly(L-lactide) and chitosan composite scaffolds for cartilage tissue regeneration

Synthesis and structure-property relationships of biodegradable polyurethanes

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