Thermal compatibility between hydroquinone and retinoic acid in pharmaceutical formulations

Compatibility studies of hydrocortisone with excipients using thermogravimetric analysis supported by multivariate statistical analysis

“…A detailed examination of the shapes of TG traces and temperature ranges over which the stages of thermal decomposition occurred showed that the TG technique did not provide unequivocal data in the case of compatibility study between hydrocortisone and selected excipients. These findings are consistent with those of Mendonça et al [9], who studied compatibility/incompatibility in the mixtures of hydroquinone and retinoic acid with nine excipients. They confirmed that if no interactions occur, the TG trace of the mixture presents behaviour of both ingredients individually.…”

“…Thermogravimetry (TG) is one of the thermal methods that has been used to detect compatibilities of API and excipients [9]. This technique is commonly applied to the study of thermal decomposition providing information on thermal stability of pharmaceutical substances.…”

“…In the case of incompatibility study, TG allows a direct comparison of thermal profiles of API and excipients with those of their mixtures [9]. Unfortunately, these comparisons do not provide unequivocal data about compatibilities, because crucial information that can be extracted from the shape of TG traces is the change of mass (loss or gain) during thermal decomposition and the temperature range within which this process occurs.…”

Synthesis, characterization and thermal behavior of copper(II) complexes with pyridoxal thiosemi (PLTSC)- and S-methylisothiosemicarbazone (PLITSC)

“…The thermal analysis of compounds with potential biological activity is a common part in their characterization [3,4] as offers valuable, sometimes essential data to develop new pharmaceutical forms [5] or to detect structural changes or polymorphism [6] in materials used in drug formulation or in their quality control [7]. In addition, with increasing sensitivity of thermal equipments by means of thermal methods, important structural details could be determined [8] that are sometimes difficult to obtain by other techniques.…”

Pyrolysis of cyclo-aromatic diesters

“…This technique measures the mass loss as a function of temperature or time. It allows understanding the thermal degradation pathways and degradation kinetics of polymers, organic or inorganic compounds [1][2][3][4][5][6][7]. Also, it makes it possible to study the evaporation process, product and component stability, and changes in component properties during heating in inert or oxidative atmospheres, which is a necessary knowledge in order to find the practical applications of many compounds.…”