Thermal properties and degradation of enantiomeric copolyesteramides poly(lactic acid-co-alanine)s

“…Further, researchers started to study the effects of chemical structural distinctions of monomers (e.g., alloisomerism, residues or segmers) on the properties of PEAs. For example, the group of Yuichi Ohya has systematically studied enantiomeric poly(lactic acid- co -alanine)s based on poly( l -lactic acid- co - l -alanine)s and poly( d -lactic acid- co - d -alanine)s. − It has been first confirmed that different stereocomplexes could exhibit distinctive crystallization, thermal properties, and degradability, which would further influence their biological behaviors. Then, Yujiang Fan et al took the lead in trying stereoisomeric l - and d -Phe for the reaction of AA-PEAs and evaluated their enzymatic biodegradability.…”

Section: Structure–property Relationships Of Poly(ester Amide)smentioning

confidence: 99%

Recent Advances of Poly(ester amide)s-Based Biomaterials

Han

2022

Biomacromolecules

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Biodegradable and biocompatible biomaterials have offered much more opportunities from an engineering standpoint for treating diseases and maintaining health. Poly(ester amide)s (PEAs), as an outstanding family among such biomaterials, have risen overwhelmingly in the past decades. These synthetic polymers have easily and widely available raw materials and a diversity of synthetic approaches, which have attracted considerable attention. More importantly, combining the superiorities of polyamides and polyesters, PEAs have emerged with better functions. They could have improved biodegradability, biocompatibility, and cell− material interactions. The PEAs derived from α-amino acids even allow the introduction of pendant sites for further modification or functionalization. Meanwhile, it is gradually recognized that the chemical structures are closely related to the physiochemical and biological properties of PEAs so that their properties can be precisely controlled. PEAs therefore become significant materials in the biomedical fields. This review will attempt to summarize the recent progress in the development of PEAs with respect to the preparation materials and methods, structure−property relationships along with their latest biomedical accomplishments, especially for drug delivery and tissue engineering.

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“…There are some works reported in the literature on the use of AFM-IR [162][163][164][165][166] to examine the behavior of polymer crystallization and diffusion in complex systems including equimolar miscible and immiscible crystalline blends at the nanoscale level [161,162,[166][167][168]. Such studies used AFM-IR to analyze the crystallization behavior of an immiscible biopolyester based on polycaprolactone (PCL) and polyethylene glycol (PEG).…”

Section: Afm-ir In the Crystallization Of Immiscible Blendmentioning

confidence: 99%

“…During the service lifetime the performance of polymers can deteriorate through the aging process due to environmental factors such as temperature, UV radiation and humidity [163][164][165][166]. This alteration can lead to the decommissioning of these products [167][168][169][170][171]. The aging of polymer material is manifested in physical and chemical degradations, a slow and irreversible process.…”

Section: Afm-ir In Studying Polymer Agingmentioning

confidence: 99%

Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review

et al. 2020

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Atomic force microscopy (AFM) has been extensively used for the nanoscale characterization of polymeric materials. The coupling of AFM with infrared spectroscope (AFM-IR) provides another advantage to the chemical analyses and thus helps to shed light upon the study of polymers. This paper reviews some recent progress in the application of AFM and AFM-IR in polymer science. We describe the principle of AFM-IR and the recent improvements to enhance its resolution. We also discuss the latest progress in the use of AFM-IR as a super-resolution correlated scanned-probe infrared spectroscopy for the chemical characterization of polymer materials dealing with polymer composites, polymer blends, multilayers, and biopolymers. To highlight the advantages of AFM-IR, we report several results in studying the crystallization of both miscible and immiscible blends as well as polymer aging. Finally, we demonstrate how this novel technique can be used to determine phase separation, spherulitic structure, and crystallization mechanisms at nanoscales, which has never been achieved before. The review also discusses future trends in the use of AFM-IR in polymer materials, especially in polymer thin film investigation.

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Thermal properties and degradation of enantiomeric copolyesteramides poly(lactic acid-co-alanine)s

Cited by 8 publications

References 54 publications

Synthetic Biodegradable Polymers with Chain End Modification: Polylactide, Poly(butylene succinate), and Poly(hydroxyalkanoate)

Synthetic Biodegradable Polymers with Chain End Modification: Polylactide, Poly(butylene succinate), and Poly(hydroxyalkanoate)

Recent Advances of Poly(ester amide)s-Based Biomaterials

Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review

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