Thermo-sensitive injectable glycol chitosan-based hydrogel for treatment of degenerative disc disease

Li, Zhengzheng; Shim, Hye-Eun; Cho, Myeong Ok; Cho, Ik Sung; Lee, Jin Hyun; Kang, Sun-Woong; Kwon, Bosun; Huh, Kang Moo

doi:10.1016/j.carbpol.2018.01.006

Cited by 61 publications

(29 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thermo-sensitive injectable gels with good stability and thermosensitivity were developed from chitosan. The absence of adverse effects in vivo after the administration of the formulation was significant [93,94]. Ren et al developed dopamine-based and polydopamine crosslinked injectable hydrogels under physiological conditions.…”

Section: In Situ Gelmentioning

confidence: 99%

Chitosan-Based Nanocarriers for Nose to Brain Delivery

Aderibigbe

Naki

2019

Applied Sciences

View full text Add to dashboard Cite

In the treatment of brain diseases, most potent drugs that have been developed exhibit poor therapeutic outcomes resulting from the inability of a therapeutic amount of the drug to reach the brain. These drugs do not exhibit targeted drug delivery mechanisms, resulting in a high concentration of the drugs in vital organs leading to drug toxicity. Chitosan (CS) is a natural-based polymer. It has unique properties such as good biodegradability, biocompatibility, mucoadhesive properties, and it has been approved for biomedical applications. It has been used to develop nanocarriers for brain targeting via intranasal administration. Nanocarriers such as nanoparticles, in situ gels, nanoemulsions, and liposomes have been developed. In vitro and in vivo studies revealed that these nanocarriers exhibited enhanced drug uptake to the brain with reduced side effects resulting from the prolonged contact time of the nanocarriers with the nasal mucosa, the surface charge of the nanocarriers, the nano size of the nanocarriers, and their capability to stretch the tight junctions within the nasal mucosa. The aforementioned unique properties make chitosan a potential material for the development of nanocarriers for targeted drug delivery to the brain. This review will focus on chitosan-based carriers for brain targeting.

show abstract

Section: In Situ Gelmentioning

confidence: 99%

Chitosan-Based Nanocarriers for Nose to Brain Delivery

Aderibigbe

Naki

2019

Applied Sciences

View full text Add to dashboard Cite

show abstract

“…Interestingly, we found that HGC can effectively increase the proliferation of AD-MSCs even at a relatively low level of bFGF. This may be because HGC is better delivered to the cells due to its well-documented interaction with the glycosaminoglycans groups of the extracellular matrix [39,40,41], thus affecting cell proliferation. This study suggests that HGC may prove to be very useful as a biomaterial to produce high-quality and scalable AD-MSCs products.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Hexanoyl Glycol Chitosan on the Proliferation of Human Mesenchymal Stem Cells

Jeong

Lee

et al. 2018

Polymers

Self Cite

View full text Add to dashboard Cite

Adipose-derived mesenchymal stem cells (AD-MSCs) have been studied as desirable cell sources for regenerative medicine and therapeutic application. However, it has still remained a challenge to obtain enough adequate and healthy cells in large quantities. To overcome this limitation, various biomaterials have been used to promote expansion of MSCs in vitro. Recently, hexanoyl glycol chitosan (HGC) was introduced as a new biomaterial for various biomedical applications, in particular 3D cell culture, because of its biodegradability, biocompatibility, and other promising biofunctional properties. In this study, the effect of HGC on the proliferation of AD-MSCs was examined in vitro, and its synergistic effect with basic fibroblast growth factor (bFGF), which has been widely used to promote proliferation of cells, was evaluated. We found that the presence of HGC increased the proliferative capacity of AD-MSCs during long-term culture, even at low concentrations of bFGF. Furthermore, it suppressed the expression of senescence-related genes and improved the mitochondrial functionality. Taken all together, these findings suggest that the HGC demonstrate a potential for sustained growth of AD-MSCs in vitro.

show abstract

“…Depending on the hexanoylation degree and polymer concentration, these hydrogels expressed a sol-gel transition from 23 to 56°C. After implanting the hydrogels into the defective IVD using a porcine model, no cytotoxicity and adverse effects were found within 4 weeks in vivo , which indicated their alternative effects for the treatment of disk herniation ( Li et al, 2018 ).…”

Section: Naturally Derived Hydrogelsmentioning

confidence: 99%

“…(C) MRI images of IVD tissue before and 2 weeks after the disk degeneration process and subsequent degenerative IVD tissue at 2 weeks and 5 weeks after injection of HGC hydrogel in 30% alcohol solution. Reproduced from Li et al (2018) with permission from Copyright 2018 Elsevier.…”

Section: Naturally Derived Hydrogelsmentioning

confidence: 99%

Advances of Naturally Derived and Synthetic Hydrogels for Intervertebral Disk Regeneration

Tang

Zhou

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Intervertebral disk (IVD) degeneration is associated with most cases of cervical and lumbar spine pathologies, amongst which chronic low back pain has become the primary cause for loss of quality-adjusted life years. Biomaterials science and tissue engineering have made significant progress in the replacement, repair and regeneration of IVD tissue, wherein hydrogel has been recognized as an ideal biomaterial to promote IVD regeneration in recent years. Aspects such as ease of use, mechanical properties, regenerative capacity, and their applicability as carriers for regenerative and antidegenerative factors determine their suitability for IVD regeneration. This current review provides an overview of naturally derived and synthetic hydrogels that are related to their clinical applications for IVD regeneration. Although each type has its own unique advantages, it rarely becomes a standard product in truly clinical practice, and a more rational design is proposed for future use of biomaterials for IVD regeneration. This review aims to provide a starting point and inspiration for future research work on development of novel biomaterials and biotechnology.

show abstract

Thermo-sensitive injectable glycol chitosan-based hydrogel for treatment of degenerative disc disease

Cited by 61 publications

References 45 publications

Chitosan-Based Nanocarriers for Nose to Brain Delivery

Chitosan-Based Nanocarriers for Nose to Brain Delivery

The Effect of Hexanoyl Glycol Chitosan on the Proliferation of Human Mesenchymal Stem Cells

Advances of Naturally Derived and Synthetic Hydrogels for Intervertebral Disk Regeneration

Contact Info

Product

Resources

About