Thermoanalytical measurements conducted on repaglinide to estimate the kinetic triplet followed by compatibility studies between the antidiabetic agent and various excipients

Ceban, Iulia; Blajovan, Roxana; Vlase, Gabriela; Albu, Paul; Koppandi, Oana

doi:10.1007/s10973-016-5729-7

Cited by 13 publications

(2 citation statements)

References 14 publications

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“…Bioanalytical calorimetry measures the enthalpy change of a reaction. As biological reactions often are exothermic, calorimetry provides a useful tool to track a biological process by measuring the heat produced [1]. In early studies, calorimeters were designed in a sophisticated and expensive fashion, implying that their use in basic research and applied analyses was limited.…”

Section: Introductionmentioning

confidence: 99%

Pyrroloquinoline quinone glucose dehydrogenase adopted in thermometric analysis for enhancement of glucose determination

Xie

Bülow

Xie

2018

J Therm Anal Calorim

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A broad measurement range of glucose is often required in clinical analysis, especially for diabetic patients where glucose levels can be very high. Pyrroloquinoline quinone glucose dehydrogenase (PQQGDH) has previously been used in electrochemical quantification of glucose with an extended linear range. However, in real sample determination of glucose, interferences from electroactive substances in blood are unavoidable. Calorimetric biosensors, e.g., the Enzyme Thermistor, are insensitive to either directly electroactive or optical interferences often present in real clinical samples. This paper describes a novel analytical strategy where the intrinsic advantages of PQQGDH are combined with the Enzyme Thermistor as biosensor using calorimetric detection as general measurement principle. When compared with the most frequently used enzyme glucose oxidase, PQQGDH has a higher catalytic efficiency and is insensitive to the availability of oxygen. The use of calorimetry in this context resulted in a broad linear range of glucose measurements, from 0.009 to 100 mM, an excellent specificity and insignificant side effects of compounds present in blood at high concentrations, such as lactate and urea.

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Section: Introductionmentioning

confidence: 99%

Pyrroloquinoline quinone glucose dehydrogenase adopted in thermometric analysis for enhancement of glucose determination

Xie

Bülow

Xie

2018

J Therm Anal Calorim

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“…Secondly, the interactions between the drugs containing the carboxylic group and magnesium stearate were reported in the literature and they could not be negligible [42]. However, to some extent, these results were different than those that were reported in the literature, where no interactions between repaglinide and magnesium stearate were stated [44]. Thus, it is supposed that different conditions for the stability studies were used.…”

Section: Degradation In a Solid State And Impact Of Excipientsmentioning

confidence: 91%

Determination of Chemical Stability of Two Oral Antidiabetics, Metformin and Repaglinide in the Solid State and Solutions Using LC-UV, LC-MS, and FT-IR Methods

et al. 2019

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Firstly, metformin and repaglinide were degraded under high temperature/humidity, UV/VIS light, in different pH and oxidative conditions. Secondly, a new validated LC-UV method was examined, as to whether it validly determined these drugs in the presence of their degradation products and whether it is suitable for estimating degradation kinetics. Finally, the respective LC-MS method was used to identify the degradation products. In addition, using FT-IR method, the stability of metformin and repaglinide was scrutinized in the presence of polyvinylpyrrolidone (PVP), mannitol, magnesium stearate, and lactose. Significant degradation of metformin, following the first order kinetics, was observed in alkaline medium. In the case of repaglinide, the most significant and quickest degradation, following the first order kinetics, was observed in acidic and oxidative media (0.1 M HCl and 3% H2O2). Two new degradation products of metformin and nine new degradation products of repaglinide were detected and identified when the stressed samples were examined by our LC-MS method. What is more, the presence of PVP, mannitol, and magnesium stearate proved to affect the stability of metformin, while repaglinide stability was affected in the presence of PVP and magnesium stearate.

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An extensive compatibility study of mycophenolate mofetil with different excipients by spectroscopic and thermoanalytical investigation techniques

Vlase

Budiul

Pătruţescu

et al. 2017

J Therm Anal Calorim

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Thermoanalytical measurements conducted on repaglinide to estimate the kinetic triplet followed by compatibility studies between the antidiabetic agent and various excipients

Cited by 13 publications

References 14 publications

Pyrroloquinoline quinone glucose dehydrogenase adopted in thermometric analysis for enhancement of glucose determination

Pyrroloquinoline quinone glucose dehydrogenase adopted in thermometric analysis for enhancement of glucose determination

Determination of Chemical Stability of Two Oral Antidiabetics, Metformin and Repaglinide in the Solid State and Solutions Using LC-UV, LC-MS, and FT-IR Methods

An extensive compatibility study of mycophenolate mofetil with different excipients by spectroscopic and thermoanalytical investigation techniques

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