Thermodynamic Solubility Profile of Carbamazepine–Cinnamic Acid Cocrystal at Different pH

Keramatnia, Fatemeh; Shayanfar, Ali; Jouyban, Abolghasem

doi:10.1002/jps.24525

Cited by 40 publications

(29 citation statements)

References 43 publications

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“…The ionization of certain active components and coformers in aqueous solutions, such as basic coformers in highpH solutions, also contributes to the dissolution of cocrystals involving non-ionic APIs. 69,70) Many acidic and basic APIs generating both salts and cocrystals present higher solubility in their salts. 49) Cocrystals containing coformers exhibiting a lower intrinsic melting temperature tend to exhibit relatively higher solubility in aqueous solutions.…”

Section: Solubility and Dissolution Profile Of Cocrys-mentioning

confidence: 99%

Characterization and Quality Control of Pharmaceutical Cocrystals

Izutsu¹,

Koide²,

Takata

et al. 2016

Chem. Pharm. Bull.

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Recent active research and new regulatory guidance on pharmaceutical cocrystals have increased the rate of their development as promising approaches to improve handling, storage stability, and bioavailability of poorly soluble active pharmaceutical ingredients (APIs). However, their complex structure and the limited amount of available information related to their performance may require development strategies that differ from those of single-component crystals to ensure their clinical safety and efficacy. This article highlights current methods of characterizing pharmaceutical cocrystals and approaches to controlling their quality. Different cocrystal regulatory approaches between regions are also discussed. The physical characterization of cocrystals should include elucidating the structure of their objective crystal form as well as their possible variations (e.g., polymorphs, hydrates). Some solids may also contain crystals of individual components. Multiple processes to prepare pharmaceutical cocrystals (e.g., crystallization from solutions, grinding) vary in their applicable ingredients, scalability, and characteristics of resulting solids. The choice of the manufacturing method affects the quality control of particular cocrystals and their formulations. In vitro evaluation of the properties that govern clinical performance is attracting increasing attention in the development of pharmaceutical cocrystals. Understanding and mitigating possible factors perturbing the dissolution and/ or dissolved states, including solution-mediated phase transformation (SMPT) and precipitation from supersaturated solutions, are important to ensure the bioavailability of orally administrated lower-solubility APIs. The effect of polymer excipients on the performance of APIs emphasizes the relevance of formulation design for appropriate use.

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Section: Solubility and Dissolution Profile Of Cocrys-mentioning

confidence: 99%

Characterization and Quality Control of Pharmaceutical Cocrystals

Izutsu¹,

Koide²,

Takata

et al. 2016

Chem. Pharm. Bull.

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“…Salts, co-crystals, polymorphs, solvates and hydrates are of general interest. Furthermore, there is a research interest in organic salts because of their brilliant properties [8][9][10][11]. …”

Section: Discussionmentioning

confidence: 99%

Crystal structure of the salt 1,1′-(ethane-1,2-diyl)bis(1,4-diazabicyclo[2.2.2]octan-1-ium) diperchlorate, C₁₄H₂₈N₄(ClO₄)₂

Wen

2017

Zeitschrift Für Kristallographie - New Crystal Structures

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CCDC no.: 1527555The crystal structure is shown in the figure. Tables 1 and 2 contain details on crystal structure and measurement conditions and a list of the atoms including atomic coordinates and displacement parameters. Source of material Experimental detailsHydrogen atoms were placed in calculated positions and refined as a riding mode, with C-H = 0.96 Å (methylene) with U iso (H) = 1.2 U eq (C). DiscussionOrganic-inorganic crystalline materials can be exploited for many purposes such as nonlinear optical materials, dielectric, piezoelectric, pyroelectric, ferroelectric, semiconductors and other physical properties [4][5][6][7].

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“…125 It was reported that solution stability of carbamazepine-cinnamic Acid cocrystal depends upon solubility of coformers while further shown that carbamazepine-nicotinamide cocrystal was unstable in water, addition of ethanol could improve stability. 126,127 These understandings can serve as a guide for the selection of coformers and surfactants to control its solubility and transformation during manufacturing, storage, and evaluation.…”

Section: Impact On Chemical Stabilitymentioning

confidence: 99%

Pharmaceutical Cocrystals: Regulatory and Strategic Aspects, Design and Development

Gadade¹,

Pekamwar²

2016

Adv Pharm Bull

124

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Thermodynamic Solubility Profile of Carbamazepine–Cinnamic Acid Cocrystal at Different pH

Cited by 40 publications

References 43 publications

Characterization and Quality Control of Pharmaceutical Cocrystals

Characterization and Quality Control of Pharmaceutical Cocrystals

Crystal structure of the salt 1,1′-(ethane-1,2-diyl)bis(1,4-diazabicyclo[2.2.2]octan-1-ium) diperchlorate, C₁₄H₂₈N₄(ClO₄)₂

Pharmaceutical Cocrystals: Regulatory and Strategic Aspects, Design and Development

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Thermodynamic Solubility Profile of Carbamazepine–Cinnamic Acid Cocrystal at Different pH

Cited by 40 publications

References 43 publications

Characterization and Quality Control of Pharmaceutical Cocrystals

Characterization and Quality Control of Pharmaceutical Cocrystals

Crystal structure of the salt 1,1′-(ethane-1,2-diyl)bis(1,4-diazabicyclo[2.2.2]octan-1-ium) diperchlorate, C14H28N4(ClO4)2

Pharmaceutical Cocrystals: Regulatory and Strategic Aspects, Design and Development

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Crystal structure of the salt 1,1′-(ethane-1,2-diyl)bis(1,4-diazabicyclo[2.2.2]octan-1-ium) diperchlorate, C₁₄H₂₈N₄(ClO₄)₂