Thermolabile Methylenetetrahydrofolate Reductase C677T Polymorphism and Homocysteine Are Risk Factors for Coronary Artery Disease in Moroccan Population

Bennouar, Nawal; Allami, Abdellatif; Azeddoug, Houssine; Bendris, Abdenbi; Laraqui, Abdelilah; Jaffali, Amal El; Kadiri, Nizar El; Benzidia, Rachid; Benomar, A.; Fellat, S.; Benomar, M.

doi:10.1155/2007/80687

Cited by 22 publications

(25 citation statements)

References 43 publications

(43 reference statements)

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“…Previous studies have reported Hcy concentrations ranging from 6 µmol/L in Japan to 13 µmol/L in South Africa in healthy subjects [4]. In the Iranian population, Hcy concentrations were lower [7. µmol/L] [7]. The similar levels of Hcy in Syria and Morocco compared with our findings may be due to similarities in food intake habits.…”

Section: Discussionsupporting

confidence: 79%

Total homocysteine levels and cardiovascular risk factors in healthy Tunisians

Oudi¹,

Aouni²,

Mazigh³

et al. 2011

East Mediterr Health J

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Hyperhomocysteinaemia is considered as an important independent risk factor for atherosclerosis and thrombotic disease. This study determined the distribution of homocysteine (Hcy) levels in healthy Tunisian subjects and evaluated the relationship between Hcy levels and some cardiovascular risk factors. Randomly selected subjects (592 men and 114 women) were recruited from different regions of Tunisia. The overall mean Hcy level was 12.6 (SD 5.4) µmol/L. Hcy levels in subjects with hyperhomocysteinaemia varied according to geographical region. Subjects with hyperhomocysteinaemia had significantly elevated total cholesterol, LDL cholesterol, apolipoprotein A and apolipoprotein B and lower vitamin B 12 levels compared with subjects with normohomocysteinaemia. Hcy levels correlated with total cholesterol (r = 0.09), apolipoprotein A (r = 0.012), and B (r = 0.013) levels and total/HDL cholesterol ratio (r = -0.085). Further epidemiological studies are needed to determine the precise role of Hcy in cardiovascular disease.

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Section: Discussionsupporting

confidence: 79%

Total homocysteine levels and cardiovascular risk factors in healthy Tunisians

Oudi¹,

Aouni²,

Mazigh³

et al. 2011

East Mediterr Health J

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“…Genes encoding proteins that perform or support these conversions include MTHFD1, MTHFR, MTR, and MTRR. MTHFR polymorphisms are widely studied in coronary artery disease, neural tube defects, and facial clefts [selected recent publications: Bennouar et al, 2007;Chevrier et al, 2007;Munoz et al, 2007]. The folate cycle is coupled to one-carbon metabolism by the MTR-mediated conversion of homocysteine to methionine.…”

Section: Discussionmentioning

confidence: 99%

Folate and one‐carbon metabolism gene polymorphisms and their associations with oral facial clefts

Boyles

Wilcox

Taylor

et al. 2008

American J of Med Genetics Pt A

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Folate metabolism plays a critical role in embryonic development. Prenatal folate supplementation reduces the risk of neural tube defects and probably oral facial clefts. Previous studies of related metabolic genes have associated polymorphisms in cystathionine-beta-synthase (CBS) and 5,10-methylenetetrahydrofolate reductase (MTHFR) with cleft risk. We explored associations between genes related to one-carbon metabolism and clefts in a Norwegian population-based study that included 362 families with cleft lip with or without cleft palate (CL/P) and 191 families with cleft palate only (CPO). We previously showed a 39% reduction in risk of CL/P with folic acid supplementation in this population. In the present study we genotyped 12 polymorphisms in nine genes related to one-carbon metabolism and looked for associations of clefting risk with fetal polymorphisms, maternal polymorphisms, as well as parent-of-origin effects, using combined likelihood-ratio tests (LRT). We also stratified by maternal periconceptional intake of folic acid (>400 microg) to explore gene-exposure interactions. We found a reduced risk of CL/P with mothers who carried the CBS C699T variant (rs234706); relative risk was 0.94 with one copy of the T allele (95% CI 0.63-1.4) and 0.50 (95% CI 0.26-0.96) with two copies (P = 0.008). We found no evidence of interaction of this variant with folate status. We saw no evidence of risk from the MTHFR C677T variant (rs1801133) either overall or after stratifying by maternal folate intake. No associations were found between any of the polymorphisms and CPO. Genetic variations in the nine metabolic genes examined here do not confer a substantial degree of risk for clefts.

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“…Em DAC, o alelo polimórfico foi observado significantemente mais freqüente nos pacientes em relação aos controles [10][11][12][13][14]25 . Em estudo brasileiro, o polimorfismo foi associado à gravidade da doença, mas não apresentou distribuição significantemente diferente entre pacientes com e sem DAC 26 .…”

Section: Discussionunclassified

Variabilidade genética MTHFR no desenvolvimento da doença arterial coronária

Biselli¹,

Guerzoni²,

Goloni-Bertollo³

et al. 2009

Rev. Assoc. Med. Bras.

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ResumoObjetivO. Concentração elevada de homocisteína (Hcy) é considerada um fator de risco para doença arterial coronária (DAC). Alterações genéticas da enzima metilenotetrahidrofolato redutase (MTHFR), envolvida no metabolismo da Hcy, podem reduzir sua termolabilidade contribuindo para o desenvolvimento de lesões ateroscleróticas. O objetivo deste estudo foi investigar a relação entre os polimorfismos MTHFR C677T e A1298C e a presença, extensão e gravidade da DAC. MétOdOs. Foram avaliados 175 pacientes com DAC, confirmada por angiografia e 108 indivíduos sem DAC (grupo controle). O polimorfismo MTHFR C677T foi investigado por reação em cadeia da polimerase (PCR) seguida de digestão enzimática. A genotipagem do polimorfismo MTHFR A1298C foi realizada pela técnica de PCR alelo-específica. ResultadOs. A frequência do alelo alterado MTHFR 677C foi de 0,38 no grupo DAC e 0,37 no grupo controle. Em relação ao alelo polimórfico MTHFR 1298C, a frequência foi de 0,22 e 0,27, respectivamente. As distribuições genotípicas MTHFR C677T e A1298C não diferiram em relação ao número de artérias lesadas (P > 0,05). Também não foi observada relação entre o polimorfismo para MTHFR C677T e grau de obstrução arterial coronária (P > 0,05), assim como MTHFR A1298C (P > 0,05). COnClusãO. Nossos resultados não demonstraram associação entre os polimorfismos MTHFR A1298C e MTHFR C677T e presença, extensão ou gravidade da DAC.Unitermos: Doença arterial coronária. Polimorfismos genéticos. Enzima MTHFR.

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Thermolabile Methylenetetrahydrofolate Reductase C677T Polymorphism and Homocysteine Are Risk Factors for Coronary Artery Disease in Moroccan Population

Cited by 22 publications

References 43 publications

Total homocysteine levels and cardiovascular risk factors in healthy Tunisians

Total homocysteine levels and cardiovascular risk factors in healthy Tunisians

Folate and one‐carbon metabolism gene polymorphisms and their associations with oral facial clefts

Variabilidade genética MTHFR no desenvolvimento da doença arterial coronária

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