There's a lack of understanding on the root cause of cracking of photovoltaic (PV) backsheets due to the challenge of multilayer characterization and the complicated failure modes at the sub-module level. In this work, in-depth degradation mapping of field-exposed polyamide-based (PA-based) PV module backsheets was studied, with the major focus on the identification of underlying drivers for the through cracking (in between the solar cells). PV modules were retrieved from five different locations, comprising a variety of climates, including humid subtropical, hot-summer Mediterranean, tropical savanna climate and hot arid. A suite of microscale cross-sectional characterizations, including chemical changes, fluorescence intensity, and modulus as a function of distance from the air surface of the backsheet, were performed. Results showed more advanced signs of degradation of the inner layer than the outer layer in the cracking region. Increases in the modulus was identified as the major indicator for the cracking. Moreover, a rudimentary test by immersion in acetic acid, which forms during photodegradation of the ethylene-vinyl acetate copolymer (EVA) encapsulant, showed the first-time direct evidence that acetic acid can largely accelerate the chemical degradation and facilitate the cracking of PA inner layer. This study suggests that the field cracking of PA-based backsheet can be attributed to the combined effects of chemical degradation and physical reorganization (chemi-crystallization) under cyclic thermomechanical stresses. Therefore, it is important to consider effects of local