Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface

Murakami, Daiki; Kitahara, Yoko; Kobayashi, Shū; Tanaka, Masaru

doi:10.1021/acsbiomaterials.8b00081

Cited by 17 publications

(25 citation statements)

References 30 publications

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“…This value is obviously less than the stiffness of the substrate, indicating that the surface unevenness at PMEA/PBS is not generated by a dewetting phenomenon of polymer on the substrate. The relationship between the interfacial structure in a thermosensitive biocompatible polymer and the protein adsorption and cell adhesion was investigated by Murakami et al ( 2018 ). As the region with polymer-rich domains at the interface decreases (in which the water-rich domains increase) with a change in temperature, the amounts of adsorbed fibrinogen (FNG) and platelet adhesion decrease.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Interaction Between Interfacial Structure and Fibrinogen at Blood-Compatible Polymer/Water Interface

2018

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The correlation between the interfacial structure and protein adsorption at a polymer/water interface was investigated. Poly(2-methoxyethyl acrylate)(PMEA), which is one of the best blood compatible polymers available, was employed. Nanometer-scale structures generated through the phase separation of polymer and water were observed at the PMEA/phosphate buffered saline interface. The interaction between the interfacial structures and fibrinogen (FNG) was measured using atomic force microscopy. Attraction was observed in the polymer-rich domains as well as in the non-blood compatible polymer. In contrast, no attractive interactions were observed, and only a repulsion occurred in the water-rich domains. The non-adsorption of FNG into the water rich domains was also clarified through topographic and phase image analyses. Furthermore, the FNG molecules adsorbed on the surface of PMEA were easily desorbed, even in the polymer-rich domains. Water molecules in the water-rich domains are anticipated to be the dominant factor in preventing FNG adsorption and thrombogenesis on a PMEA interface.

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Section: Introductionmentioning

confidence: 99%

Analysis of Interaction Between Interfacial Structure and Fibrinogen at Blood-Compatible Polymer/Water Interface

2018

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“…However, these biomaterials properties (e.g., size, shape, surface area, roughness, and chemical composition) influence the host response, causing variations in the intensity and duration of the inflammatory and wound healing processes. These define the biocompatibility of the polymers and scaffolds [ 136 ].…”

Section: Bioengineered Thermo-responsive Scaffoldsmentioning

confidence: 99%

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

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Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

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“…The height of the protrusions for H-PMEA has the same range as previously found for PMEA: 50 -80 microns. [1][2][3]6,[34][35][36] However, the numbers of the soft protrusions/hills seem to be more and at the same time the areas of the valleys are smaller in H-PMEA as compared to PMEA, probably because of these two being hydrophobic and hydrophilic, respectively. These facts resulted in the less pronounced phase separation of H-PMEA clearly visible in its 2D and 3 D images.…”

Section: Afm Of the Hydrated Polymersmentioning

confidence: 99%

Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)

Jankova

Javakhishvili

Kobayashi

et al. 2019

ACS Appl. Bio Mater.

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The practical use of the viscous liquid polymer, poly(2-methoxyethyl acrylate) (PMEA) was expanded from thin films with excellent blood compatibility to thick coatings and free-standing films without essentially sacrificing its blood compatibility. This was undertaken by creating multiple hydrogen-bonding polymer networks by introducing a functional methacrylic monomer bearing a 6-methyl-2-ureido-4[1H]-pyrimidone group in the PMEA backbone via free radical copolymerization. The hydrogen-bonded PMEA (H-PMEA) contained about 6 mol% of the functional monomer in the copolymer. These functional monomers as physical cross-links are distributed in the PMEA matrix with a T g of 35 C, making H-PMEA solid rubber-like material with Page 2 of 39 ACS Paragon Plus Environment ACS Applied Bio Materials 3recoverable tensile strain. Additionally, mechanical tests revealed its tensile strength, and thermogravimetric analyses confirmed its higher thermostability. The dry and hydration states of H-PMEA were assessed by differential scanning calorimetry, contact angle, and atomic force microscopy measurements. Comparison with viscous PMEA was made. For the first time, we included PVC alongside with PET, the surface we usually use as a negative control, in the platelet adhesion test with human blood, and found out that 1.5 times more platelets adhered onto the PVC surface than onto the PET surface, while H-PMEA proved to have a clear edge. Thus, H-PMEA may serve as a suitable replacement of polymers in products contacting blood as it shows potential for making free-standing films, thick coatings, implants and articles with various geometries for the medicinal industry.

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Thermosensitive Polymer Biocompatibility Based on Interfacial Structure at Biointerface

Cited by 17 publications

References 30 publications

Analysis of Interaction Between Interfacial Structure and Fibrinogen at Blood-Compatible Polymer/Water Interface

Analysis of Interaction Between Interfacial Structure and Fibrinogen at Blood-Compatible Polymer/Water Interface

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Hydration States and Blood Compatibility of Hydrogen-Bonded Supramolecular Poly(2-methoxyethyl acrylate)

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