A simple and rapid high performance thin layer chromatography (HPTLC) densitometric method has been developed for determination of betamethasone base in the tablets. After extraction of the analyte with 96% ethanol, the extracts were spotted on precoated HPTLC silica gel plates, which were then developed with a mixture of chloroformmethanol-water (18 : 5 : 0.5). Quantitative evaluation was performed by measuring the absorbance reflectance of the analyte spots at 245 nm. The densitometric method is selective, precise, and accurate and can be used for routine analysis of the tablet preparations in pharmaceutical industry quality control laboratories.