2017
DOI: 10.5350/dajpn2017300203
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Thiol/disulphide homeostasis in men with heroin addiction

Abstract: Thiol/disulphide homeostasis in men with heroin addictionObjective: Heroin addicts have increased oxidative stress which can disturb thiol/disulfide (SH/SS) homeostasis, causing disulfide formation. No study has determined the serum thiol amount and blood disulfide amount in heroin addicts. The aim of the study was to investigate dynamic SH/SS homeostasis in heroin addicts.Methods: Serum SH/SS statuses of 31 heroin addicts and 31 healthy controls were compared to determine the changes in SH/SS homeostasis in h… Show more

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Cited by 4 publications
(2 citation statements)
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“…In a case-control study conducted by Kotan et al . [ 27 ] on heroin addicts, native thiol and total thiol levels were found to be significantly lower in the patient group compared to the CG, while disulfide levels were found to be higher. The duration of substance use was, however, reported not to be significantly associated with these variables [ 27 ].…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…In a case-control study conducted by Kotan et al . [ 27 ] on heroin addicts, native thiol and total thiol levels were found to be significantly lower in the patient group compared to the CG, while disulfide levels were found to be higher. The duration of substance use was, however, reported not to be significantly associated with these variables [ 27 ].…”
Section: Discussionmentioning
confidence: 96%
“…[ 27 ] on heroin addicts, native thiol and total thiol levels were found to be significantly lower in the patient group compared to the CG, while disulfide levels were found to be higher. The duration of substance use was, however, reported not to be significantly associated with these variables [ 27 ]. In studies conducted with patients using cannabis and synthetic cannabinoids, an increase in inflammation and oxidative stress has been reported [ 28 , 29 ].…”
Section: Discussionmentioning
confidence: 99%