Third Annual World Congress on the Insulin Resistance Syndrome

Bloomgarden, Zachary T.

doi:10.2337/dc06-zb07

Cited by 7 publications

(4 citation statements)

References 55 publications

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“…Although often linked to acute pain, hsCRP has been less consistently associated with chronic pain [7]. We tested 3 separate surrogate markers of insulin resistance in our models, but recognize that these measures are only approximations of the euglycemic clamp and may have underestimated the role of insulin resistance in determining the probability of having pain [3]. …”

Section: Discussionmentioning

confidence: 99%

Mechanisms of association between obesity and chronic pain in the elderly

Ray

Lipton

Zimmerman

et al. 2011

Pain

168

122

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Chronic pain is more common in the elderly and impairs functioning and quality of life. Though obesity, defined by body mass index (BMI), has been associated with pain prevalence among older adults, the mechanism of this association remains unclear. We examined components of the metabolic syndrome, insulin resistance, a marker of inflammation, and the presence of painful comorbidities as possible mediators of this association. Participants were 407 individuals age • 70 in the Einstein Aging Study. Chronic pain and pain over the last 3 months were defined using the Total Pain Index (TPI). Insulin resistance was modeled as fasting insulin, HOMA and QUICKI. High sensitivity C-reactive protein was used as a marker of inflammation. Cross-sectional logistic regression models were constructed to assess the associations of these factors with prevalent pain, adjusted for other known pain correlates. Prevalence of chronic pain was 52%. Of the clinical components of metabolic syndrome, central obesity was significantly associated with pain (OR 2.03, 95% CI 1.36-3.01). After adjustment for insulin resistance, inflammation, and pain-related comorbidities, central obesity predicted higher TPI scores (OR 1.55, 95% CI 1.04-2.33) and nearly doubled the risk of chronic pain (OR 1.70, 95% CI 1.05-2.75). Central obesity is the metabolic syndrome component showing the strongest independent association with pain, and the relationship is not explained by markers of insulin resistance or inflammation, nor by the presence of osteoarthritis or neuropathy.

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Section: Discussionmentioning

confidence: 99%

Mechanisms of association between obesity and chronic pain in the elderly

Ray

Lipton

Zimmerman

et al. 2011

Pain

168

122

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“…Citokinas mediadoras de la respuesta inflamatorias están asociadas a insulinorresistencia, disfunción endotelial y enfermedad ateroesclerótica 44 .…”

Section: Fármacounclassified

Alteraciones metabólicas asociadas al uso de terapia antipsicótica

A²,

et al. 2009

Rev. méd. Chile

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“…However, this is considered impractical for routine clinical use; therefore, a minimal model assessment [dynamic testing with oral glucose loading - oral glucose tolerance test (OGTT)] and homeostatic models (glucose and insulin measurements obtained from fasting states - HOMA, QUICKI) have been used for this purpose [7,8]. Kirwan et al [9] validated the homeostatic models for use in pregnancy, although the OGTT is also used in pregnancy for the diagnosis of gestational diabetes [10].…”

Section: Introductionmentioning

confidence: 99%

Role of the Glucose Tolerance Test as a Predictor of Preeclampsia

Parra-Cordero

Sepúlveda‐Martínez

Preisler

et al. 2014

Gynecol Obstet Invest

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Objective: To determine whether oral glucose tolerance tests (OGTT) play a role as predictors of preeclampsia (PET) in pregnant women. Methods: A retrospective case-control study was conducted in 2,002 singleton pregnancies that had a uterine artery (UtA) Doppler at 22-25 weeks and an OGTT. The UtA Doppler and OGTT were adjusted based on maternal characteristics, and the results were expressed as multiples of the expected normal median and compared between groups. Logistic regression analysis was used to determine whether maternal characteristics, OGTT, and UtA Doppler significantly contribute to the prediction of early- (<34 weeks), intermediate- (34-37 weeks), or late-onset (>37 weeks) PET. The performance of the screening was determined by ROC curves. Results: Women who developed PET were characterized by an older maternal age, an increased body mass index, and an altered UtA Doppler. The group with intermediate-onset PET was the only one associated with higher 2-hour OGTT levels compared to controls. Combined models were developed via logistic regression analysis using maternal characteristics, UtA Doppler, and OGTT to predict PET. These combined models were able to detect around 74, 42, and 21% of women who later developed early-, intermediate-, or late-onset PET, respectively, with only a 5% false-positive rate. Conclusions: This study shows that the combination of maternal characteristics, second-trimester UtA Doppler, and OGTT is a predictor of the development of PET in healthy pregnant women.

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Third Annual World Congress on the Insulin Resistance Syndrome

Cited by 7 publications

References 55 publications

Mechanisms of association between obesity and chronic pain in the elderly

Mechanisms of association between obesity and chronic pain in the elderly

Alteraciones metabólicas asociadas al uso de terapia antipsicótica

Role of the Glucose Tolerance Test as a Predictor of Preeclampsia

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