Thirty-Two-Year Dynamics and Prognostic Significance of Baseline Levels of Systemic Pressure in Teenage Boys

Александров, А. А.; Зволинская, Е. Ю.; Пугоева, Х. С.; Иванова, Е. И.

doi:10.15829/1728-8800-2017-5-63-71

Cited by 3 publications

(2 citation statements)

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“…(13) It is known that AH in humans is also associated with severe pathological conditions accompanied by numerous polysystem disorders, decreased immunity, early occurrence of atherogenic shifts, a significant imbalance of neurovegetative and endocrine influences, and significant changes in central and regional hemodynamics. (3,6) When analyzing the experimental data, we found that rats of the ISIAH line have a high activity of LPO reactions (an increase in the final TBA-active products). Our data are consistent with the results of a number of studies indicating the altered reactivity of various systems in animals of this line.…”

Section: Resultsmentioning

confidence: 96%

“…(1,2) AH often manifests itself in childhood and adolescence. (3,4) Like any pathological condition, AH, in addition to pathological reactions, is accompanied by the inclusion of sanogenetic mechanisms reflecting the dynamic complex of defense and adaptive reactions arising under the influence of a pathogenic factor and aimed at restoring the disturbed selfregulation of the body. (5,6) Sanogenetic reactions at the cellular level consist in plastic rearrangements of cell membranes, intracellular structures, macromolecules and their medium.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Analysis of Lipid Peroxidation System in Humans and Rats with Arterial Hypertension

Darenskaya¹,

Kolesnikova²,

Rychkova³

et al. 2019

IJBM

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The aim of this research was to study the concentration of lipid peroxidation (LPO) products and the activity of antioxidant defense (AOD) parameters in ISIAH rats in comparison with a group of adolescents with arterial hypertension (AH). Material and Methods:We conducted the study on young (2.5-3 months) sexually mature male rats of the normotensive line (WAG) (n=20) (intact animals) and hypertensive line (ISIAH) (n=20), weighing 200-220 g. The data of 65 adolescents aged 13-17 years with AH (Group 1) were used for the clinical study (the age of adolescents is comparable to the biological age of the experimental animals used). The comparison group consisted of 65 normotensive adolescents of the same age and sex ("copypair" type) (Group 2). The plasma level of antioxidant parameters (total antioxidant activity [TTA], SOD activity, α-tocopherol and retinol) and primary/secondary products of LPO (conjugated dienes [CD], ketodienes and conjugated trienes [KD-CT], and thiobarbituric acid reactants [TBARs]) were determined using spectrophotometric and fluorometric methods.Results: We found that the course of LPO reactions in animals and humans was similar, which was expressed by the activation of prooxidant factors and the insufficiency of antioxidant response. Species differences concerned the intensity and number of parameters involved in the pathological process. Thus, in ISIAH rats there was an increase in toxic TBA-active products and a decrease in TTA, α-tocopherol and retinol in comparison with normotensive animals; in AH adolescents there was an increase in the content of intermediate-KD-CT and final TBA-active products, and a decrease in the α-tocopherol level in relation to the comparison group.Conclusion: Features of response of the LPO nonspecific system in hypertensive rats and humans allow using this line of rats for further study of adaptive mechanisms, and to extrapolate the received experimental data on humans, taking into account certain specific distinctions.(International Journal of Biomedicine. 2019;9(4):292-296.)

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Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Lipid Peroxidation System in Humans and Rats with Arterial Hypertension

Darenskaya¹,

Kolesnikova²,

Rychkova³

et al. 2019

IJBM

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Predictive significance of raised blood pressure in children and adolescents (32-year prospective follow-up)

Александров

Розанов

Пугоева

et al. 2018

Cardiovasc Ther Prev

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Although on the first glance, the prevention of arterial hypertension (AH) is effective since childhood and adolescence, further research is needed, as it is not well known how to make it effective.Aim. Based upon the analysis of 32-year long dynamics of various levels of blood pressure (BP), to define the efficacy of screening investigations in children.Material and methods. A 32-year long prospective, cohort study conducted, the observation of males beginning at age 11-12 y. o. In 32 years, among 1005 participants, 303 (30,1%) were investigated, and the cohort consisted finally of 290 persons. The assessment included: surveying, triple BP measurement, pulse count, body mass and height measurement, triceps skin folds thickness measurement, as scapular and abdominal, waist and hip circumference, total cholesterol measurement, as the high density, and level of triglycerides, electrocardiogram.Results. Among the males that at the age 12 were in the upper 20% (5th quintile) by systolic BP, in 32 years almost one quarter remained in the same quintile. The stability of raised BP the parameters influence such as body mass and skin fold thickness. Combination of raised systolic BP in high body mass in 13 y. o. adolescents does increase the risk of AH at 43 y. o. the same grade that does an isolated body mass increase — this witness on the decrease of baseline BP values role in hypertension developemnt with remaining role of body mass. The risk of AH development with the baseline age 15 y. o. was significantly higher in combination of overweight and AH.Conclusion. For AH prevention, even in childhood and adolescence it necessary to monitor closely those with raised systolic BP and overweight, and active prevention should start before the age 20 y. o.

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Dental health of adolescents with arterial hypertension: rationale for approaches to prevention using calcium glycerophosphate and magnesium chloride

Kolesnikova¹,

Погодина²,

Федотова³

et al. 2018

Ross. vestn. perinatol. pediatr.

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Summary. Objective: to characterize the dental health of adolescents with arterial hypertension and to increase its level with a complex of therapeutic and prophylactic measures based on the results obtained. The study included 130 adolescents (65 – with arterial hypertension and 65 – control group) of 14.3 ± 2 years old. The level of systolic blood pressure in the main group was higher than that of the adolescents in the control group (126.6 ± 12.6 mm Hg vs 113.2 ± 7.4 mm Hg, p=0.00009), while the level of diastolic blood pressure was comparable. The data obtained suggest that adolescents with arterial hypertension are characterized by unsatisfactory oral hygiene indicators and a significantly higher incidence of major dental diseases: dental caries and periodontitis. It justifies the selection of adolescents with arterial hypertension in a group that is vulnerable both to the development of new and to the progression of existing diseases of the dental-maxillary system, which can significantly worsen cardiovascular health. Therefore, there is a need to develop a system of preventive actions built on the basis of an interdisciplinary approach with the active participation of somatic and dental specialists.Conflict of interest: The authors of this article confirmed the lack of conflict of interest and financial support, which should be reported.

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Thirty-Two-Year Dynamics and Prognostic Significance of Baseline Levels of Systemic Pressure in Teenage Boys

Cited by 3 publications

References 0 publications

Comparative Analysis of Lipid Peroxidation System in Humans and Rats with Arterial Hypertension

Comparative Analysis of Lipid Peroxidation System in Humans and Rats with Arterial Hypertension

Predictive significance of raised blood pressure in children and adolescents (32-year prospective follow-up)

Dental health of adolescents with arterial hypertension: rationale for approaches to prevention using calcium glycerophosphate and magnesium chloride

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