Three-Dimensional Bio-Printed Scaffold Sleeves With Mesenchymal Stem Cells for Enhancement of Tendon-to-Bone Healing in Anterior Cruciate Ligament Reconstruction Using Soft-Tissue Tendon Graft

Park, Sin Hyung; Choi, Yeong‐Jin; Moon, Sang Won; Lee, Byung‐Hoon; Shim, Jin‐Hyung; Cho, Dong‐Woo; Wang, Joon Ho

doi:10.1016/j.arthro.2017.04.016

Cited by 64 publications

(54 citation statements)

References 50 publications

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“…It can precisely fabricate scaffolds with defined shape, size, porosity, and pore size distribution, which is beneficial for bone growth. 127,128 In addition, more and more complex orthopedic diseases can be solved based on this technique. 129 In this section, we discuss the silver-containing 3D scaffolds in orthopedic field.…”

Section: Plasma Electrolytic Oxidation (Peo)mentioning

confidence: 99%

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Qing

Cheng

et al. 2018

IJN

764

362

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Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized.

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Section: Plasma Electrolytic Oxidation (Peo)mentioning

confidence: 99%

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Qing

Cheng

et al. 2018

IJN

764

362

View full text Add to dashboard Cite

show abstract

“…(Ramdass & Koka, 2015) (Tucker, Karamsadkar, Khan, & Pastides, 2010) The efficacy of bone marrow MSCs in the treatment of flexor tendon injury of the equine finger is superior to that of PRP and adipose tissue‐derived MSCs (Romero et al, 2017). Some studies have found that the utilization of MSCs in soft tissue tendon transplantation and reconstruction of the ACL can promote repair and regeneration, which provides the possibility of more physiological and biomechanical ligament reconstruction (Jang, Lim, Jung, Moon, & Wang, 2015; Lim et al, 2004; Park et al, 2018; Van Loon, Scheffer, Genn, Hoogendoorn, & Greve, 2014; Zhang et al, 2017). Moreover, ESCs have almost unlimited developmental potential and self‐renewal ability and can differentiate into almost any kind of organism cell type (Wobus & Boheler, 2005).…”

Section: Engineering Methodsmentioning

confidence: 99%

Injectable hydrogels for tendon and ligament tissue engineering

Liu

Zhang

Chen

2020

J Tissue Eng Regen Med

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The problem of tendon and ligament (T/L) regeneration in musculoskeletal diseases has long constituted a major challenge. In situ injection of formable biodegradable hydrogels, however, has been demonstrated to treat T/L injury and reduce patient suffering in a minimally invasive manner. An injectable hydrogel is more suitable than other biological materials due to the special physiological structure of T/L. Most other materials utilized to repair T/L are cell‐based, growth factor‐based materials, with few material properties. In addition, the mechanical property of the gel cannot reach the normal T/L level. This review summarizes advances in natural and synthetic polymeric injectable hydrogels for tissue engineering in T/L and presents prospects for injectable and biodegradable hydrogels for its treatment. In future T/L applications, it is necessary develop an injectable hydrogel with mechanics, tissue damage‐specific binding, and disease response. Simultaneously, the advantages of various biological materials must be combined in order to achieve personalized precision therapy.

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“…Twisting angles a (degrees) tendon and ligament tissues. However, there are significant challenges to be resolved in terms of technological progresses [133,134].…”

Section: Scaffold Levelsmentioning

confidence: 99%

Biodegradable polymer nanocomposites for ligament/tendon tissue engineering

et al. 2020

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Ligaments and tendons are fibrous tissues with poor vascularity and limited regeneration capacity. Currently, a ligament/tendon injury often require a surgical procedure using auto-or allografts that present some limitations. These inadequacies combined with the significant economic and health impact have prompted the development of tissue engineering approaches. Several natural and synthetic biodegradable polymers as well as composites, blends and hybrids based on such materials have been used to produce tendon and ligament scaffolds. Given the complex structure of native tissues, the production of fiber-based scaffolds has been the preferred option for tendon/ligament tissue engineering. Electrospinning and several textile methods such as twisting, braiding and knitting have been used to produce these scaffolds. This review focuses on the developments achieved in the preparation of tendon/ ligament scaffolds based on different biodegradable polymers. Several examples are overviewed and their processing methodologies, as well as their biological and mechanical performances, are discussed. Fig. 20 a 3D view of the theoretical designed PLA screw-like scaffold structure. b The prepared PLA screw-like scaffold. c The SEM image of the PLA scaffold surface with well-defined orthogonal structure (Reprinted with permission from [114])

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Three-Dimensional Bio-Printed Scaffold Sleeves With Mesenchymal Stem Cells for Enhancement of Tendon-to-Bone Healing in Anterior Cruciate Ligament Reconstruction Using Soft-Tissue Tendon Graft

Cited by 64 publications

References 50 publications

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Injectable hydrogels for tendon and ligament tissue engineering

Biodegradable polymer nanocomposites for ligament/tendon tissue engineering

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