Three-dimensional Dynamic Susceptibility-weighted Perfusion MR Imaging at 3.0 T: Feasibility and Contrast Agent Dose

Manka, Christoph; Träber, Frank; Gieseke, J; Schild, Hans H.; Kuhl, Christiane K.

doi:10.1148/radiol.2343040359

Cited by 52 publications

(44 citation statements)

References 48 publications

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“…12,15,17,20,21 Previous studies investigated the relationship between preload amount and T1-weighted leakage correction; however, the issue remains unresolved 15,17,21 and is likely further confounded at higher field strengths. Because 3T DSC enables a smaller contrast bolus compared with 1.5T with similar data quality, 22 we used a stepwise preload dosing protocol with half-dose incremental steps as part of a separate study to optimize T1-weighted leakage correction and minimize patient contrast load. 18 The details of that study are beyond the scope of this article; in short, we determined an optimal protocol to be 0.1-mmol/kg Omniscan preload given 6 minutes before DSC acquisition.…”

Section: Discussionmentioning

confidence: 99%

Relative Cerebral Blood Volume Values to Differentiate High-Grade Glioma Recurrence from Posttreatment Radiation Effect: Direct Correlation between Image-Guided Tissue Histopathology and Localized Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Measurements

Baxter

Smith

et al. 2008

AJNR Am J Neuroradiol

363

272

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BACKGROUND AND PURPOSE:Differentiating tumor growth from posttreatment radiation effect (PTRE) remains a common problem in neuro-oncology practice. To our knowledge, useful threshold relative cerebral blood volume (rCBV) values that accurately distinguish the 2 entities do not exist. Our prospective study uses image-guided neuronavigation during surgical resection of MR imaging lesions to correlate directly specimen histopathology with localized dynamic susceptibility-weighted contrastenhanced perfusion MR imaging (DSC) measurements and to establish accurate rCBV threshold values, which differentiate PTRE from tumor recurrence.

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Section: Discussionmentioning

confidence: 99%

Relative Cerebral Blood Volume Values to Differentiate High-Grade Glioma Recurrence from Posttreatment Radiation Effect: Direct Correlation between Image-Guided Tissue Histopathology and Localized Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Measurements

Baxter

Smith

et al. 2008

AJNR Am J Neuroradiol

363

272

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“…This dosage, at high field strength, provides strong signal intensity to noise while minimizing patient contrast load. 33 …”

Section: Preoperative Dsc-mr Imaging Protocolmentioning

confidence: 99%

“…DSC-MR imaging coregistration enabled region-of-interest placement for rCBV calculation within previously recorded stereotactic locations of corresponding surgical tissue specimens, as previously described. [33][34][35] All regions of interest were also inspected to ensure exclusion of visible large vessels.…”

Section: Coregistration Of Stereotactic and Dsc-mr Imaging Datasetsmentioning

confidence: 99%

Correlations between Perfusion MR Imaging Cerebral Blood Volume, Microvessel Quantification, and Clinical Outcome Using Stereotactic Analysis in Recurrent High-Grade Glioma

Eschbacher

Dueck

et al. 2011

AJNR Am J Neuroradiol

115

125

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BACKGROUND AND PURPOSE:Quantifying MVA rather than MVD provides better correlation with survival in HGG. This is attributed to a specific "glomeruloid" vascular pattern, which is better characterized by vessel area than number. Despite its prognostic value, MVA quantification is laborious and clinically impractical. The DSC-MR imaging measure of rCBV offers the advantages of speed and convenience to overcome these limitations; however, clinical use of this technique depends on establishing accurate correlations between rCBV, MVA, and MVD, particularly in the setting of heterogeneous vascular size inherent to human HGG.

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“…The DSC-MRI sequence was a 3D PRESTO acquisition (effective TE ϭ 30 ms, TR ϭ 20 ms, 48 [first visit of patient] or 30 [second visit] slices, dynamic resolution 1.5 sec, SENSE factor 2.5) and 15 mL of contrast agent (Magnevist, Schering, Germany) was injected at a rate of 5 mL/sec followed by a chaser of 25 mL saline, also injected at 5 mL/sec (14,15).…”

Section: Mr Protocolmentioning

confidence: 99%

Can arterial spin labeling detect white matter perfusion signal?

Osch

Teeuwisse

Walderveen

et al. 2009

Magnetic Resonance in Med

190

194

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Since the invention of arterial spin labeling (ASL) it has been acknowledged that ASL does not allow reliable detection of a white matter (WM) perfusion signal. However, recent developments such as pseudo-continuous labeling and background suppression have improved the quality. The goal of this research was to study the ability of these newer ASL sequences to detect WM perfusion signal. Background suppressed pseudo-continuous ASL was implemented at 3T with multislice 2D readout after 1525 ms. In five volunteers it was shown that 10 min scanning resulted in significant perfusion signal in 70% of WM voxels. Increasing the labeling and delay time did not lead to a higher percentage. In 27 normal volunteers it was found that 35 averages are necessary to detect significant WM signal, but 150 averages are needed to detect signal in the deep WM. Finally, it was shown in a patient with a cerebral arteriovenous malformation that pseudo-continuous ASL enabled the depiction of hypointense WM perfusion signal, although dynamic susceptibility contrast MRI showed that this region was merely showing delayed arrival of contrast agent than hypoperfusion. It can be concluded that, except within the deep WM, ASL is sensitive enough to detect WM perfusion signal and perfusion deficits. Magn Reson Med 62:165-173, 2009.

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Three-dimensional Dynamic Susceptibility-weighted Perfusion MR Imaging at 3.0 T: Feasibility and Contrast Agent Dose

Abstract: With echo-shifted multishot echo-planar imaging, dynamic susceptibility-weighted perfusion MR imaging at high field strength is feasible without relevant image distortions. Compared with contrast agent dose for 1.5 T imaging, the dose for 3.0 T can be reduced to 0.10 mmol.

Cited by 52 publications

References 48 publications

Relative Cerebral Blood Volume Values to Differentiate High-Grade Glioma Recurrence from Posttreatment Radiation Effect: Direct Correlation between Image-Guided Tissue Histopathology and Localized Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Measurements

Relative Cerebral Blood Volume Values to Differentiate High-Grade Glioma Recurrence from Posttreatment Radiation Effect: Direct Correlation between Image-Guided Tissue Histopathology and Localized Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging Measurements

Correlations between Perfusion MR Imaging Cerebral Blood Volume, Microvessel Quantification, and Clinical Outcome Using Stereotactic Analysis in Recurrent High-Grade Glioma

Can arterial spin labeling detect white matter perfusion signal?

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