Three-dimensional endomicroscopy of the human colon using optical coherence tomography

Adler, Desmond C.; Zhou, Chao; Tsai, Tsung Han; Schmitt, Joe; Huang, Qin; Mashimo, Hiroshi; Fujimoto, James G.

doi:10.1364/oe.17.000784

Cited by 120 publications

(92 citation statements)

References 42 publications

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“…1). This technique has already been applied to other tissues, including retina, 9 airways, 10 cervix uteri, 11 and the gastrointestinal tract; 12 yet, to our knowledge, no study has explored the diagnostic value of 3-D OCT imaging in the evaluation of human cartilage.…”

mentioning

confidence: 99%

Three‐dimensional imaging and analysis of human cartilage degeneration using Optical Coherence Tomography

Nebelung

Brill

Marx

et al. 2015

Journal Orthopaedic Research

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Optical Coherence Tomography (OCT) is an evolving imaging technology allowing non-destructive imaging of cartilage tissue at near-histological resolution. This study investigated the diagnostic value of real time 3-D OCT in comparison to conventional 2-D OCT in the comprehensive grading of human cartilage degeneration. Fifty-three human osteochondral samples were obtained from eight total knee arthroplasties. OCT imaging was performed by either obtaining a single two-dimensional cross-sectional image (2-D OCT) or by collecting 100 consecutive parallel 2-D OCT images to generate a volumetric data set of 8 Â 8 mm (3-D OCT). OCT images were assessed qualitatively according to a modified version of the DJD classification and quantitatively by algorithm-based evaluation of surface irregularity, tissue homogeneity, and signal attenuation. Samples were graded according to the Outerbridge classification and statistically analyzed by one-way ANOVA, Kruskal Wallis and Tukey's or Dunn's post-hoc tests. Overall, the generation of 3-D volumetric datasets and their multiple reconstructions such as rendering, surface topography, parametric, and cross-sectional views proved to be of potential diagnostic value. With increasing distance to the mid-sagittal plane and increasing degeneration, score deviations increased, too. In conclusion, 3-D imaging of cartilage with image analysis algorithms adds considerable potential diagnostic value to conventional OCT diagnostics. ß

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mentioning

confidence: 99%

Three‐dimensional imaging and analysis of human cartilage degeneration using Optical Coherence Tomography

Nebelung

Brill

Marx

et al. 2015

Journal Orthopaedic Research

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“…In all of these studies, OCT analyses were performed based on two-dimensional OCT images. Three-dimensional reconstruction of the ulcerative colitis section was presented by Adler et al showing en face image that emphasized presence of large subsurface voids and ulcerations, and absence of regular crypt pattern [152]. Biliary/pancreatic tract: The main application for microscopic imaging of the bile duct is to identify the nature of bile duct strictures, which may be primary cancer (cholangiocarcinoma), metastatic cancer, primary sclerosing cholangitis, primary biliary cirrhosis, or other inflammation caused by the like of biliary stones.…”

Section: Gastrointestinal Tractmentioning

confidence: 99%

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Gora¹,

Suter²,

Tearney³

et al. 2017

Biomed. Opt. Express

262

203

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Abstract:In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forwardviewing probes, along with different scanning mechanisms (proximal-scanning versus distalscanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic OCT is also discussed. References and links 1. T. Cao and H. L. Tey, "High-definition optical coherence tomography -an aid to clinical practice and research in dermatology," J. Dtsch. Dermatol. Ges. 13(9), 886-890 (2015). 2. J. Olsen, L. Themstrup, and G. B. Jemec, "Optical coherence tomography in dermatology," G. Ital. Dermatol.Venereol. 150(5), 603-615 (2015). 3. M. Ulrich, L. Themstrup, N. de Carvalho, M. Manfredi, C. Grana, S. Ciardo, R. Kästle, J. Holmes, R.Whitehead, G. B. Jemec, G. Pellacani, and J. Welzel, "Dynamic Optical Coherence Tomography in Dermatology," Dermatology (Basel) 232(3), 298-311 (2016). 4. G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21(7), 543-545 (1996). 5. A. M. Rollins, R. Ung-Arunyawee, A. Chak, R. C. K. Wong, K. Kobayashi, M. V. Sivak, Jr., and J. A. Izatt, "Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design," Opt. Lett. 24(19), 1358-1360 (1999). 6. M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A.Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51(4), 474-479 (2000). 7. J. Xi, A. Zhang, Z. Liu, W. Liang, L. Y. Lin, S. Yu, and X. Li, "Diffractive catheter for ultrahigh-resolution spectral-domain volumetric OCT imaging," Opt. Lett. 39(7), 2016-2019 (2014). 8. P. H. Tran, D. S. Mukai, M. Brenner, and Z. Chen, "In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probe," Opt. Lett. 29(11), 1236-1238 (2004). Goodnow, and C. Petersen, "Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography," Opt. Lett. 29(19), 2261-2263 (2004). 10. T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H.Mashimo, A. E. Cable, and J. G. Fujimoto, "Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology," Biomed. Opt. Express 4(7), 1119-11...

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“…During the early development of SD-OCT methods in ophthalmology, the en-face view was reinstated in the form of an approximate fundus image, useful in guiding the B-scanning investigation [15,16]. Continuous increase in speed of the SD-OCT methods has led to reduction of the time to produce a software cut en-face OCT image.…”

Section: Introductionmentioning

confidence: 99%

Imaging the eye fundus with real-time en-face spectral domain optical coherence tomography

Bradu

Podoleanu

2014

Biomed. Opt. Express

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Real-time display of processed en-face spectral domain optical coherence tomography (SD-OCT) images is important for diagnosis. However, due to many steps of data processing requirements, such as Fast Fourier transformation (FFT), data re-sampling, spectral shaping, apodization, zero padding, followed by software cut of the 3D volume acquired to produce an en-face slice, conventional high-speed SD-OCT cannot render an en-face OCT image in real time. Recently we demonstrated a Master/Slave (MS)-OCT method that is highly parallelizable, as it provides reflectivity values of points at depth within an A-scan in parallel. This allows direct production of en-face images. In addition, the MS-OCT method does not require data linearization, which further simplifies the processing. The computation in our previous paper was however time consuming. In this paper we present an optimized algorithm that can be used to provide en-face MS-OCT images much quicker. Using such an algorithm we demonstrate around 10 times faster production of sets of en-face OCT images than previously obtained as well as simultaneous real-time display of up to 4 en-face OCT images of 200 × 200 pixels 2 from the fovea and the optic nerve of a volunteer. We also demonstrate 3D and B-scan OCT images obtained from sets of MS-OCT Cscans, i.e. with no FFT and no intermediate step of generation of A-scans.

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Three-dimensional endomicroscopy of the human colon using optical coherence tomography

Cited by 120 publications

References 42 publications

Three‐dimensional imaging and analysis of human cartilage degeneration using Optical Coherence Tomography

Three‐dimensional imaging and analysis of human cartilage degeneration using Optical Coherence Tomography

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Imaging the eye fundus with real-time en-face spectral domain optical coherence tomography

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