2013
DOI: 10.1038/jid.2013.60
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Three-Dimensional Morphology of Touch Domes in Human Hairy Skin by Correlative Light and Scanning Electron Microscopy

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Cited by 17 publications
(17 citation statements)
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“…These cases have led to the suggestion that this subset of NEC may be analogous to primary cutaneous NEC, a lesion also referred to as MCC because of its presumed relationship to the Merkel cell. The Merkel cell is an endocrine‐like cell with distinctive ultrastructural attributes that expresses endocrine peptides and, characteristically, keratin 20 . In the skin, these cells are distributed either singly or in clusters with the epidermis, the latter often near hair follicles, where they form interactions with sensory neurites that penetrate into the epidermis.…”
Section: Primary Nonepithelial and Specialized Epithelial Tumors Of Ementioning
confidence: 99%
See 1 more Smart Citation
“…These cases have led to the suggestion that this subset of NEC may be analogous to primary cutaneous NEC, a lesion also referred to as MCC because of its presumed relationship to the Merkel cell. The Merkel cell is an endocrine‐like cell with distinctive ultrastructural attributes that expresses endocrine peptides and, characteristically, keratin 20 . In the skin, these cells are distributed either singly or in clusters with the epidermis, the latter often near hair follicles, where they form interactions with sensory neurites that penetrate into the epidermis.…”
Section: Primary Nonepithelial and Specialized Epithelial Tumors Of Ementioning
confidence: 99%
“…In the skin, these cells are distributed either singly or in clusters with the epidermis, the latter often near hair follicles, where they form interactions with sensory neurites that penetrate into the epidermis. These disc‐like collections of Merkel cells and neural elements, referred to “Haarscheiben” or “touch domes,” are thought to be involved in mechanoreceptive sensory touch . How these postmitotic endocrine cells might contribute to cutaneous neoplasia is uncertain, though it is likely, as in the esophagus and other sites, that MCC shares a common progenitor cell with other local forms of epithelial neoplasia, though the Merkel‐like pathway in skin is now known to be associated with a unique MCC‐associated polyomavirus .…”
Section: Primary Nonepithelial and Specialized Epithelial Tumors Of Ementioning
confidence: 99%
“…SEM is a noninvasive technique which can be used for micro- and nanoscale observation and the characterization of inorganic or organic solids (revealing the microstructure, morphology, and fracture topography) [5,15,16,17], while the SEM technique can be used for the investigation of cells [18], tissues [5,14,19,20], fragments of organs, or even organisms of suitable size [21,22]. …”
Section: Introductionmentioning
confidence: 99%
“…In the adult mouse, Merkel cell clusters are polarized to the caudal side of tylotrich hairs and this polar organization has recently been shown to require Frizzled6 signaling (Chang and Nathans 2013). In human skin, TDs are most abundant on the trunk and about half are associated with hair follicles (Orime et al 2013). Histological studies suggest that human TDs are innervated by multiple types of sensory afferents (Reinisch and Tschachler 2005).…”
mentioning
confidence: 99%
“…Histological studies suggest that human TDs are innervated by multiple types of sensory afferents (Reinisch and Tschachler 2005). A recent study found that human TDs range in diameter from 50 to 500 mm and contain 65-265 Merkel cells (Orime et al 2013). In adult mice, TDs are somewhat smaller, containing 5-40 Merkel cells in a cluster 100 mm in diameter (Lumpkin et al 2003;Lesko et al 2013).…”
mentioning
confidence: 99%