Three-dimensional printing of surgical anatomy

Powers, Mary K.; Lee, Benjamin R.; Silberstein, Jonathan L.

doi:10.1097/mou.0000000000000274

Cited by 35 publications

(22 citation statements)

References 22 publications

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“…[5][6][7] In addition, bioprinting, which involves the placement of cells, proteins and genes on a substrate, is also being conducted in the anticipation of future applications in tissue engineering. 8,9) Future artificial organs and implantable devices are also being designed.…”

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confidence: 99%

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

Tagami

Fukushige

Ogawa

et al. 2017

Biological & Pharmaceutical Bulletin

119

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Three-dimensional (3D) printers have been applied in many fields, including engineering and the medical sciences. In the pharmaceutical field, approval of the first 3D-printed tablet by the U.S. Food and Drug Administration in 2015 has attracted interest in the manufacture of tablets and drugs by 3D printing techniques as a means of delivering tailor-made drugs in the future. In current study, polyvinylalcohol (PVA)-based tablets were prepared using a fused-deposition-modeling-type 3D printer and the effect of 3D printing conditions on tablet production was investigated. Curcumin, a model drug/fluorescent marker, was loaded into PVA-filament. We found that several printing parameters, such as the rate of extruding PVA (flow rate), can affect the formability of the resulting PVA-tablets. The 3D-printing temperature is controlled by heating the print nozzle and was shown to affect the color of the tablets and their curcumin content. PVA-based infilled tablets with different densities were prepared by changing the fill density as a printing parameter. Tablets with lower fill density floated in an aqueous solution and their curcumin content tended to dissolve faster. These findings will be useful in developing drug-loaded PVA-based 3D objects and other polymerbased articles prepared using fused-deposition-modeling-type 3D printers. Key words three-dimensional (3D) printing; fused deposition modeling; polyvinylalcohol (PVA); tablet; curcuminThe production of various objects by three-dimensional (3D) printers has developed extensively as the printers have evolved.1,2) 3D printers are used by the creator to rapidly design prototype parts and can thus considerably cut production times and costs. 3D printers have been used to manufacture parts for cars, home electronic devices, aircraft engines, buildings, and for other practical uses. It is speculated that 3D printers have potential for many applications and that the 3D printer market will expand.The medical applications of 3D printers have been expanding and bringing innovation to the field.3) For example, the 3D printing of organs and body parts is used to provide blueprints 4) for surgeons and patients to understand disease sites.5-7) In addition, bioprinting, which involves the placement of cells, proteins and genes on a substrate, is also being conducted in the anticipation of future applications in tissue engineering.8,9) Future artificial organs and implantable devices are also being designed. 10,11) In the pharmaceutical industry, a new tablet (SPRITAM ® , a rapid disintegrating tablet containing levetiracetam) prepared by 3D printing was approved by the U.S. Food and Drug Administration (FDA) in 2015.12) The application of 3D printing in medicine, including tablets, holds promise for made-to-order drugs and removes mass product manufacturing from the production line, although the technology in pharmaceutical industry is still in infancy.13) Moreover, it is predicted that the internet of things (IoT) will increase the future use of 3D printers by reinforcing man...

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mentioning

confidence: 99%

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

Tagami

Fukushige

Ogawa

et al. 2017

Biological & Pharmaceutical Bulletin

119

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“…A 3Dp model however, can provide a multi-sensory learning experience. Highly accurate bone (AbouHashem et al, 2015), kidney (Knoedler et al, 2015;Powers et al, 2016), lung, liver and breast tumours have been printed. Such models are complemented by contrast CT, which can present surrounding vasculature and 'negative' structures such as air sinuses.…”

Section: Introductionmentioning

confidence: 99%

“…However, surgical specialties would most likely become a primary source of educational models, as those created for pre-operative planning can be re-used in the classroom (Bizzotto et al, 2015). A variety of 3D-printed models have been produced by numerous specialties (Marro et al, 2016), ranging from comminuted distal tibial fractures (Chung et al, 2015) to pulmonary vasculature (Kurenov et al, 2015) and the renal system (Powers et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The role of 3D printing in anatomy education and surgical training: A narrative review

Li¹,

Kui²,

Lee³

et al. 2017

MedEdPublish

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Recent expansions in the development and availability of three-dimensional printing (3Dp) have led to the uptake of this valuable and effective technology within the modern context of medical education. It is proposed that 3Dp is entirely appropriate for the creation of anatomical models for purposes of teaching and training due to the ability of this technology to produce accurate 3D physical representations based on a processed data set acquired from sources including magnetic resonance imaging (MRI) and computed tomography (CT). When investigating the currently available educational research with respect to 3Dp, it is important that the best evidence supporting the practical and theoretical benefits of this technology in teaching and training can be identified, while any obstacles to the effective implementation of 3Dp can also be determined. Here, literature describing recent primary research with respect to the capability and utility of 3Dp in anatomy and surgery have been explored in a narrative review. The impact on resources of implementing this technology within medical education have also been investigated. In order to emphasise wider applications in medicine, the role of 3Dp in medical practice and research have also been examined. To identify recent literature appropriate for this review published up to March 2017, suitable search terms were determined and applied using PubMed and results were judged against an established checklist. The research identified was then allocated with respect to the agreed topic areas of anatomy education, surgical training, medical usage and medical research. A student partnership approach was utilised for this review and the focus of the work was driven by undergraduate students in collaboration with anatomy and medical educators. Preliminary findings from this narrative review support the implementation of 3Dp in anatomy education and surgical training as a supplement to traditional learning approaches.

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“…The recent broad application of three-dimensional printing (3D printing) technology has demonstrated its value in clinical medication: 3D printed patient-specific organ models have helped clinicians to rehearse or better design surgeries [6,7], and some 3D printed biomaterials have been implanted into patients to facilitate selfregeneration of impaired tissue/organ [8,9]. Moreover, 3D printing offers a feasible way to manufacture bioartificial organs stereoscopically, which could in theory be able to produce organs with in vivo-like biofunctions.…”

Section: Introductionmentioning

confidence: 99%

Current progresses of 3D bioprinting based tissue engineering

Zhang

Wang

2017

Quant. Biol.

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Background: The shortage of available organs for transplantation is the major obstacle hindering the application of regenerative medicine, and has also become the desperate problem faced by more and more patients nowadays. The recent development and application of 3D printing technique in biological research (bioprinting) has revolutionized the tissue engineering methods, and become a promising solution for tissue regeneration. Results: In this review, we summarize the current application of bioprinting in producing tissues and organoids, and discuss the future directions and challenges of 3D bioprinting. Conclusions: Currently, 3D bioprinting is capable to generate patient-specialized bone, cartilage, blood vascular network, hepatic unit and other simple components/tissues, yet pure cell-based functional organs are still desired.

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Three-dimensional printing of surgical anatomy

Abstract: Three-dimensional printing in the field of medicine is growing quickly, and will soon be incorporated into the way residents are taught and patients are educated. For surgical simulation in a variety of disease processes, this will be particularly useful for urologic surgery.

Cited by 35 publications

References 22 publications

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

3D Printing Factors Important for the Fabrication of Polyvinylalcohol Filament-Based Tablets

The role of 3D printing in anatomy education and surgical training: A narrative review

Current progresses of 3D bioprinting based tissue engineering

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