2020
DOI: 10.1039/d0nr03071f
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Three-dimensional rope-like and cloud-like nanofibrous scaffolds facilitating in-depth cell infiltration developed using a highly conductive electrospinning system

Abstract: Three-dimensional (3D) nanofibrous scaffolds are at the forefront of tissue engineering research. However, owing to the compact geometries or unstable reserved pores, the scaffolds produced by the current techniques provide...

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Cited by 8 publications
(8 citation statements)
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“…Interestingly, incorporating Y(NO 3 ) 3 ·6H 2 O into the spinning solution resulted in a 3D regime (Figure D; SI, Movie S3). In this 3D case, jet bending occurred closer to the nozzle because the solution with higher electrical conductivity has stronger Coulomb force that enhances the instability. , The solution jets developed spirals not only vertically to the nozzle but also parallel to the electric field, which is mainly attributed to the charge redistribution. , Figure E schematically illustrates the proposed interaction between fiber and the electric field. The fiber segment (gray) carries excessive positive charges from the metal nozzle (red “+”), which dissipate into the environment.…”
Section: Results and Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Interestingly, incorporating Y(NO 3 ) 3 ·6H 2 O into the spinning solution resulted in a 3D regime (Figure D; SI, Movie S3). In this 3D case, jet bending occurred closer to the nozzle because the solution with higher electrical conductivity has stronger Coulomb force that enhances the instability. , The solution jets developed spirals not only vertically to the nozzle but also parallel to the electric field, which is mainly attributed to the charge redistribution. , Figure E schematically illustrates the proposed interaction between fiber and the electric field. The fiber segment (gray) carries excessive positive charges from the metal nozzle (red “+”), which dissipate into the environment.…”
Section: Results and Discussionmentioning
confidence: 99%
“… 3 , 35 The solution jets developed spirals not only vertically to the nozzle but also parallel to the electric field, which is mainly attributed to the charge redistribution. 21 , 36 Figure 2 E schematically illustrates the proposed interaction between fiber and the electric field. The fiber segment (gray) carries excessive positive charges from the metal nozzle (red “+”), which dissipate into the environment.…”
Section: Results and Discussionmentioning
confidence: 99%
“…During the conjugate electrospinning, once the surface tension of the charged droplet is overcome by the electrostatic forces, it becomes nanofiber jets and be ejected along a straight path for a certain distance. [20] As nanofiber jets accelerate in the electric field, positively and negatively charged nanofibers from opposite sides attract each other during the initial stage (Figure 1A). Subsequently, entangled nanofibers were attracted to the grounded metal funnel [33] (Figure 1B).…”
Section: Discussionmentioning
confidence: 99%
“…Li et al developed a 3D electrospinning technique to create 3D rope-like or cloud-like nanofibrous scaffolds. [20] The formation of loose 3D rope-like and 3D cloudlike bulks is due to the addition of silver nanoparticles (Ag NPs) endowed spinning solutions with high conductivities. But, the introduction of Ag NPs limits the application of sponges in the fields of biomaterials and tissue engineering.…”
Section: Introductionmentioning
confidence: 99%
“…Conventionally, multiple jets continuously deposit nanofibers closely on top of each other on the collector in a random fashion to form a dense scaffold . This in turn increases the mechanical strength of the scaffold, but it becomes less permeable to cells with growth only on the superficial layer that usually acts as a 2D scaffold. , The packing density of a scaffold can be decreased by increasing the collector’s distance from the needle tip and the diameter of the needle. This widens the fiber deposition area of the jets on the collector and enlarges the gap between the larger diameter fibers in the scaffold .…”
Section: Introductionmentioning
confidence: 99%