Three novel β3 domain-deletion peptides for the sensitive and specific detection of HPA-4 and six low frequency β3-HPA antibodies

Summary Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the pathogenesis, clinical presentation, laboratory diagnosis and prenatal and post-natal management of NAIT and highlight areas of controversy that deserve the attention of clinical and laboratory investigators.

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Establishment of a cell line panel as an alternative source of platelet antigens for a screening assay of anti‐human platelet antibodies

Hayashi

Amakishi

Matsuyama

et al. 2011

Transfusion Medicine

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Three novel β3 domain-deletion peptides for the sensitive and specific detection of HPA-4 and six low frequency β3-HPA antibodies

Abstract: These data demonstrate that beta3 integrin domain-deletion fragments are suitable molecular targets for HPA antibody detection.

Cited by 13 publications

References 43 publications

Application of lyophilised human platelets for antibody detection in solid phase red cell adherence assay

Application of lyophilised human platelets for antibody detection in solid phase red cell adherence assay

Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management

Establishment of a cell line panel as an alternative source of platelet antigens for a screening assay of anti‐human platelet antibodies

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