“…Recently, non-oxidizing biocides including 2,2-dibromo-3-nitrilopropionamide (DBNPA), isothiazolone, and glutaraldehyde have generated attention as alternative chemicals that are directly applicable to RO elements without the risk of damage to RO membranes due to their membrane compatibility [8,[16][17][18]. Unlike chlorine-based chemicals, non-oxidizing biocides possess specific modes of action in inactivating microorganisms.…”