Thrombelastographische Studien bei Fr�hgeborenen im ersten Lebensmonat

Fibrinolytic Activity, Thrombin Inhibitor and Kinetics of Clot Formation in Premature Infants with Respiratory Distress Syndrome

“…As compared with adults, the structural abnormality would indicate A deficient platelet function. Suggestive evidence of such abnormal platelet function in the presence of a normal thrombelastogram has been claimed by one investigator of premature infants [19]. Abnormal thrombelastograms similar to ours and indicative of abnormal platelet function have been presented by others for the first ten days of life in infants born at the seventh and eighth month of gestation [ : ' I .…”

“…Such observation then would tend to confirm the hypercoagulability of the blood from the umbilical vein as observed in prematures at the seventh month of gestation [l] or with the thrombelastogram in infants born a t term [21]. A tendency t o hypercoagulability was also ohserved with the thrombelastogram in prematures without RDS during the first ten days of life; other thrombelastograms of the reported series were normal [19]. Besides the earlier onset of clotting as observed in our series of premature infants, the structure of the clot on the other hand, was quite defective as compared with clots obtained from adult plasma.…”

Changes in Fibrin-stabilizing Factor Levels in Relation to Maternal Hemorrhage and Neonatal Disease

“…Although most clotting factors are low at birth, an increased clotting tendency has been reported to occur in the blood of normal newborns [8], as well as in newborns with RDS [16,22,24,34,42]. KUNZER [25] noted that clots from cord blood have an increased resistance to fibrinolysis compared with those from older children, and attributed this difference to the existence of a special 'fetal' fibrinogen.…”