Thrombocytopenia in Experimental Trypanosomiasis

Davis, Charles E.; Robbins, Robert S.; Weller, Richard D.; Braude, Abraham I.

doi:10.1172/jci107684

Cited by 39 publications

(11 citation statements)

References 18 publications

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“…The formation of platelet aggregations has been histologically shown in T. vivax infections (Murray and Dexter, 1988) and Trypanosoma rhodesiense (Davis et al . 1974), which indicates a consumptive loss of thrombocytes. These platelet aggregations are thought to be due to antibodies directed against platelets (Assoku and Gardiner, 1989).…”

Section: Discussionmentioning

confidence: 99%

The impact of co-infections on the haematological profile of East African Short-horn Zebu calves

et al. 2013

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SUMMARYThe cumulative effect of co-infections between pathogen pairs on the haematological response of East African Short-horn Zebu calves is described. Using a longitudinal study design a stratified clustered random sample of newborn calves were recruited into the Infectious Diseases of East African Livestock (IDEAL) study and monitored at 5-weekly intervals until 51 weeks of age. At each visit samples were collected and analysed to determine the infection status of each calf as well as their haematological response. The haematological parameters investigated included packed cell volume (PCV), white blood cell count (WBC) and platelet count (Plt). The pathogens of interest included tick-borne protozoa and rickettsias, trypanosomes and intestinal parasites. Generalized additive mixed-effect models were used to model the infectious status of pathogens against each haematological parameter, including significant interactions between pathogens. These models were further used to predict the cumulative effect of co-infecting pathogen pairs on each haematological parameter. The most significant decrease in PCV was found with co-infections of trypanosomes and strongyles. Strongyle infections also resulted in a significant decrease in WBC at a high infectious load. Trypanosomes were the major cause of thrombocytopenia. Platelet counts were also affected by interactions between tick-borne pathogens. Interactions between concomitant pathogens were found to complicate the prognosis and clinical presentation of infected calves and should be taken into consideration in any study that investigates disease under field conditions.

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Section: Discussionmentioning

confidence: 99%

The impact of co-infections on the haematological profile of East African Short-horn Zebu calves

et al. 2013

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“…Intact trypanosomes or fragments of trypanosomes may cause platelet aggregation commonly called microangiopathy (Davies et al, 1974). This can lead to the release of platelet autoantibodies that in turn releases procoagulants and thereby causing fibrin deposits.…”

Section: Anaemia Through Platelet Aggregation (Microangiopathy)mentioning

confidence: 99%

The Mechanisms of Anaemia in Trypanosomosis: A Review

Mbaya¹,

Kumshe²,

Nwosu³

2012

Anemia

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“…1973). Evidence for activation of the coagulation system accompanied or not by disseminated intravascular coagulation (DIC) has since been reported, based on observations of increased fibrin degradation products, increased blood viscosity, increased clotting times, thrombocytopenia, and decreased coagulation factors in the plasma of man, monkeys, cattle, rabbits or rats infected with African trypanosomes (Sadun et al 1973, Davis et al 1974, Robins-Browne, Schneider & Metz 1975, Greenwood & Whittle 1976, Wellde et al 1978, Forsberg et al 1979, Davis 1982. In the present study we have demonstrated that coagulation abnormalities also occur in the mouse model, based on increased plasma clotting time during infection with T. brucei.…”

Section: Discussionmentioning

confidence: 99%

Macrophage procoagulant activity in experimental African trypanosomiasis

Rossi

Dean

Terry

1987

Parasite Immunology

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Peritoneal macrophages from mice infected with Trypanosoma brucei brucei expressed a greatly elevated procoagulant activity (PCA) which could be reversed to normal levels after trypanocidal therapy. Comparison with infection caused by the non-pathogenic T. musculi suggested that the level of PCA related to parasite pathogenicity. Unstimulated macrophages, which generate only slight PCA upon stimulation with zymosan, become hyperresponsive to this stimulus during the course of infection. Hyperresponsiveness is not a generalized feature of these cells during infection, as they become progressively hyporesponsive to the same stimulus in terms of lysosomal enzyme secretion. We were unable to demonstrate a direct role of the trypanosomes in macrophage activation; however, artificial removal of the glycoprotein coat rendered the parasites highly stimulatory for macrophages even in the absence of opsonins. These results suggest that the parasites may activate macrophages indirectly, and that the resulting elevated PCA may play a role in the abnormal blood coagulation known to occur in this disease.

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Thrombocytopenia in Experimental Trypanosomiasis

Cited by 39 publications

References 18 publications

The impact of co-infections on the haematological profile of East African Short-horn Zebu calves

The impact of co-infections on the haematological profile of East African Short-horn Zebu calves

The Mechanisms of Anaemia in Trypanosomosis: A Review

Macrophage procoagulant activity in experimental African trypanosomiasis

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