Thrombogenicity of an Elastomer-Coated Aortofemoral Dacron Prosthetic Graft in Humans

Becquemin, Jean‐Pierre; Haiduc, Franck; Cavillon, A

doi:10.1007/bf02133064

Cited by 15 publications

(7 citation statements)

References 15 publications

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“…Surface modifications involving albumin, 25,26 collagen, [26][27][28] polymers, [29][30][31][32] endothelial cells, 7,33,34 autologous tissue seeding, 35,36 and localized delivery of antithrombotic agents [37][38][39] have not resulted in increased long-term patency rates of such grafts in clinical applications. However, recent research involving the mechanism of thrombosis formation has suggested that NO may be crucial for the prevention of thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Incorporation of nitric oxide-releasing crosslinked polyethyleneimine microspheres into vascular grafts

Pulfer

Ott

Smith

1997

J. Biomed. Mater. Res.

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Over the years, many attempts have been made to increase the patency of small- to medium-sized prosthetic vascular grafts. However, none of them has greatly affected long-term rates. Recently, nitric oxide (NO) has been shown to inhibit thrombus formation in such grafts, suggesting that local delivery of NO may help to increase graft patency. This study describes the site-specific delivery of NO by entrapping NO-releasing microspheres in the pores of a vascular graft. NO-releasing polyethyleneimine microspheres (PEIX) were developed using a novel water-in-oil emulsion technique involving chemical crosslinking with a bis-epoxide. The PEIX microspheres were then derivatized with NO forming the [N(O)NO]- moiety of the diazeniumdiolates formerly known as NONOates. These polymeric NO-releasing particles were found to spontaneously release 194 nmol NO/mg with a half-life of over 66 h under physiologic conditions. Fluorescein isothiocyanate-labeled microspheres were then embedded into the pores of a 60-micron nonreinforced Gore-tex vascular graft using a simple evacuation technique and evaluated for microsphere placement and NO release. Scanning electron microscopic analysis showed the microspheres entrapped in the pores of the vascular graft releasing 10 nmol NO/mg with a half-life of 51 h. The microspheres remained entrapped in the graft even after immersion and NO release, as confirmed by fluorescence of the medium. These results suggest that NO-releasing particles can be incorporated into the pores of a vascular graft to deliver therapeutic amounts of NO for the prevention of thrombosis in small-diameter prosthetic grafts.

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Section: Discussionmentioning

confidence: 99%

Incorporation of nitric oxide-releasing crosslinked polyethyleneimine microspheres into vascular grafts

Pulfer

Ott

Smith

1997

J. Biomed. Mater. Res.

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“…The porosity of commercially available polyester (Dacron) knitted vascular grafts can be reduced by coating or sealing with a novel ionic urethane, to improve their blood-proof property. The mechanical properties of coated vascular grafts have been found to be comparable with, or superior to, the pre-coated Dacron substrate [23][24][25][26][27][28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 95%

Small diameter Polyurethane vascular graft reinforced by elastic weft-knitted tubular fabric of polyester/spandex

Zhou

Ouyang

et al. 2008

Fibers Polym

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Small diameter vascular grafts were fabricated from pure Polyurethane (PU) as well as PU reinforced with a tubular weft-knitted fabric. The tensile properties of the reinforced composite vascular grafts were compared with that of the tubular fabric itself and the pure PU vascular grafts. The elasticity and strength of the reinforced vascular grafts were improved compared with the tubular fabric. Strength of the reinforced vascular grafts was 5-10 times of the strength of the pure PU vascular grafts. Expanding the tubular fabric to increase the inner diameter of the reinforced vascular graft reduced the graft's strength and initial modulus, but the difference was reduced as the PU content was increased. For grafts of the same inner diameter, increasing the PU content increased the thickness and strength of the graft wall, which led to a general increase in the strength and initial modulus of the composite vascular grafts.

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“…Porosity in the vascular grafts wall can be reduced by coating or sealing with a novel ionic urethane, to improve their blood leakproof property. The mechanical properties of coated vascular grafts have been found to be comparable or superior to the precoated Dacron substrate 23–33…”

Section: Introductionmentioning

confidence: 98%

Synergetic behavior of low T_g polybutadiene polymers and polysiloxanes as components for glass fiber sizing in composite materials

Danner

Dey

McAllister

et al. 2010

J of Applied Polymer Sci

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The effect of low T g polybutadiene (PBD) rubbery polymer as a part of polysiloxane/PBD E-glass fibers sizing on mechanical properties of a corresponding epoxy composite material has been evaluated by the punch shear test technique. The results show that the use of hydroxyl terminated PBD led to significant increase in interface shear strength, energy absorption, as well as dynamic modulus and T g in a corresponding composite material. The sizing composition and fiber morphology were characterized by FTIR spectroscopy and AFM microscopy, respectively. Possible rational for such sizing composition/material property relationship is discussed.

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Thrombogenicity of an Elastomer-Coated Aortofemoral Dacron Prosthetic Graft in Humans

Cited by 15 publications

References 15 publications

Incorporation of nitric oxide-releasing crosslinked polyethyleneimine microspheres into vascular grafts

Incorporation of nitric oxide-releasing crosslinked polyethyleneimine microspheres into vascular grafts

Small diameter Polyurethane vascular graft reinforced by elastic weft-knitted tubular fabric of polyester/spandex

Synergetic behavior of low T_g polybutadiene polymers and polysiloxanes as components for glass fiber sizing in composite materials

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Thrombogenicity of an Elastomer-Coated Aortofemoral Dacron Prosthetic Graft in Humans

Cited by 15 publications

References 15 publications

Incorporation of nitric oxide-releasing crosslinked polyethyleneimine microspheres into vascular grafts

Incorporation of nitric oxide-releasing crosslinked polyethyleneimine microspheres into vascular grafts

Small diameter Polyurethane vascular graft reinforced by elastic weft-knitted tubular fabric of polyester/spandex

Synergetic behavior of low Tg polybutadiene polymers and polysiloxanes as components for glass fiber sizing in composite materials

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Product

Resources

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Synergetic behavior of low T_g polybutadiene polymers and polysiloxanes as components for glass fiber sizing in composite materials