Thrombogenicity of Dialyzer Membranes as Assessed by Residual Blood Volume and Surface Morphology at Different Heparin Dosages

Activated Clotting Time Is Not a Sensitive Parameter to Monitor Anticoagulation with Low Molecular Weight Heparin in Hemodialysis

“…These data and the results from the anti-Xa activity mea surements suggest that Hemophan filters might require slightly higher doses of LMWH than polysulfone filters. These findings go well along with those of Debrand-Passard et al [14], These authors assessed the thrombogcnicity of different dialyzer materials by residual blood volume and surface morphology at different heparin dosages and found that polysulfone filters required much smaller dos ages than other dialyzer materials.…”

Clinical Consequences of Blood Flow-Dialyzer Membrane Interactions in Acute Renal Failure

“…thromboxane and platelet factor 4 and other highly reactive products. Platelet activa tion interacts with the activated clotting system [31]. In general, there is limited but consistent information suggesting that cuprophane mem branes tend to activate platelets to a greater extent than some synthetic ones such as PAN.…”

“…However, there is little information on the ability of differ ent membranes to activate the coagulation cas cade. Therefore, the clinical importance of mem brane material in terms of thrombogenicity is uncertain [31][32][33].…”