Thrombolytic Properties of Leukocytes from Peripheral Blood in Healthy Subjects and in Patients with Acute Cerebral Ischemia

Lichy, Christoph; Wagner, Simone; Hacke, Werner; Grau, Armin J.

doi:10.1016/s0049-3848(99)00218-2

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…7 It was reported that leukocytes from peripheral blood in patients with acute cerebral ischemia had smaller fibrinolytic capacity than those of control participants in an in vitro fibrinolysis model. 18 However, in the case of a very limited local area, like an occluded vessel, this may not be true. Because there are a considerable number of leukocytes in human thrombus, 10 fibrinolytic enzymes from leukocytes may work by themselves or promote plasmin-dependent fibrinolysis around the thrombus.…”

Section: Discussionmentioning

confidence: 99%

Leukocytes May Have 2 Opposing Effects in Intravenous rtPA Treatment for Ischemic Stroke

Nomura¹,

Naka²,

Wakabayashi

et al. 2012

Clin Appl Thromb Hemost

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We hypothesized that leukocytes have 2 opposing effects on patients with ischemic stroke treated with recombinant tissue plasminogen activator (rtPA). Patients with ischemic stroke treated with rtPA were divided into 2 groups using the peripheral leukocyte count: high leukocyte group (HLG) and low leukocyte group (LLG) and were evaluated with the National Institutes of Health stroke scale (NIHSS) during the first 24 hours. We defined significant improvement (SI) as NIHSS improving by more than 50% from the baseline, and deterioration following improvement (DFI) as the achievement of SI within 24 hours but its subsequent loss at 24 hours. Fifty-three patients were enrolled, and the rate of SI within 24 hours was higher in HLG than in LLG (85.2% vs 42.3%, P = .0011). However, the rate of DFI was significantly higher in HLG than in LLG (29.6% vs 7.7%, P = .0413). We found that leukocytes might have not only deleterious but also beneficial effects in intravenous rtPA treatment.

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Section: Discussionmentioning

confidence: 99%

Leukocytes May Have 2 Opposing Effects in Intravenous rtPA Treatment for Ischemic Stroke

Nomura¹,

Naka²,

Wakabayashi

et al. 2012

Clin Appl Thromb Hemost

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“…UK is a thrombolytic agent commonly used in the clinic, especially in China. 5,6 UK degrades the chemical bond between arginine and conjugates in the molecule by binding to plasminogen in clots, producing fibrinolytic enzymes, which play a role in thrombolysis. 7,8 However, direct and powerful clinical trial evidence to determine the therapeutic effect of rt-PA or UK for intravenous thrombolysis is lacking.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative study of intravenous thrombolysis with rt-PA and urokinase for patients with acute cerebral infarction

Sun

Liu

et al. 2020

J Int Med Res

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Objective Cerebral infarction has a poor prognosis and causes a serious burden on families and society. Recombinant tissue plasminogen activator (rt-PA) and urokinase (UK) are commonly used thrombolytic agents in the clinic. However, direct and powerful clinical trial evidence to determine the therapeutic effect of rt-PA and UK on intravenous thrombolysis is lacking. Methods In this study, 180 patients with acute cerebral infarction were treated with rt-PA or UK. The National Institutes of Health Stroke Scale (NIHSS) scores, Barthel index, bleeding complications, and biomarkers were evaluated. Results No significant differences in NIHSS or Barthel scores were found between the groups. However, UK increased the risk of intracranial haemorrhage compared with rt-PA. rt-PA had increased activity in reducing serum levels of MMP-9 than UK. Conclusion Intravenous thrombolysis with rt-PA and UK in the time window of acute cerebral infarction can achieve similar therapeutic effects, but rt-PA can further reduce the risk of cerebral haemorrhage and is relatively safer than UK.

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The association baseline NIH Stroke Scale score with ABO blood-subtypes in young patients with acute ischemic stroke

Yang¹,

Zhang

Xie

et al. 2014

Atherosclerosis

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Thrombolytic Properties of Leukocytes from Peripheral Blood in Healthy Subjects and in Patients with Acute Cerebral Ischemia

Cited by 4 publications

References 28 publications

Leukocytes May Have 2 Opposing Effects in Intravenous rtPA Treatment for Ischemic Stroke

Leukocytes May Have 2 Opposing Effects in Intravenous rtPA Treatment for Ischemic Stroke

Comparative study of intravenous thrombolysis with rt-PA and urokinase for patients with acute cerebral infarction

The association baseline NIH Stroke Scale score with ABO blood-subtypes in young patients with acute ischemic stroke

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