Thrombophilia and the risk of post‐thrombotic syndrome: retrospective cohort observation

Spiezia, Luca; Campello, Elena; Giolo, Enrico; Villalta, Sabina; Prandoni, Paolo

doi:10.1111/j.1538-7836.2009.03655.x

Cited by 18 publications

(14 citation statements)

References 9 publications

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“…However, available information concerning the relation between thrombophilia and PTS is limited and still controversial. While some authors failed to demonstrate any correlation between thrombophilia and PTS, others suggested a role of inherited thrombophilia and mainly factor V-Leiden mutation in the development of PTS and leg ulcers [46][47][48]. PTS is commonly reported among patients with proximal DVT.…”

Section: Discussionmentioning

confidence: 99%

Pathophysiology of Post-Thrombotic Syndrome: The Effect of Recurrent Venous Thrombosis and Inherited Thrombophilia

Kreidy

2011

ISRN Vascular Medicine

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Post-thrombotic syndrome is an important chronic complication of deep vein thrombosis. This syndrome can be debilitating to patients and has a major economic impact on health care services. The pathophysiology of post-thrombotic syndrome is currently incompletely understood. Because therapeutic options for post-thrombotic syndrome are extremely limited and results are often disappointing, recognizing of the pathophysiology and risk factors of this syndrome is essential to prevent the disabling consequences of this disease. The present paper focuses on risk determinants of post-thrombotic syndrome after deep vein thrombosis. The contribution of recurrent venous thrombosis and inherited thrombophilia to the pathogenesis of this syndrome is reviewed and discussed in details.

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Section: Discussionmentioning

confidence: 99%

Pathophysiology of Post-Thrombotic Syndrome: The Effect of Recurrent Venous Thrombosis and Inherited Thrombophilia

Kreidy

2011

ISRN Vascular Medicine

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“…3,21 Few, however, have assessed the later evolution of patients with thrombophilia. Spiezia et al 22 recently evaluated thrombophilia as a specific risk factor for PTS, finding no difference between thrombophilic patients and nonthrombophilic patients in the development of this syndrome.…”

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confidence: 99%

Long-term clinical and ultrasonographic evaluation of thrombophilic patients with deep venous thrombosis

et al. 2014

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Objective: The purpose of this study was to evaluate the long term clinical and ultrasonographic outcomes of thrombophilic patients with deep venous thrombosis (DVT). Method: Cohort study, retrospective case-control with cross-sectional analysis. Thirty-nine thrombophilic patients and 25 non-thrombophilic patients were assessed 76.3 ± 45.8 months after diagnosis. Demographic and family data were collected, as well as data from clinical and therapeutic progress, and physical and ultrasound examinations of the limbs were performed. Groups were matched for age and gender and the variables studied were compared across groups. Results: Deep venous thrombosis was more frequent in women. The most common thrombophilias were antiphospholipid syndrome and factor V Leiden mutation. There was no difference between groups in terms of the number of pregnancies or miscarriages and the majority of women did not become pregnant after DVT. Non-spontaneous DVT prevailed. Proximal DVT and DVT of the left lower limb were more frequent, and the main risk factor was use of oral contraceptives. All patients were treated with anticoagulation. There was a higher frequency of pulmonary embolism in non-thrombophilic patients. Most patients considered themselves to have a "normal life" after DVT and reported wearing elastic stockings over at least 2 years. Seventy-one percent of patients had CEAP ≥ 3, with no difference between groups. Deep venous reflux was more frequent in thrombophilic patients. Conclusion: There were no significant differences between groups with respect to most of the variables studied, except for a higher frequency of pulmonary embolism in non-thrombophilic patients and greater frequency of deep venous reflux in thrombophilic patients.Keywords: deep vein thrombosis; thrombophilia; postthrombotic syndrome; pulmonary embolism; duplex scan. ResumoObjetivo: A proposta deste estudo foi realizar a avaliação clínica e ultrassonográfica em longo prazo de pacientes com diagnóstico de trombose venosa profunda (TVP), portadores de trombofilia. Método: estudo coorte, caso-controle retrospectivo com análise transversal. Foram estudados 39 pacientes portadores de trombofilia (PT) e 25 pacientes não portadores de trombofilia (PNT), dentro de um intervalo de tempo de 76,3 ± 45,8 meses, após o diagnóstico de TVP. Foram coletados dados demográficos e antecedentes familiares, assim como dados referentes à evolução clínica e terapêutica, tendo sido realizado também exame físico e ultrassonográfico dos membros envolvidos. Os grupos foram pareados quanto à idade e ao sexo, e as variáveis estudadas foram comparadas entre os grupos. Resultados: TVP foi mais frequente em mulheres. As trombofilias mais comumente encontradas foram a síndrome antifosfolípide e a mutação do fator V Leiden. Não houve diferença entre os grupos considerando-se o número de gestações e abortamentos, e a maioria das mulheres não engravidou após o episódio de TVP. A TVP não espontânea prevaleceu. A TVP proximal e em membro inferior esquerdo foi a mais frequente,...

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“…Spiezia investigated 530 patients with DVT for the principal thrombophilias (antithrombin, proteins C and S deficiencies, lupus anticoagulant, factor V Leiden, and prothrombin G20210A mutation) [33]. Overall, there was no association between presence of thrombophilia and risk of PTS (adjusted hazard ratio (HR) 1.23; 95% CI 0.92–1.64; P = 0.15).…”

Section: Studies In Dvt Patients (Table 1)mentioning

confidence: 99%

Association between Thrombophilia and the Post-Thrombotic Syndrome

Rabinovich

Kahn

2013

International Journal of Vascular Medicine

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The post thrombotic syndrome (PTS) is a chronic condition that develops in 20%–40% of deep vein thrombosis (DVT) patients. While risk factors that predispose to the development of venous thromboembolism (VTE) are widely known, factors that influence the development of PTS after DVT have not been well elucidated. Over 10% of the general population is affected by one or more identifiable inherited thrombophilias which have been shown to underlie at least 1/3 of cases of VTE. The various thrombophilias are important risk factors for VTE, but it is unknown whether they also increase the risk for development of PTS. We performed a review of studies that have reported on the association between thrombophilia and the development of PTS in populations of patients with DVT and with chronic venous ulcers. Studies vary with regards to the definition of PTS, study design, follow-up period, and present conflicting results. Based on these results, the question of whether thrombophilia predisposes to the development of PTS remains unanswered.

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Thrombophilia and the risk of post‐thrombotic syndrome: retrospective cohort observation

Cited by 18 publications

References 9 publications

Pathophysiology of Post-Thrombotic Syndrome: The Effect of Recurrent Venous Thrombosis and Inherited Thrombophilia

Pathophysiology of Post-Thrombotic Syndrome: The Effect of Recurrent Venous Thrombosis and Inherited Thrombophilia

Long-term clinical and ultrasonographic evaluation of thrombophilic patients with deep venous thrombosis

Association between Thrombophilia and the Post-Thrombotic Syndrome

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